Varaico: Literature-Extracted Genetic Variants

Gene:FLT3
Variant:p.F594I
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FLT3

NM_004119.3:p.F594I

Associated Papers

A structure-based tool to interpret the significance of kinase mutations in clinical next generation sequencing in cancer.

Rangarajan A et al.

Frontiers in Oncology, 2025

Characterisation of FLT3 alterations in childhood acute lymphoblastic leukaemia.

Gutierrez-Camino A et al.

British Journal of Cancer, 2024

38049555 (PubMed )
Supplement: 41416_2023_2511_MOESM1_ESM.pdf

A new genomic framework to categorize pediatric acute myeloid leukemia.

Umeda M et al.

Nature Genetics, 2024

38212634 (PubMed )
Supplement: 41588_2023_1640_MOESM5_ESM.xlsx › Extended_data_Fig.1_source_data

Transcriptome-based molecular subtypes and differentiation hierarchies improve the classification framework of acute myeloid leukemia.

Cheng WY et al.

Proceedings of the National Academy of Sciences of the United States of America, 2022

36442087 (PubMed )
Supplement: pnas.2211429119.sd02.xlsx › snv_indel

Clinical and molecular features of FLT3 juxtamembrane domain missense mutations in acute myeloid leukaemia.

Jensen CE et al.

Journal of Cellular and Molecular Medicine, 2022

Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia.

Umeda M et al.

Blood Cancer Discovery, 2022

35176137 (PubMed )
Supplement: bcd-21-0160_supplemental_tables_supp1-32.xlsx › Table_S12_SNV_indel

Deletions in FLT-3 juxtamembrane domain define a new class of pathogenic mutations: case report and systematic analysis.

Young DJ et al.

Blood Advances, 2021

Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group.

Zhang J et al.

Blood, 2011

A novel point mutation within the juxtamembrane domain of the flt3 gene in acute myeloid leukemia.

Gianfelici V et al.

Annals of Hematology, 2011

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."