Associated Papers
Breaking β-sheets in FUS prion-like domain preserves phase separation and function but prevents aggregation and toxicity.
Wake N et al.
Biorxiv : the Preprint Server for Biology, 2026
Targeting lipid droplets in FUS-linked amyotrophic lateral sclerosis mitigates neuronal and astrocytic lipotoxicity.
Marcadet L et al.
Brain : a Journal of Neurology, 2026
Small molecule JRMS modulating importin-β1 chaperone activity as a therapeutic strategy reducing TDP-43 pathology.
Shenouda M et al.
Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics, 2026
Targeted stress granule regulation by engineering a non-catalytic O-GlcNAc transferase.
Wang N et al.
Nature Communications, 2026
Somatic gene mutations in the motor cortex of patients with sporadic amyotrophic lateral sclerosis.
González-Velasco Ó et al.
Brain : a Journal of Neurology, 2025
In-Depth Study of Low-Complexity Domains: From Structural Diversity to Disease Mechanisms.
Xu H et al.
Cells, 2025
Histone Post-Translational Modifications and DNA Double-Strand Break Repair in Neurodegenerative Diseases: An Epigenetic Perspective.
Yeasmin A et al.
Biology, 2025
Is amyotrophic lateral sclerosis less severe in mice than in humans?
Dupuis L et al.
Current Opinion in Neurology, 2025
Genetic architecture of amyotrophic lateral sclerosis: a comprehensive review.
Yuan L et al.
Journal of Genetics and Genomics = Yi Chuan Xue Bao, 2025
Pathology of three ALS patients with FUS variants, including one likely benign Q23L variant lacking FUS inclusions.
Stenvall E et al.
Human Molecular Genetics, 2025
ATP as a Key Modulator of Fused-in-sarcoma Phase Separation and Aggregation: Insights into Amyotrophic Lateral Sclerosis Pathogenesis.
Kitamura K et al.
Journal of Molecular Biology, 2025
Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates.
Yan X et al.
Cell, 2025
Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALS.
Schweingruber C et al.
Nature Communications, 2025
Exploring Protein Misfolding in Amyotrophic Lateral Sclerosis: Structural and Functional Insights.
Ivantsik O et al.
Biomedicines, 2025
TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin.
Liang J et al.
Biorxiv : the Preprint Server for Biology, 2025
Modelling Population Genetic Screening in Rare Neurodegenerative Diseases.
Spargo TP et al.
Biomedicines, 2025
Graphene Quantum Dots Attenuate TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis.
Park NY et al.
Acs Nano, 2025
Amyotrophic lateral sclerosis caused by FUS mutations: advances with broad implications.
Moens TG et al.
The Lancet. Neurology, 2025
A systematic review and functional in-silico analysis of genes and variants associated with amyotrophic lateral sclerosis.
Arreola-Aldape CA et al.
Frontiers in Neuroscience, 2025
Case Report: A case of ALS type 6 associated with a FUS gene variant and right limb muscle weakness and atrophy as the initial symptom.
Zhan X et al.
Frontiers in Genetics, 2025
FUS-related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA damage response: a systematic review.
Almalki S et al.
Frontiers in Molecular Neuroscience, 2025
Oxidative stress-induced stress granules: a central link to protein aggregation in neurodegenerative diseases.
Younas N et al.
Frontiers in Neuroscience, 2025
Engineered NLS-chimera downregulates expression of aggregation-prone endogenous FUS.
Hayashi M et al.
Nature Communications, 2024
Targeted protein relocalization via protein transport coupling.
Ng CSC et al.
Nature, 2024
Glycolic acid and D-lactate-putative products of DJ-1-restore neurodegeneration in FUS - and SOD1-ALS.
Pal A et al.
Life Science Alliance, 2024
ALS Identified: two-year findings from a sponsored ALS genetic testing program.
Goutman SA et al.
Annals of Clinical and Translational Neurology, 2024
Mutation of the ALS-/FTD-Associated RNA-Binding Protein FUS Affects Axonal Development.
van Tartwijk FW et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2024
High-content analysis of proteostasis capacity in cellular models of amyotrophic lateral sclerosis (ALS).
Lambert-Smith IA et al.
Scientific Reports, 2024
Frontotemporal dementia-like disease progression elicited by seeded aggregation and spread of FUS.
Vazquez-Sanchez S et al.
Molecular Neurodegeneration, 2024
Frontotemporal dementia-like disease progression elicited by seeded aggregation and spread of FUS.
Vazquez-Sanchez S et al.
Biorxiv : the Preprint Server for Biology, 2024
An aberrant fused in sarcoma liquid droplet of amyotrophic lateral sclerosis pathological variant, R495X, accelerates liquid-solid phase transition.
Shiramasa Y et al.
Scientific Reports, 2024
The implications of physiological biomolecular condensates in amyotrophic lateral sclerosis.
Fakim H et al.
Seminars in Cell & Developmental Biology, 2024
FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease.
Kodavati M et al.
Nature Communications, 2024