Associated Papers
A comprehensive map of human glucokinase variant activity.
Gersing S et al.
Genome Biology, 2023
37101203 (PubMed )
Supplement: 13059_2023_2935_MOESM2_ESM.xlsx › hyper-variants-positive-dddG
The novel GCK variant p.Val455Leu associated with hyperinsulinism is susceptible to allosteric activation and is conducive to weight gain and the development of diabetes.
Langer S et al.
Diabetologia, 2021
34532767 (PubMed )
Supplement: 125_2021_5553_MOESM1_ESM.pdf
Nanosecond-Timescale Dynamics and Conformational Heterogeneity in Human GCK Regulation and Disease.
Sternisha SM et al.
Biophysical Journal, 2020
23-Residue C-terminal alpha-helix governs kinetic cooperativity in monomeric human glucokinase.
Larion M et al.
Biochemistry, 2009
Activating mutations in the human glucokinase gene revealed by genetic selection.
Pal P et al.
Biochemistry, 2009
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