Varaico: Literature-Extracted Genetic Variants

Gene:GCLC
Variant:p.D43D
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GCLC

NM_001498.4:p.D43D

Associated Papers

A genetic variant of the glutamate-cysteine ligase catalytic subunit is associated with susceptibility to ischemic stroke in the Chinese population.

Liao T et al.

European Journal of Medical Research, 2025

Impact of Gene Modifiers on Cystic Fibrosis Phenotypic Profiles: A Systematic Review.

Ward A et al.

Human Mutation, 2024

Gene Polymorphism of Biotransformation Enzymes and Ciprofloxacin Pharmacokinetics in Pediatric Patients with Cystic Fibrosis.

Zyryanov SK et al.

Biomedicines, 2022

The Impact of Genetic Polymorphisms in Glutamate-Cysteine Ligase, a Key Enzyme of Glutathione Biosynthesis, on Ischemic Stroke Risk and Brain Infarct Size.

Polonikov A et al.

Life (basel, Switzerland), 2022

The role of polymorphisms in glutathione-related genes in asbestos-related diseases.

Franko A et al.

Radiology and Oncology, 2021

Genetic and epigenetic disease modifiers: non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD).

Choudhary NS et al.

Translational Gastroenterology and Hepatology, 2021

Allelic variations in genes belonging to glutathione system increase proliferative retinopathy risk in type 1 diabetes individuals.

Perez RV et al.

Gene, 2019

Disease-modifying genetic factors in cystic fibrosis.

Marson FAL

Current Opinion in Pulmonary Medicine, 2018

Genetic alterations in necrotizing enterocolitis.

Cuna A et al.

Seminars in Perinatology, 2017

Association of GCLM -588C/T and GCLC -129T/C Promoter Polymorphisms of Genes Coding the Subunits of Glutamate Cysteine Ligase with Ischemic Heart Disease Development in Kazakhstan Population.

Skvortsova L et al.

Disease Markers, 2017

Antioxidant-related gene polymorphisms associated with the cardio-ankle vascular index in young Russians.

Sorokin AV et al.

Cardiology in the Young, 2016

Necrotizing Enterocolitis Is Not Associated With Sequence Variants in Antioxidant Response Genes in Premature Infants.

Sampath V et al.

Journal of Pediatric Gastroenterology and Nutrition, 2016

Genetic polymorphisms and oxidative stress in non-alcoholic steatohepatitis (NASH): A mini review.

Oliveira CP et al.

Clinics and Research in Hepatology and Gastroenterology, 2015

Antioxidant response genes sequence variants and BPD susceptibility in VLBW infants.

Sampath V et al.

Pediatric Research, 2015

Plasma advanced oxidative protein products are associated with anti-oxidative stress pathway genes and malaria in a longitudinal cohort.

Zhang G et al.

Malaria Journal, 2014

Polymorphisms in the glutathione pathway modulate cystic fibrosis severity: a cross-sectional study.

Marson FA et al.

Bmc Medical Genetics, 2014

Genetic interaction of GSH metabolic pathway genes in cystic fibrosis.

de Lima Marson FA et al.

Bmc Medical Genetics, 2013

Association of genetic variants in the promoter region of genes encoding p22phox (CYBA) and glutamate cysteine ligase catalytic subunit (GCLC) and renal disease in patients with type 1 diabetes mellitus.

Vieira SM et al.

Bmc Medical Genetics, 2011

Association of polymorphisms in glutamate-cysteine ligase catalytic subunit and microsomal triglyceride transfer protein genes with nonalcoholic fatty liver disease.

Hashemi M et al.

Dna and Cell Biology, 2011

Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study.

Engström KS et al.

Environmental Health : a Global Access Science Source, 2011

Interaction of GAG trinucleotide repeat and C-129T polymorphisms impairs expression of the glutamate-cysteine ligase catalytic subunit gene.

Butticaz C et al.

Free Radical Biology & Medicine, 2011

[Somatic mutagenesis in human lymphocytes depending on genotypes for detoxification and oxidative response loci].

Sal'nikova LE et al.

Genetika, 2010

Genetic polymorphisms of Chinese patients with ischemic stroke and concurrent stenoses of extracranial and intracranial vessels.

Man BL et al.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, 2010

Association of polymorphisms of glutamate-cystein ligase and microsomal triglyceride transfer protein genes in non-alcoholic fatty liver disease.

Oliveira CP et al.

Journal of Gastroenterology and Hepatology, 2010

Functional significance of the GAG trinucleotide-repeat polymorphism in the gene for the catalytic subunit of gamma-glutamylcysteine ligase.

Nichenametla SN et al.

Free Radical Biology & Medicine, 2008

Genetic variation in glutathione-related genes and body burden of methylmercury.

Schläwicke Engström K et al.

Environmental Health Perspectives, 2008

Glutamate-cysteine ligase polymorphism, hypertension, and male sex are associated with cardiovascular events. Biochemical and genetic characterization of Italian subpopulation.

Campolo J et al.

American Heart Journal, 2007

[The glutamate-cysteine ligase catalytic subunit gene C-129T and modifier subunit gene G-23T polymorphisms and risk for coronary diseases].

Zuo HP et al.

Zhonghua Xin Xue Guan Bing Za Zhi, 2007

Polymorphisms and vascular cognitive impairment after ischemic stroke.

Baum L et al.

Journal of Geriatric Psychiatry and Neurology, 2007

Prediction of genetic risk for metabolic syndrome.

Yamada Y et al.

Atherosclerosis, 2007

Genetic analysis of CC16, OGG1 and GCLC polymorphisms and susceptibility to COPD.

Liu S et al.

Respirology (carlton, Vic.), 2007

Assessment of genetic factors for type 2 diabetes mellitus.

Yamada Y et al.

International Journal of Molecular Medicine, 2006

Chronic beryllium disease and glutathione biosynthesis genes.

Bekris LM et al.

Journal of Occupational and Environmental Medicine, 2006

Association of polymorphism in glutamate-cysteine ligase catalytic subunit gene with coronary vasomotor dysfunction and myocardial infarction.

Koide S et al.

Journal of the American College of Cardiology, 2003

[The relationship between genotypes and frequencies of chromosome aberrations in human lymphocytes under irradiation in vivo and in vitro].

Sal'nikova LE et al.

Radiatsionnaia Biologiia, Radioecologiia, 0

Association of polymorphisms of THBS2 and HSPA8 with hypertension in Japanese individuals with chronic kidney disease.

Oguri M et al.

Molecular Medicine Reports, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."