Associated Papers
Treatment of Congenital Hyperinsulinism With a Novel, Long-acting Glucagon Analogue.
Cannon M et al.
Jcem Case Reports, 2025
Clinical and Genetic Characteristics of Congenital Hyperinsulinism in Norway: A Nationwide Cohort Study.
Velde CD et al.
The Journal of Clinical Endocrinology and Metabolism, 2025
Glucokinase (GCK) in diabetes: from molecular mechanisms to disease pathogenesis.
Abu Aqel Y et al.
Cellular & Molecular Biology Letters, 2024
Comparison of Variants of Uncertain Significance in Three Regions of the Human Glucokinase Protein Using In Vitro and In Silico Analyses.
Gay C et al.
Cureus, 2024
Characterizing glucokinase variant mechanisms using a multiplexed abundance assay.
Gersing S et al.
Genome Biology, 2024
Glucokinase Variant Proteins Are Resistant to Fasting-Induced Uridine Diphosphate Glucose-Dependent Degradation in Maturity-Onset Diabetes of the Young Type 2 Patients.
Cho J et al.
International Journal of Molecular Sciences, 2023
Diffuse, Adult-Onset Nesidioblastosis/Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome (NIPHS): Review of the Literature of a Rare Cause of Hyperinsulinemic Hypoglycemia.
Dieterle MP et al.
Biomedicines, 2023
Characterizing glucokinase variant mechanisms using a multiplexed abundance assay.
Gersing S et al.
Biorxiv : the Preprint Server for Biology, 2023
A comprehensive map of human glucokinase variant activity.
Gersing S et al.
Genome Biology, 2023
REVEL Is Better at Predicting Pathogenicity of Loss-of-Function than Gain-of-Function Variants.
Hopkins JJ et al.
Human Mutation, 2023
Localized islet nuclear enlargement hyperinsulinism (LINE-HI) due to ABCC8 and GCK mosaic mutations.
Boodhansingh KE et al.
European Journal of Endocrinology, 2022
The novel GCK variant p.Val455Leu associated with hyperinsulinism is susceptible to allosteric activation and is conducive to weight gain and the development of diabetes.
Langer S et al.
Diabetologia, 2021
Hyperinsulinemic Hypoglycemia in Three Generations of a Family with Glucokinase Activating Mutation, c.295T>C (p.Trp99Arg).
Gilis-Januszewska A et al.
Genes, 2021
Clinical implications of the glucokinase impaired function - GCK MODY today.
Hulín J et al.
Physiological Research, 2020
L-Arginine prevents cereblon-mediated ubiquitination of glucokinase and stimulates glucose-6-phosphate production in pancreatic β-cells.
Cho J et al.
Communications Biology, 2020
Nanosecond-Timescale Dynamics and Conformational Heterogeneity in Human GCK Regulation and Disease.
Sternisha SM et al.
Biophysical Journal, 2020
Clinical and enzymatic phenotypes in congenital hyperinsulinemic hypoglycemia due to glucokinase-activating mutations: A report of two cases and a brief overview of the literature.
Ping F et al.
Journal of Diabetes Investigation, 2019
Nitric Oxide Activates β-Cell Glucokinase by Promoting Formation of the "Glucose-Activated" State.
Seckinger KM et al.
Biochemistry, 2018
Functional characterization of MODY2 mutations in the nuclear export signal of glucokinase.
Gutierrez-Nogués A et al.
Biochimica Et Biophysica Acta. Molecular Basis of Disease, 2018
Nutrient sensing in pancreatic islets: lessons from congenital hyperinsulinism and monogenic diabetes.
Lu M et al.
Annals of the New York Academy of Sciences, 2018
Octreotide therapy and restricted fetal growth: pregnancy in familial hyperinsulinemic hypoglycemia.
Geilswijk M et al.
Endocrinology, Diabetes & Metabolism Case Reports, 2017
[Actual trends in diagnostics and treatment of congenital hyperinsulinism].
Staník J et al.
Vnitrni Lekarstvi, 2016
Association of the glucokinase gene promoter polymorphism -30G > A (rs1799884) with gestational diabetes mellitus susceptibility: a case-control study and meta-analysis.
Han X et al.
Archives of Gynecology and Obstetrics, 2015
Molecular mechanisms of congenital hyperinsulinism.
Rahman SA et al.
Journal of Molecular Endocrinology, 2015
Glucokinase activity in the arcuate nucleus regulates glucose intake.
Hussain S et al.
The Journal of Clinical Investigation, 2015
Familial adult onset hyperinsulinism due to an activating glucokinase mutation: implications for pharmacological glucokinase activation.
Challis BG et al.
Clinical Endocrinology, 2014
Evaluation of a target region capture sequencing platform using monogenic diabetes as a study-model.
Gao R et al.
Bmc Genetics, 2014
Evolution- and structure-based computational strategy reveals the impact of deleterious missense mutations on MODY 2 (maturity-onset diabetes of the young, type 2).
George DC et al.
Theranostics, 2014
A report of 2 new cases of MODY2 and review of the literature: implications in the search for type 2 diabetes drugs.
Shammas C et al.
Metabolism: Clinical and Experimental, 2013
Conformational transition pathway in the activation process of allosteric glucokinase.
Huang M et al.
Plos One, 2013
Mutational analysis of allosteric activation and inhibition of glucokinase.
Zelent B et al.
The Biochemical Journal, 2011
Generation of N-ethyl-N-nitrosourea (ENU) diabetes models in mice demonstrates genotype-specific action of glucokinase activators.
Fenner D et al.
The Journal of Biological Chemistry, 2011
Crystal structure of E339K mutated human glucokinase reveals changes in the ATP binding site.
Liu Q et al.
Febs Letters, 2011
Liver Glucokinase(A456V) Induces Potent Hypoglycemia without Dyslipidemia through a Paradoxical Induction of the Catalytic Subunit of Glucose-6-Phosphatase.
Vidal-Alabró A et al.
International Journal of Endocrinology, 2011
Mutations in pancreatic ß-cell Glucokinase as a cause of hyperinsulinaemic hypoglycaemia and neonatal diabetes mellitus.
Hussain K
Reviews in Endocrine & Metabolic Disorders, 2010
Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia.
Osbak KK et al.
Human Mutation, 2009
23-Residue C-terminal alpha-helix governs kinetic cooperativity in monomeric human glucokinase.
Larion M et al.
Biochemistry, 2009
Extremes of clinical and enzymatic phenotypes in children with hyperinsulinism caused by glucokinase activating mutations.
Sayed S et al.
Diabetes, 2009
Biochemical characterization of MODY2 glucokinase variants V62M and G72R reveals reduced enzymatic activities relative to wild type.
Ralph EC et al.
Biochemistry, 2009
Activating mutations in the human glucokinase gene revealed by genetic selection.
Pal P et al.
Biochemistry, 2009
Activating glucokinase (GCK) mutations as a cause of medically responsive congenital hyperinsulinism: prevalence in children and characterisation of a novel GCK mutation.
Christesen HB et al.
European Journal of Endocrinology, 2008
Non-insulinoma persistent hyperinsulinaemic hypoglycaemia caused by an activating glucokinase mutation: hypoglycaemia unawareness and attacks.
Christesen HB et al.
Clinical Endocrinology, 2008