Associated Papers
Functional validation of somatic variability in TP53 and KRAS for prediction of platinum sensitivity and prognosis in epithelial ovarian carcinoma patients.
Mohammad AOA et al.
Cancer Biology & Therapy, 2025
Respiration defects limit serine synthesis required for lung cancer growth and survival.
Cararo Lopes E et al.
Nature Communications, 2025
Denitrogenative Alkylation of K-Ras(G12D) Inhibits Oncogenic Signaling in Cancer Cells.
Zheng Q et al.
Journal of the American Chemical Society, 2025
Natural human tRNAAla anticodon variants mistranslate the genetic code.
Tennakoon R et al.
Rna (new York, N.y.), 2025
Novel druggable space in human KRAS G13D discovered using structural bioinformatics and a P-loop targeting monoclonal antibody.
Jungholm O et al.
Scientific Reports, 2024
Hedgehog ligand and receptor cooperatively regulate EGFR stability and activity in non-small cell lung cancer.
Huang A et al.
Cellular Oncology (dordrecht, Netherlands), 2024
RESPIRATION DEFECTS LIMIT SERINE SYNTHESIS REQUIRED FOR LUNG CANCER GROWTH AND SURVIVAL.
Lopes EC et al.
Biorxiv : the Preprint Server for Biology, 2024
Tumor cell-intrinsic SETD2 inactivation sensitizes cancer cells to immune checkpoint blockade through the NR2F1-STAT1 pathway.
Zheng X et al.
Journal for Immunotherapy of Cancer, 2023
Lasting response by vertical inhibition with cetuximab and trametinib in KRAS-mutated colorectal cancer patient-derived xenografts.
Reissig TM et al.
Molecular Oncology, 2023
Regulation of VKORC1L1 is critical for p53-mediated tumor suppression through vitamin K metabolism.
Yang X et al.
Cell Metabolism, 2023
Lymphatic disorders caused by mosaic, activating KRAS variants respond to MEK inhibition.
Sheppard SE et al.
Jci Insight, 2023
The RNA binding protein RALY suppresses p53 activity and promotes lung tumorigenesis.
Hu H et al.
Cell Reports, 2023
Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington's disease.
Mansky RH et al.
Cell Reports, 2023
Perseverance of protein homeostasis despite mistranslation of glycine codons with alanine.
Hasan F et al.
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 2023
MicroRNA-708 emerges as a potential candidate to target undruggable NRAS.
Pang JM et al.
Plos One, 2023
Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen.
Poole A et al.
Nature Communications, 2022
The Mettl3 epitranscriptomic writer amplifies p53 stress responses.
Raj N et al.
Molecular Cell, 2022
Depletion of transmembrane mucin 4 (Muc4) alters intestinal homeostasis in a genetically engineered mouse model of colorectal cancer.
Pothuraju R et al.
Aging, 2022
Genotype, Mortality, Morbidity, and Outcomes of 3β-Hydroxysteroid Dehydrogenase Deficiency in Algeria.
Ladjouze A et al.
Frontiers in Endocrinology, 2022
Formation and persistence of polyglutamine aggregates in mistranslating cells.
Lant JT et al.
Nucleic Acids Research, 2021
Ral GTPase-activating protein regulates the malignancy of pancreatic ductal adenocarcinoma.
Yoshimachi S et al.
Cancer Science, 2021
Apc-mutant cells act as supercompetitors in intestinal tumour initiation.
van Neerven SM et al.
Nature, 2021
Exosome-based Ldlr gene therapy for familial hypercholesterolemia in a mouse model.
Li Z et al.
Theranostics, 2021
Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program.
Bieging-Rolett KT et al.
Molecular Cell, 2020
p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis.
Olivero CE et al.
Molecular Cell, 2020
Differential O- and Glycosphingolipid Glycosylation in Human Pancreatic Adenocarcinoma Cells With Opposite Morphology and Metastatic Behavior.
Zhang T et al.
Frontiers in Oncology, 2020
Cooperative adaptation to therapy (CAT) confers resistance in heterogeneous non-small cell lung cancer.
Craig M et al.
Plos Computational Biology, 2019
Analyses on K-ras mutations and fascin expression in patients with cardia cancer.
Wei L et al.
Oncology Letters, 2019
Pten loss in Lgr5+ hair follicle stem cells promotes SCC development.
Chen H et al.
Theranostics, 2019
A Transcription Factor Addiction in Leukemia Imposed by the MLL Promoter Sequence.
Lu B et al.
Cancer Cell, 2018
Cigarette Smoke Induces Stem Cell Features of Pancreatic Cancer Cells via PAF1.
Nimmakayala RK et al.
Gastroenterology, 2018
Simultaneous identification of clinically relevant single nucleotide variants, copy number alterations and gene fusions in solid tumors by targeted next-generation sequencing.
Oliveira DM et al.
Oncotarget, 2018
Genetic deletion or small-molecule inhibition of the arginine methyltransferase PRMT5 exhibit anti-tumoral activity in mouse models of MLL-rearranged AML.
Kaushik S et al.
Leukemia, 2018
miR-124 Inhibits Lung Tumorigenesis Induced by K-ras Mutation and NNK.
Jin H et al.
Molecular Therapy. Nucleic Acids, 2017
[Prenatal diagnosis of Joubert syndrome:one case report and literature review].
Wen H et al.
Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences, 2017
Kras mutations increase telomerase activity and targeting telomerase is a promising therapeutic strategy for Kras-mutant NSCLC.
Liu W et al.
Oncotarget, 2017
STING expression and response to treatment with STING ligands in premalignant and malignant disease.
Baird JR et al.
Plos One, 2017
Nitrilase 1 modulates lung tumor progression in vitro and in vivo.
Wang YA et al.
Oncotarget, 2016
Smad4 loss promotes lung cancer formation but increases sensitivity to DNA topoisomerase inhibitors.
Haeger SM et al.
Oncogene, 2016
Development and validation of a whole-exome sequencing test for simultaneous detection of point mutations, indels and copy-number alterations for precision cancer care.
Rennert H et al.
Npj Genomic Medicine, 2016
Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.
Yun J et al.
Science (new York, N.y.), 2015
Murine pancreatic adenocarcinoma reduces Ikaros expression and disrupts T cell homeostasis.
Nelson N et al.
Plos One, 2015
[KRAS gene somatic mutations in Chilean patients with colorectal cancer].
Hurtado C et al.
Revista Medica De Chile, 2014
Deletion and down-regulation of SMAD4 gene in colorectal cancers in a Chinese population.
Ma Y et al.
Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu, 2014
The role of tumor suppressor menin in IL-6 regulation in mouse islet tumor cells.
Song TY et al.
Biochemical and Biophysical Research Communications, 2014
Epithelial stem cell mutations that promote squamous cell carcinoma metastasis.
White RA et al.
The Journal of Clinical Investigation, 2013
Molecular characterization of patient-derived human pancreatic tumor xenograft models for preclinical and translational development of cancer therapeutics.
Mattie M et al.
Neoplasia (new York, N.y.), 2013
Human mucin MUC1 RNA undergoes different types of alternative splicing resulting in multiple isoforms.
Zhang L et al.
Cancer Immunology, Immunotherapy : Cii, 2013