Associated Papers
PML targets and resolves structured protein inclusions to mitigate neurodegeneration.
Wang Y et al.
Nature Cell Biology, 2026
Autophagy induction mitigates FUS aggregate formation and early synaptic dysfunction at the NMJ in the FUS-ALS model.
Malik T et al.
Biorxiv : the Preprint Server for Biology, 2026
Breaking β-sheets in FUS prion-like domain preserves phase separation and function but prevents aggregation and toxicity.
Wake N et al.
Biorxiv : the Preprint Server for Biology, 2026
Gene-targeted versus broad-spectrum therapies in ALS: comparative lessons and strategic outlook.
Shen Y et al.
Journal of Genetics and Genomics = Yi Chuan Xue Bao, 2026
Stress granules as a central hub linking organelle stress, aging, and neurodegeneration.
Ham HJ et al.
Bmb Reports, 2026
Compartment-specific transcriptome of motor neurons reveals impaired extracellular matrix signaling and activated cell cycle kinases in FUS-ALS.
Zimyanin V et al.
Neurobiology of Disease, 2026
Small molecule JRMS modulating importin-β1 chaperone activity as a therapeutic strategy reducing TDP-43 pathology.
Shenouda M et al.
Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics, 2026
Proteasome inhibition by VR23 enhances autophagic clearance of FUSP525L-mediated persistent stress granule in SH-SY5Y cells.
Kim SH et al.
Molecular Brain, 2026
Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains.
Guo L et al.
Molecular Cell, 2026
TDP-43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models.
Pir GJ et al.
The Febs Journal, 2026
Axonal Eif5a hypusination controls local translation and mitigates defects in FUS-ALS.
Piol D et al.
Nature Neuroscience, 2026
NEDD8, stress granules, and amyotrophic lateral sclerosis: unveiling the therapeutic potential of the NEDP1 protease.
Mitsiadou D et al.
Essays in Biochemistry, 2025
Revisiting oligodendrocytes in amyotrophic lateral sclerosis using human multicellular stem cell models.
Mouhi S et al.
Trends in Cell Biology, 2025
DNA damage response defects induced by the formation of TDP-43 and mutant FUS cytoplasmic inclusions and their pharmacological rescue.
Modafferi S et al.
Cell Death and Differentiation, 2025
Genetic spectrum among 2009 Iranian individuals with neuromuscular disorders using next generation sequencing and multiple ligation dependent probe amplification methods.
Molaei N et al.
Scientific Reports, 2025
In-Depth Study of Low-Complexity Domains: From Structural Diversity to Disease Mechanisms.
Xu H et al.
Cells, 2025
RNA G-Quadruplexes Function as a Tunable Switch of FUS Phase Separation.
Carey JL et al.
Biorxiv : the Preprint Server for Biology, 2025
Epitranscriptomic dysregulation in neurodegenerative diseases and its implications for disease pathology and mechanisms.
Shafik AM et al.
Neurochemistry International, 2025
C9orf72 ALS-causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules.
Bilican S et al.
Febs Letters, 2025
Dominant-negative isoform of TDP-43 is regulated by ALS-linked RNA-binding proteins.
Hasegawa-Ogawa M et al.
The Journal of Cell Biology, 2025
Is amyotrophic lateral sclerosis less severe in mice than in humans?
Dupuis L et al.
Current Opinion in Neurology, 2025
Antisense oligonucleotide therapy in amyotrophic lateral sclerosis.
Erdi-Krausz G et al.
Current Opinion in Neurology, 2025
Protein Structure-based FUS Mutational Subtypes Are Associated With Protein Mislocalization in Amyotrophic Lateral Sclerosis Patients.
Yang W et al.
Molecular Neurobiology, 2025
Genetic architecture of amyotrophic lateral sclerosis: a comprehensive review.
Yuan L et al.
Journal of Genetics and Genomics = Yi Chuan Xue Bao, 2025
Integrative Transcriptomic and Network-Based Analysis of Neuromuscular Diseases.
García-Criado F et al.
International Journal of Molecular Sciences, 2025
Activation of polo-like kinase 1 correlates with selective motor neuron vulnerability in familial ALS.
Szewczyk B et al.
Cell Reports, 2025
Using circular RNAs to target toxic RNA-binding proteins in amyotrophic lateral sclerosis.
Hollensen AK et al.
Molecular Therapy. Methods & Clinical Development, 2025
Transcriptomic Alteration in FUS-ALS Points Towards Apoptosis-Rather than Ferroptosis-Related Cell Death Pathway.
Dash BP et al.
Cells, 2025