Varaico: Literature-Extracted Genetic Variants

Gene:GCK
Variant:p.M224R
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GCK

NM_000162.5:p.M224R

Associated Papers

Evolution- and structure-based computational strategy reveals the impact of deleterious missense mutations on MODY 2 (maturity-onset diabetes of the young, type 2).

George DC et al.

Theranostics, 2014

24578721 (PubMed )
Supplement: thnov04p0366s1.pdf

Generation of N-ethyl-N-nitrosourea (ENU) diabetes models in mice demonstrates genotype-specific action of glucokinase activators.

Fenner D et al.

The Journal of Biological Chemistry, 2011

Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects.

Aigner B et al.

American Journal of Physiology. Endocrinology and Metabolism, 2008

Mutations in GCK and HNF-1alpha explain the majority of cases with clinical diagnosis of MODY in Spain.

Estalella I et al.

Clinical Endocrinology, 2007

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."