Varaico: Literature-Extracted Genetic Variants

Gene:FOXA1
Variant:p.M253K
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FOXA1

NM_004496.5:p.M253K

Associated Papers

FOXA1 mutations co-opt nascent transcription factor networks in partnership with androgen receptor to enhance prostate tumorigenicity.

Ladewig EM et al.

Cell Reports, 2026

Clinically-observed FOXA1 mutations upregulate SEMA3C through transcriptional derepression in prostate cancer.

Tam KJ et al.

Scientific Reports, 2024

Prospective clinical sequencing of 1016 Chinese prostate cancer patients: uncovering genomic characterization and race disparity.

Wei Y et al.

Molecular Oncology, 2023

37584393 (PubMed )
Supplement: MOL2-17-2183-s002.xlsx › Table_S14

Standing in the canine precision medicine knowledge gap: Improving annotation of canine cancer genomic biomarkers through systematic comparative analysis of human cancer mutations in COSMIC.

Sakthikumar S et al.

Veterinary and Comparative Oncology, 2023

37248814 (PubMed )
Supplement: supplement_1.xlsx › Supp._Table_5

Detection of disease-causing mutations in prostate cancer by NGS sequencing.

Mangolini A et al.

Cell Biology International, 2022

FOXA1 Mutations Reveal Distinct Chromatin Profiles and Influence Therapeutic Response in Breast Cancer.

Arruabarrena-Aristorena A et al.

Cancer Cell, 2020

A genomic and epigenomic atlas of prostate cancer in Asian populations.

Li J et al.

Nature, 2020

Forkhead domain mutations in FOXA1 drive prostate cancer progression.

Gao S et al.

Cell Research, 2019

Altered chromatin recruitment by FOXA1 mutations promotes androgen independence and prostate cancer progression.

Xu B et al.

Cell Research, 2019

FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes.

Adams EJ et al.

Nature, 2019

Genetic Progression of High Grade Prostatic Intraepithelial Neoplasia to Prostate Cancer.

Jung SH et al.

European Urology, 2016

The Molecular Taxonomy of Primary Prostate Cancer.

Unknown Author

Cell, 2015

FOXA1 mutations in hormone-dependent cancers.

Robinson JL et al.

Frontiers in Oncology, 2013

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."