Varaico: Literature-Extracted Genetic Variants

Gene:FOXA1
Variant:p.R219S
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FOXA1

NM_004496.5:p.R219S

Associated Papers

Blood-Based Genomic Alteration Signature for Predicting Progression-Free Survival in De Novo Metastatic Hormone-Sensitive Prostate Cancer: A Real-World Study.

Wang R et al.

Cancer Research Communications, 2025

41217768 (PubMed )
Supplement: crc-25-0384_supplementary_table_s2_suppst2.xlsx › Supplementary_Table_2

Comprehensive genomic landscape of metastatic hormone-sensitive prostate cancer in the Chinese population.

Yang B et al.

World Journal of Surgical Oncology, 2025

41121095 (PubMed )
Supplement: 12957_2025_4049_MOESM3_ESM.xlsx › Somatic_mutations

Deep Sequencing Reveals Novel Mutations in Androgen Receptor-Related Genes in Prostate Cancer.

Pedroza-Torres A et al.

International Journal of Molecular Sciences, 2025

Structurally Oriented Classification of FOXA1 Alterations Identifies Prostate Cancers with Opposing Clinical Outcomes and Distinct Molecular and Immunologic Subtypes.

Hwang J et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2025

Rarγ-Foxa1 signaling promotes luminal identity in prostate progenitors and is disrupted in prostate cancer.

De Felice D et al.

Embo Reports, 2025

Clinically-observed FOXA1 mutations upregulate SEMA3C through transcriptional derepression in prostate cancer.

Tam KJ et al.

Scientific Reports, 2024

Rarγ -Foxa1 signaling promotes luminal identity in prostate progenitors and is disrupted in prostate cancer.

Felice D et al.

Biorxiv : the Preprint Server for Biology, 2024

Prospective clinical sequencing of 1016 Chinese prostate cancer patients: uncovering genomic characterization and race disparity.

Wei Y et al.

Molecular Oncology, 2023

37584393 (PubMed )
Supplement: MOL2-17-2183-s002.xlsx › Table_S14

Standing in the canine precision medicine knowledge gap: Improving annotation of canine cancer genomic biomarkers through systematic comparative analysis of human cancer mutations in COSMIC.

Sakthikumar S et al.

Veterinary and Comparative Oncology, 2023

37248814 (PubMed )
Supplement: supplement_1.xlsx › Supp._Table_5

CancerVar: An artificial intelligence-empowered platform for clinical interpretation of somatic mutations in cancer.

Li Q et al.

Science Advances, 2022

Anticancer drug resistance: An update and perspective.

Nussinov R et al.

Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy, 2021

Development, maturation, and maintenance of human prostate inferred from somatic mutations.

Grossmann S et al.

Cell Stem Cell, 2021

FOXA1 mutations influence the therapeutic response of breast cancer by altering chromatin state.

Arruabarrena-Aristorena A et al.

Molecular & Cellular Oncology, 2021

A genomic and epigenomic atlas of prostate cancer in Asian populations.

Li J et al.

Nature, 2020

FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes.

Adams EJ et al.

Nature, 2019

Biallelic tumour suppressor loss and DNA repair defects in de novo small-cell prostate carcinoma.

Chedgy EC et al.

The Journal of Pathology, 2018

Genetic Progression of High Grade Prostatic Intraepithelial Neoplasia to Prostate Cancer.

Jung SH et al.

European Urology, 2016

Characterization of the genomic architecture and mutational spectrum of a small cell prostate carcinoma.

Scott AF et al.

Genes, 2014

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."