Varaico: Literature-Extracted Genetic Variants

Gene:FURIN
Variant:p.N440K
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FURIN

NM_002569.4:p.N440K

Associated Papers

Engineering a multivalent antibody nanoparticle to overcome SARS-CoV-2 Omicron immune evasion.

Sun H et al.

Plos Pathogens, 2025

Binding ability of Delta and Omicron towards the angiotensin-converting enzyme 2 receptor and antibodies: a computational study.

Nguyen QT et al.

Journal of Biomolecular Structure & Dynamics, 2025

Domain-Specific Impacts of Spike Protein Mutations on Infectivity and Antibody Escape in SARS-CoV-2 Omicron BA.1.

Kim TH et al.

Journal of Microbiology and Biotechnology, 2025

Characterizing HLA-A2-restricted CD8+ T-cell epitopes and immune responses to Omicron variants in SARS-CoV-2-inactivated vaccine recipients.

Xiao C et al.

Frontiers in Immunology, 2025

Ongoing evolution of SARS-CoV-2 drives escape from mRNA vaccine-induced humoral immunity.

Roederer AL et al.

Cell Reports. Medicine, 2024

39657661 (PubMed )
Supplement: mmc2.pdf

Genetic analysis of SARS-CoV-2 spike gene using Next Generation Sequencing from COVID-19 patients in Erbil/Iraq.

Ghareeb AA et al.

Cellular and Molecular Biology (noisy-le-grand, France), 2024

Molecular Insights into the Variability in Infection and Immune Evasion Capabilities of SARS-CoV-2 Variants: A Sequence and Structural Investigation of the RBD Domain.

Wang TH et al.

Journal of Chemical Information and Modeling, 2024

Complete genome sequencing of SARS-CoV-2 strains that were circulating in Uzbekistan over the course of four pandemic waves.

Esonova G et al.

Plos One, 2024

Dynamics of water-mediated interaction effects on the stability and transmission of Omicron.

Zaman N et al.

Scientific Reports, 2023

Omicron variant evolution on vaccines and monoclonal antibodies.

Sabbatucci M et al.

Inflammopharmacology, 2023

Potential use of high-resolution melting analyses for SARS-CoV-2 genomic surveillance.

de Souza Andrade A et al.

Journal of Virological Methods, 2023

Emergence of COVID-19 Variants: An Update.

Gupta P et al.

Cureus, 2023

Coarse-Grained Molecular Simulations and Ensemble-Based Mutational Profiling of Protein Stability in the Different Functional Forms of the SARS-CoV-2 Spike Trimers: Balancing Stability and Adaptability in BA.1, BA.2 and BA.2.75 Variants.

Verkhivker G et al.

International Journal of Molecular Sciences, 2023

A Detailed Overview of SARS-CoV-2 Omicron: Its Sub-Variants, Mutations and Pathophysiology, Clinical Characteristics, Immunological Landscape, Immune Escape, and Therapies.

Chatterjee S et al.

Viruses, 2023

Reversal of the unique Q493R mutation increases the affinity of Omicron S1-RBD for ACE2.

Philip AM et al.

Computational and Structural Biotechnology Journal, 2023

Genomic architecture and evolutionary relationship of BA.2.75: A Centaurus subvariant of Omicron SARS-CoV-2.

Basheer A et al.

Plos One, 2023

SARS-CoV-2 Omicron variants: burden of disease, impact on vaccine effectiveness and need for variant-adapted vaccines.

Pather S et al.

Frontiers in Immunology, 2023

The SARS-CoV-2 spike S375F mutation characterizes the Omicron BA.1 variant.

Kimura I et al.

Iscience, 2022

Epidemiology and Characteristics of SARS-CoV-2 Variants of Concern: The Impacts of the Spike Mutations.

Cocherie T et al.

Microorganisms, 2022

Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine.

Wu Y et al.

Cell Host & Microbe, 2022

Computational modeling of the effect of five mutations on the structure of the ACE2 receptor and their correlation with infectivity and virulence of some emerged variants of SARS-CoV-2 suggests mechanisms of binding affinity dysregulation.

Rodriguez JA et al.

Chemico-biological Interactions, 2022

Inferring selection effects in SARS-CoV-2 with Bayesian Viral Allele Selection.

Jankowiak M et al.

Plos Genetics, 2022

The Delta and Omicron Variants of SARS-CoV-2: What We Know So Far.

Chavda VP et al.

Vaccines, 2022

Variants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Vaccine Effectiveness.

Tulimilli SV et al.

Vaccines, 2022

A comparative study of spike protein of SARS-CoV-2 and its variant Omicron (B.1.1.529) on some immune characteristics.

Li X et al.

Scientific Reports, 2022

36224298 (PubMed )
Supplement: 41598_2022_21690_MOESM1_ESM.pdf

Omicron (BA.1) and sub-variants (BA.1.1, BA.2, and BA.3) of SARS-CoV-2 spike infectivity and pathogenicity: A comparative sequence and structural-based computational assessment.

Kumar S et al.

Journal of Medical Virology, 2022

Biophysical and Biochemical Characterization of the Receptor Binding Domain of SARS-CoV-2 Variants.

Khatri R et al.

The Protein Journal, 2022

Sensitivity to Vaccines, Therapeutic Antibodies, and Viral Entry Inhibitors and Advances To Counter the SARS-CoV-2 Omicron Variant.

Zhou H et al.

Clinical Microbiology Reviews, 2022

Determinants of Spike infectivity, processing, and neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2.

Pastorio C et al.

Cell Host & Microbe, 2022

35931073 (PubMed )
Supplement: mmc3.pdf

Evolution of the SARS-CoV-2 omicron variants BA.1 to BA.5: Implications for immune escape and transmission.

Shrestha LB et al.

Reviews in Medical Virology, 2022

Omicron Binding Mode: Contact Analysis and Dynamics of the Omicron Receptor-Binding Domain in Complex with ACE2.

Fazekas Z et al.

Journal of Chemical Information and Modeling, 2022

Omicron variant losing its critical mutations in the receptor-binding domain.

Desingu PA et al.

Journal of Medical Virology, 2022

Importation of SARS-CoV-2 Omicron variant in Beijing, China.

Li F et al.

Biosafety and Health, 2022

Structures of Omicron spike complexes and implications for neutralizing antibody development.

Guo H et al.

Cell Reports, 2022

Molecular Dynamics Studies on the Structural Stability Prediction of SARS-CoV-2 Variants Including Multiple Mutants.

Choi KE et al.

International Journal of Molecular Sciences, 2022

SARS-CoV-2 Omicron variant: recent progress and future perspectives.

Fan Y et al.

Signal Transduction and Targeted Therapy, 2022

Update on SARS-CoV-2 Omicron Variant of Concern and Its Peculiar Mutational Profile.

Alkhatib M et al.

Microbiology Spectrum, 2022

Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events.

Ou J et al.

Signal Transduction and Targeted Therapy, 2022

Characterization of the novel SARS-CoV-2 Omicron (B.1.1.529) variant of concern and its global perspective.

Saxena SK et al.

Journal of Medical Virology, 2022

Generalized Methodology for the Quick Prediction of Variant SARS-CoV-2 Spike Protein Binding Affinities with Human Angiotensin-Converting Enzyme II.

Williams AH et al.

The Journal of Physical Chemistry. B, 2022

Genomic characterization unravelling the causative role of SARS-CoV-2 Delta variant of lineage B.1.617.2 in 2nd wave of COVID-19 pandemic in Chhattisgarh, India.

Singh P et al.

Microbial Pathogenesis, 2022

Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement.

McCallum M et al.

Science (new York, N.y.), 2022

Variants of SARS CoV-2: mutations, transmissibility, virulence, drug resistance, and antibody/vaccine sensitivity.

Prüβ BM

Frontiers in Bioscience (landmark Edition), 2022

Role of COVID-19 Vaccines in SARS-CoV-2 Variants.

Zhou Z et al.

Frontiers in Immunology, 2022

Dynamics of Viral Infection and Evolution of SARS-CoV-2 Variants in the Calabria Area of Southern Italy.

De Marco C et al.

Frontiers in Microbiology, 2022

Insights on the mutational landscape of the SARS-CoV-2 Omicron variant.

Miller NL et al.

Biorxiv : the Preprint Server for Biology, 2021

Structure-Function Analyses of New SARS-CoV-2 Variants B.1.1.7, B.1.351 and B.1.1.28.1: Clinical, Diagnostic, Therapeutic and Public Health Implications.

Singh J et al.

Viruses, 2021

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."