Associated Papers
Autophagy induction mitigates FUS aggregate formation and early synaptic dysfunction at the NMJ in the FUS-ALS model.
Malik T et al.
Biorxiv : the Preprint Server for Biology, 2026
Axonal Eif5a hypusination controls local translation and mitigates defects in FUS-ALS.
Piol D et al.
Nature Neuroscience, 2026
Early Dropped Head Syndrome Is More Prevalent in C9orf72 and FUS/TLS ALS.
Gamez J et al.
Muscle & Nerve, 2025
Novel and rare variants in amyotrophic lateral sclerosis genes identified in Malaysian patients.
Zulhairy-Liong NA et al.
Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, 2025
Navigating the Autophagy Maze: ATG and Their Impact on Neurodegenerative Diseases.
Amirian R et al.
Molecular Neurobiology, 2025
Alternative splicing and the aging brain in AfrAbia: New frontiers in dementia research.
Aremu SA
Ibro Neuroscience Reports, 2025
CRISPR/Cas9 a genomic engineering technology for treatment in ALS mouse models.
Khan H et al.
Regenerative Therapy, 2025
Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity.
Resnick SJ et al.
Nature Communications, 2025
MARK2 regulates C9orf72 repeat-associated non-AUG translation.
Lu YN et al.
Proceedings of the National Academy of Sciences of the United States of America, 2025
Decoding Glycosylation in Neurodegenerative Diseases: Mechanistic Insights and Therapeutic Opportunities.
Yu H et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2025
Is amyotrophic lateral sclerosis less severe in mice than in humans?
Dupuis L et al.
Current Opinion in Neurology, 2025
Protein Structure-based FUS Mutational Subtypes Are Associated With Protein Mislocalization in Amyotrophic Lateral Sclerosis Patients.
Yang W et al.
Molecular Neurobiology, 2025
Genetic architecture of amyotrophic lateral sclerosis: a comprehensive review.
Yuan L et al.
Journal of Genetics and Genomics = Yi Chuan Xue Bao, 2025
MYC-driven gliosis impairs neuron-glia communication in amyotrophic lateral sclerosis.
Fioretti PV et al.
Brain : a Journal of Neurology, 2025
Activation of polo-like kinase 1 correlates with selective motor neuron vulnerability in familial ALS.
Szewczyk B et al.
Cell Reports, 2025
ALS-associated RNA-binding proteins promote UNC13A transcription through REST downregulation.
Watanabe Y et al.
The Embo Journal, 2025
Multifunctional regulation and treatment of ubiquitin specific protease 10.
Chen X et al.
Biochemical Pharmacology, 2025
Blueprint of Collapse: Precision Biomarkers, Molecular Cascades, and the Engineered Decline of Fast-Progressing ALS.
Șerban M et al.
International Journal of Molecular Sciences, 2025
Synaptic defects in adult drosophila motor neurons in a model of amyotrophic lateral sclerosis.
Malik T et al.
Human Molecular Genetics, 2025
Regulation of physiological and pathological condensates by molecular chaperones.
Akaree N et al.
The Febs Journal, 2025
β-propeller protein-associated neurodegeneration protein WDR45 regulates stress granule disassembly via phase separation with Caprin-1.
Li Y et al.
Nature Communications, 2025
DNA nanoflower Oligo-PROTAC for targeted degradation of FUS to treat neurodegenerative diseases.
Ge R et al.
Nature Communications, 2025
Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALS.
Schweingruber C et al.
Nature Communications, 2025
Exploring Protein Misfolding in Amyotrophic Lateral Sclerosis: Structural and Functional Insights.
Ivantsik O et al.
Biomedicines, 2025
Aggregates associated with amyotrophic lateral sclerosis sequester the actin-binding protein profilin 2.
Kubinski S et al.
Human Molecular Genetics, 2025
Targets and Gene Therapy of ALS (Part 1).
Shiryaeva O et al.
International Journal of Molecular Sciences, 2025
Modelling Population Genetic Screening in Rare Neurodegenerative Diseases.
Spargo TP et al.
Biomedicines, 2025
Advancements in genetic research and RNA therapy strategies for amyotrophic lateral sclerosis (ALS): current progress and future prospects.
Ruffo P et al.
Journal of Neurology, 2025
Amyotrophic lateral sclerosis caused by FUS mutations: advances with broad implications.
Moens TG et al.
The Lancet. Neurology, 2025
DNA Damage and Chromatin Rearrangement Work Together to Promote Neurodegeneration.
Sharma H et al.
Molecular Neurobiology, 2025
A systematic review and functional in-silico analysis of genes and variants associated with amyotrophic lateral sclerosis.
Arreola-Aldape CA et al.
Frontiers in Neuroscience, 2025
Case Report: A case of ALS type 6 associated with a FUS gene variant and right limb muscle weakness and atrophy as the initial symptom.
Zhan X et al.
Frontiers in Genetics, 2025
FUS-related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA damage response: a systematic review.
Almalki S et al.
Frontiers in Molecular Neuroscience, 2025
Oxidative stress-induced stress granules: a central link to protein aggregation in neurodegenerative diseases.
Younas N et al.
Frontiers in Neuroscience, 2025
Axonal transcriptome reveals upregulation of PLK1 as a protective mechanism in response to increased DNA damage in FUS P525L spinal motor neurons.
Zimyanin V et al.
Biorxiv : the Preprint Server for Biology, 2024
Multiple lines of evidence for disruption of nuclear lamina and nucleoporins in FUS amyotrophic lateral sclerosis.
Okada K et al.
Brain : a Journal of Neurology, 2024
Axonopathy Underlying Amyotrophic Lateral Sclerosis: Unraveling Complex Pathways and Therapeutic Insights.
Luan T et al.
Neuroscience Bulletin, 2024
Post-Translational Variants of Major Proteins in Amyotrophic Lateral Sclerosis Provide New Insights into the Pathophysiology of the Disease.
Bedja-Iacona L et al.
International Journal of Molecular Sciences, 2024
Glycolic acid and D-lactate-putative products of DJ-1-restore neurodegeneration in FUS - and SOD1-ALS.
Pal A et al.
Life Science Alliance, 2024
Clinical and genetic characteristics of 1672 cases of amyotrophic lateral sclerosis in China: a single-center retrospective study.
Shen D et al.
Journal of Neurology, 2024
ALS Identified: two-year findings from a sponsored ALS genetic testing program.
Goutman SA et al.
Annals of Clinical and Translational Neurology, 2024
Synaptopathy: presynaptic convergence in frontotemporal dementia and amyotrophic lateral sclerosis.
Clayton EL et al.
Brain : a Journal of Neurology, 2024
Mutation of the ALS-/FTD-Associated RNA-Binding Protein FUS Affects Axonal Development.
van Tartwijk FW et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2024
Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS.
Chatterjee M et al.
Nature Medicine, 2024