Varaico: Literature-Extracted Genetic Variants

Gene:FTO
Variant:p.A134T
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FTO

NM_001080432.3:p.A134T

Associated Papers

Translating IBD Genomics into Clinical Practice.

Singh P et al.

Digestive Diseases and Sciences, 2026

Evaluation of FTO polymorphism in 6-mercaptopurine related intolerance in children with acute lymphoblastic leukemia.

Singh M et al.

Cancer Chemotherapy and Pharmacology, 2023

Identification of genetic variants related to metabolic syndrome by next-generation sequencing.

Lee S et al.

Diabetology & Metabolic Syndrome, 2022

Analysis of coding variants in the human FTO gene from the gnomAD database.

Souza Junior MLF et al.

Plos One, 2022

Comprehensive mutations analyses of FTO (fat mass and obesity-associated gene) and their effects on FTO's substrate binding implicated in obesity.

Kumar R et al.

Frontiers in Nutrition, 2022

35923209 (PubMed )
Supplement: Data_Sheet_1.PDF

Comparison of potential inhibitors and targeting fat mass and obesity-associated protein causing diabesity through docking and molecular dynamics strategies.

Kumar SU et al.

Journal of Cellular Biochemistry, 2021

Variants of Lipid-Related Genes in Adult Japanese Patients with Severe Hypertriglyceridemia.

Matsunaga A et al.

Journal of Atherosclerosis and Thrombosis, 2020

An intronic FTO variant rs16952570 confers protection against thiopurine-induced myelotoxicities in multiethnic Asian IBD patients.

Chen S et al.

The Pharmacogenomics Journal, 2020

Genetic Studies of Inflammatory Bowel Disease-Focusing on Asian Patients.

Park SC et al.

Cells, 2019

NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study.

Kakuta Y et al.

Journal of Gastroenterology, 2018

29923122 (PubMed )
Supplement: 535_2018_1486_MOESM1_ESM.pdf

A coding variant in FTO confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD.

Kim HS et al.

Gut, 2017

Genome-Wide Association Studies of Chemotherapeutic Toxicities: Genomics of Inequality.

Mapes B et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2017

NUDT15, FTO, and RUNX1 genetic variants and thiopurine intolerance among Japanese patients with inflammatory bowel diseases.

Sato T et al.

Intestinal Research, 2017

Prevalence of loss-of-function FTO mutations in lean and obese individuals.

Meyre D et al.

Diabetes, 2010

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."