Associated Papers
Characterizing glucokinase variant mechanisms using a multiplexed abundance assay.
Gersing S et al.
Genome Biology, 2024
38627865 (PubMed )
Supplement: 13059_2024_3238_MOESM2_ESM.xlsx › ddG_1V4S_GLC
Genetic Variations in Hyperinsulinemic Hypoglycemia: Active versus Inactive Mutations.
Sabi SH et al.
Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy, 2024
Phenotypic Characterization of Congenital Hyperinsulinism Due to Novel Activating Glucokinase Mutations.
Li C et al.
Diabetes, 2023
Characterizing glucokinase variant mechanisms using a multiplexed abundance assay.
Gersing S et al.
Biorxiv : the Preprint Server for Biology, 2023
37292969 (PubMed )
Supplement: media-2.xlsx › ddG_all
Localized islet nuclear enlargement hyperinsulinism (LINE-HI) due to ABCC8 and GCK mosaic mutations.
Boodhansingh KE et al.
European Journal of Endocrinology, 2022
The novel GCK variant p.Val455Leu associated with hyperinsulinism is susceptible to allosteric activation and is conducive to weight gain and the development of diabetes.
Langer S et al.
Diabetologia, 2021
34532767 (PubMed )
Supplement: 125_2021_5553_MOESM1_ESM.pdf
A novel reverse two-hybrid method for the identification of missense mutations that disrupt protein-protein binding.
Vincent O et al.
Scientific Reports, 2020
Mechanistic Origins of Enzyme Activation in Human Glucokinase Variants Associated with Congenital Hyperinsulinism.
Sternisha SM et al.
Biochemistry, 2018
Role of connecting loop I in catalysis and allosteric regulation of human glucokinase.
Martinez JA et al.
Protein Science : a Publication of the Protein Society, 2014
Order-disorder transitions govern kinetic cooperativity and allostery of monomeric human glucokinase.
Larion M et al.
Plos Biology, 2012
Mutational analysis of allosteric activation and inhibition of glucokinase.
Zelent B et al.
The Biochemical Journal, 2011
Research and development of glucokinase activators for diabetes therapy: theoretical and practical aspects.
Matschinsky FM et al.
Handbook of Experimental Pharmacology, 2011
Activating mutations in the human glucokinase gene revealed by genetic selection.
Pal P et al.
Biochemistry, 2009
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