Varaico: Literature-Extracted Genetic Variants

Gene:FLT3
Variant:p.L576Q
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FLT3

NM_004119.3:p.L576Q

Associated Papers

Persistent postremission clonal hematopoiesis shapes the relapse trajectories of acute myeloid leukemia.

Chow RD et al.

Blood Advances, 2025

39938015 (PubMed )
Supplement: BLOODA_ADV-2024-015149-mmc2.xlsx › S2

Early drivers of clonal hematopoiesis shape the evolutionary trajectories of de novo acute myeloid leukemia.

Chow RD et al.

Medrxiv : the Preprint Server for Health Sciences, 2024

39252918 (PubMed )
Supplement: media-1.xlsx › S1

Non-canonical FLT3 alterations reveal novel germline FLT3 variants leading to somatic gene rescue mutations.

Gordon J et al.

Blood Cancer Journal, 2024

Characterisation of FLT3 alterations in childhood acute lymphoblastic leukaemia.

Gutierrez-Camino A et al.

British Journal of Cancer, 2024

38049555 (PubMed )
Supplement: 41416_2023_2511_MOESM1_ESM.pdf

Clinical and molecular features of FLT3 juxtamembrane domain missense mutations in acute myeloid leukaemia.

Jensen CE et al.

Journal of Cellular and Molecular Medicine, 2022

Pathophysiologic and clinical implications of molecular profiles resultant from deletion 5q.

Adema V et al.

Ebiomedicine, 2022

35617825 (PubMed )
Supplement: mmc3.xlsx › Suppl_Table_3

Point Mutations in the FLT3-ITD Region Are Rare but Recurrent Alterations in Adult AML and Associated With Concomitant KMT2A-PTD.

Stasik S et al.

Frontiers in Oncology, 2022

The mutational spectrum of FLT3 gene in acute lymphoblastic leukemia is different from acute myeloid leukemia.

Zhang Y et al.

Cancer Gene Therapy, 2020

Invariant patterns of clonal succession determine specific clinical features of myelodysplastic syndromes.

Nagata Y et al.

Nature Communications, 2019

31772163 (PubMed )
Supplement: 41467_2019_13001_MOESM4_ESM.xlsx › SuppData2_AllVariantswithClone

Use of Sorafenib as an effective treatment in an AML patient carrying a new point mutation affecting the Juxtamembrane domain of FLT3.

Martínez-López J et al.

British Journal of Haematology, 2012

[Detection of point mutation at second tyrosine kinase domain of FLT3 gene in acute myeloid leukemia].

Wang LH et al.

Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi, 2005

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."