Associated Papers
p53 drives lung cancer regression through a TSC2/TFEB-dependent senescence program.
Wang M et al.
Cancer Discovery, 2025
Phosphorylation of cardiac sodium channel at Ser571 anticipates manifestations of the aging myopathy.
Pizzo E et al.
American Journal of Physiology. Heart and Circulatory Physiology, 2024
Cardiac-Specific Deletion of Scn8a Mitigates Dravet Syndrome-Associated Sudden Death in Adults.
King DR et al.
Jacc. Clinical Electrophysiology, 2024
Glioblastoma and its treatment are associated with extensive accelerated brain aging.
Ainslie AP et al.
Aging Cell, 2024
Palmitoylation-dependent regulation of cardiomyocyte Rac1 signaling activity and minor effects on cardiac hypertrophy.
Baldwin TA et al.
The Journal of Biological Chemistry, 2023
C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress.
Cicardi ME et al.
Iscience, 2023
STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease.
Hagemann TL et al.
Cells, 2023
C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress.
Cicardi ME et al.
Biorxiv : the Preprint Server for Biology, 2023
Rpl3l gene deletion in mice reduces heart weight over time.
Grimes KM et al.
Frontiers in Physiology, 2023
The Mettl3 epitranscriptomic writer amplifies p53 stress responses.
Raj N et al.
Molecular Cell, 2022
Chronically elevated branched chain amino acid levels are pro-arrhythmic.
Portero V et al.
Cardiovascular Research, 2022
The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma.
Bočkaj I et al.
Plos Genetics, 2021
Identification of distinct tumor cell populations and key genetic mechanisms through single cell sequencing in hepatoblastoma.
Bondoc A et al.
Communications Biology, 2021
Ca2+/calmodulin kinase II-dependent regulation of βIV-spectrin modulates cardiac fibroblast gene expression, proliferation, and contractility.
Nassal DM et al.
The Journal of Biological Chemistry, 2021
Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates.
García-Huerta P et al.
Acta Neuropathologica, 2020
Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility.
Yeshaw WM et al.
Elife, 2019
Phosphorylation of the ryanodine receptor 2 at serine 2030 is required for a complete β-adrenergic response.
Potenza DM et al.
The Journal of General Physiology, 2019
Impaired Nuclear Export of Polyglutamine-Expanded Androgen Receptor in Spinal and Bulbar Muscular Atrophy.
Arnold FJ et al.
Scientific Reports, 2019
Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability.
Schips TG et al.
Nature Communications, 2019
Identification of a Functional Non-coding Variant in the GABA A Receptor α2 Subunit of the C57BL/6J Mouse Reference Genome: Major Implications for Neuroscience Research.
Mulligan MK et al.
Frontiers in Genetics, 2019
Bioinformatic analysis of a plakophilin-2-dependent transcription network: implications for the mechanisms of arrhythmogenic right ventricular cardiomyopathy in humans and in boxer dogs.
Montnach J et al.
Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology, 2018
RBM20 Mutations Induce an Arrhythmogenic Dilated Cardiomyopathy Related to Disturbed Calcium Handling.
van den Hoogenhof MMG et al.
Circulation, 2018
Astrocytes expressing ALS-linked mutant FUS induce motor neuron death through release of tumor necrosis factor-alpha.
Kia A et al.
Glia, 2018
Genetic Reduction in Left Ventricular Protein Kinase C-α and Adverse Ventricular Remodeling in Human Subjects.
Hu R et al.
Circulation. Genomic and Precision Medicine, 2018
Linkage of Metabolic Defects to Activated PIK3CA Alleles in Endothelial Cells Derived from Lymphatic Malformation.
Glaser K et al.
Lymphatic Research and Biology, 2018
Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm.
Cerrone M et al.
Nature Communications, 2017
Glial fibrillary acidic protein exhibits altered turnover kinetics in a mouse model of Alexander disease.
Moody LR et al.
The Journal of Biological Chemistry, 2017
Two-Pore K+ Channel TREK-1 Regulates Sinoatrial Node Membrane Excitability.
Unudurthi SD et al.
Journal of the American Heart Association, 2016
Lithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease.
LaPash Daniels CM et al.
Plos One, 2015
Suppression of GFAP toxicity by alphaB-crystallin in mouse models of Alexander disease.
Hagemann TL et al.
Human Molecular Genetics, 2009