Associated Papers
The novel GCK variant p.Val455Leu associated with hyperinsulinism is susceptible to allosteric activation and is conducive to weight gain and the development of diabetes.
Langer S et al.
Diabetologia, 2021
34532767 (PubMed )
Supplement: 125_2021_5553_MOESM1_ESM.pdf
The second activating glucokinase mutation (A456V): implications for glucose homeostasis and diabetes therapy.
Christesen HB et al.
Diabetes, 2002
Study of the regulatory properties of glucokinase by site-directed mutagenesis: conversion of glucokinase to an enzyme with high affinity for glucose.
Moukil MA et al.
Diabetes, 2000
Select a paper to view details