Associated Papers
Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALS.
Schweingruber C et al.
Nature Communications, 2025
The nuclear envelope and nuclear pore complexes in neurodegenerative diseases.
Wu T et al.
Frontiers in Cell and Developmental Biology, 2025
Case Report: A case of ALS type 6 associated with a FUS gene variant and right limb muscle weakness and atrophy as the initial symptom.
Zhan X et al.
Frontiers in Genetics, 2025
Investigation of early axonal phenotypes in an iPSC-derived ALS cellular model using a microfluidic device.
Otomo A et al.
Frontiers in Cellular Neuroscience, 2025
FUS-related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA damage response: a systematic review.
Almalki S et al.
Frontiers in Molecular Neuroscience, 2025
Multiple lines of evidence for disruption of nuclear lamina and nucleoporins in FUS amyotrophic lateral sclerosis.
Okada K et al.
Brain : a Journal of Neurology, 2024
Mutation of the ALS-/FTD-Associated RNA-Binding Protein FUS Affects Axonal Development.
van Tartwijk FW et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2024
Modeling sporadic juvenile ALS in iPSC-derived motor neurons explores the pathogenesis of FUSR503fs mutation.
Chen L et al.
Frontiers in Cellular Neuroscience, 2024
Restoring Axonal Organelle Motility and Regeneration in Cultured FUS-ALS Motoneurons through Magnetic Field Stimulation Suggests an Alternative Therapeutic Approach.
Kandhavivorn W et al.
Cells, 2023
Rapid and Robust Multi-Phenotypic Assay System for ALS Using Human iPS Cells with Mutations in Causative Genes.
Kondo T et al.
International Journal of Molecular Sciences, 2023
Genetics of amyotrophic lateral sclerosis: seeking therapeutic targets in the era of gene therapy.
Suzuki N et al.
Journal of Human Genetics, 2023
Characterising the Genetic Landscape of Amyotrophic Lateral Sclerosis: A Catalogue and Assessment of Over 1,000 Published Genetic Variants.
McCann EP et al.
Journal of Neuromuscular Diseases, 2023
Phase separation and pathologic transitions of RNP condensates in neurons: implications for amyotrophic lateral sclerosis, frontotemporal dementia and other neurodegenerative disorders.
Naskar A et al.
Frontiers in Molecular Neuroscience, 2023
FUS mutations in Asian amyotrophic lateral sclerosis patients: a case report and literature review of genotype-phenotype correlations.
Lu T et al.
Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, 2022
DNA damage stress-induced translocation of mutant FUS proteins into cytosolic granules and screening for translocation inhibitors.
Nogami M et al.
Frontiers in Molecular Neuroscience, 2022
RNA Editing: A New Therapeutic Target in Amyotrophic Lateral Sclerosis and Other Neurological Diseases.
Hosaka T et al.
International Journal of Molecular Sciences, 2021
ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity.
Garone MG et al.
Communications Biology, 2021
Identification of hub molecules of FUS-ALS by Bayesian gene regulatory network analysis of iPSC model: iBRN.
Nogami M et al.
Neurobiology of Disease, 2021
Generation of six induced pluripotent stem cell lines from patients with amyotrophic lateral sclerosis with associated genetic mutations in either FUS or ANXA11.
Hedges EC et al.
Stem Cell Research, 2021
Genome Wide Analysis Points towards Subtype-Specific Diseases in Different Genetic Forms of Amyotrophic Lateral Sclerosis.
Dash BP et al.
International Journal of Molecular Sciences, 2020
The Occurrence of FUS Mutations in Pediatric Amyotrophic Lateral Sclerosis: A Case Report and Review of the Literature.
Picher-Martel V et al.
Journal of Child Neurology, 2020
Modeling ALS using iPSCs: is it possible to reproduce the phenotypic variations observed in patients in vitro?
Vasques JF et al.
Regenerative Medicine, 2020
Modeling cell-autonomous motor neuron phenotypes in ALS using iPSCs.
Hawrot J et al.
Neurobiology of Disease, 2020
A Human iPSC Line Carrying a de novo Pathogenic FUS Mutation Identified in a Patient With Juvenile ALS Differentiated Into Motor Neurons With Pathological Characteristics.
Chen L et al.
Frontiers in Cellular Neuroscience, 2020
Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons.
Akiyama T et al.
Ebiomedicine, 2019
Fused in Sarcoma: Properties, Self-Assembly and Correlation with Neurodegenerative Diseases.
Chen C et al.
Molecules (basel, Switzerland), 2019
Altered Tau Isoform Ratio Caused by Loss of FUS and SFPQ Function Leads to FTLD-like Phenotypes.
Ishigaki S et al.
Cell Reports, 2017
Current Advances and Limitations in Modeling ALS/FTD in a Dish Using Induced Pluripotent Stem Cells.
Guo W et al.
Frontiers in Neuroscience, 2017
Genotype-phenotype relationships in familial amyotrophic lateral sclerosis with FUS/TLS mutations in Japan.
Akiyama T et al.
Muscle & Nerve, 2016
Establishment of In Vitro FUS-Associated Familial Amyotrophic Lateral Sclerosis Model Using Human Induced Pluripotent Stem Cells.
Ichiyanagi N et al.
Stem Cell Reports, 2016
Next-generation sequencing of 28 ALS-related genes in a Japanese ALS cohort.
Nakamura R et al.
Neurobiology of Aging, 2016
Emerging mechanisms of molecular pathology in ALS.
Peters OM et al.
The Journal of Clinical Investigation, 2015
Extensive molecular genetic survey of Taiwanese patients with amyotrophic lateral sclerosis.
Soong BW et al.
Neurobiology of Aging, 2014
The role of FUS gene variants in neurodegenerative diseases.
Deng H et al.
Nature Reviews. Neurology, 2014
ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules.
Vance C et al.
Human Molecular Genetics, 2013
TARDBP and FUS mutations associated with amyotrophic lateral sclerosis: summary and update.
Lattante S et al.
Human Mutation, 2013
A hexanucleotide repeat expansion in C9ORF72 causes familial and sporadic ALS in Taiwan.
Tsai CP et al.
Neurobiology of Aging, 2012
FUS-related proteinopathies: lessons from animal models.
Lanson NA et al.
Brain Research, 2012
FUS, TARDBP, and SOD1 mutations in a Taiwanese cohort with familial ALS.
Tsai CP et al.
Neurobiology of Aging, 2011