Associated Papers
Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALS.
Schweingruber C et al.
Nature Communications, 2025
Exploring Protein Misfolding in Amyotrophic Lateral Sclerosis: Structural and Functional Insights.
Ivantsik O et al.
Biomedicines, 2025
A systematic review and functional in-silico analysis of genes and variants associated with amyotrophic lateral sclerosis.
Arreola-Aldape CA et al.
Frontiers in Neuroscience, 2025
Multi-scale in silico analysis of the phase separation behavior of FUS mutants.
Fernando KS et al.
Journal of Materials Chemistry. B, 2024
Unraveling the molecular mechanisms of ALS: a network biology and structural modeling approach of investigating the impact of C9orf72 mutations.
Alzahrani AK et al.
Journal of Biomolecular Structure & Dynamics, 2024
FUS gene mutation in amyotrophic lateral sclerosis: a new case report and systematic review.
Xiao X et al.
Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, 2024
Characterising the Genetic Landscape of Amyotrophic Lateral Sclerosis: A Catalogue and Assessment of Over 1,000 Published Genetic Variants.
McCann EP et al.
Journal of Neuromuscular Diseases, 2023
Homozygous ALS-linked FUS P525L mutations cell- autonomously perturb transcriptome profile and chemoreceptor signaling in human iPSC microglia.
Kerk SY et al.
Stem Cell Reports, 2022
Investigating the Genetic Profile of the Amyotrophic Lateral Sclerosis/Frontotemporal Dementia (ALS-FTD) Continuum in Patients of Diverse Race, Ethnicity and Ancestry.
Mesaros M et al.
Genes, 2021
Insights into amyotrophic lateral sclerosis linked Pro525Arg mutation in the fused in sarcoma protein through in silico analysis and molecular dynamics simulation.
Chatterjee S et al.
Journal of Biomolecular Structure & Dynamics, 2021
Loss of the fragile X syndrome protein FMRP results in misregulation of nonsense-mediated mRNA decay.
Kurosaki T et al.
Nature Cell Biology, 2021
Contribution of Energy Dysfunction to Impaired Protein Translation in Neurodegenerative Diseases.
Liu YJ et al.
Frontiers in Cellular Neuroscience, 2021
A Deletion of the Nuclear Localization Signal Domain in the Fus Protein Induces Stable Post-stress Cytoplasmic Inclusions in SH-SY5Y Cells.
Notaro A et al.
Frontiers in Neuroscience, 2021
Lysine acetylation regulates the RNA binding, subcellular localization and inclusion formation of FUS.
Arenas A et al.
Human Molecular Genetics, 2020
FUS P525L mutation causing amyotrophic lateral sclerosis and movement disorders.
Zhou B et al.
Brain and Behavior, 2020
Aggressive FUS-Mutant Motor Neuron Disease Without Profound Spinal Cord Pathology.
Wongworawat YC et al.
Journal of Neuropathology and Experimental Neurology, 2020
Fused in Sarcoma: Properties, Self-Assembly and Correlation with Neurodegenerative Diseases.
Chen C et al.
Molecules (basel, Switzerland), 2019
Increased FUS levels in astrocytes leads to astrocyte and microglia activation and neuronal death.
Ajmone-Cat MA et al.
Scientific Reports, 2019
ALS mutations of FUS suppress protein translation and disrupt the regulation of nonsense-mediated decay.
Kamelgarn M et al.
Proceedings of the National Academy of Sciences of the United States of America, 2018
Clinical and experimental studies of a novel P525R FUS mutation in amyotrophic lateral sclerosis.
Kuang L et al.
Neurology. Genetics, 2017