Varaico: Literature-Extracted Genetic Variants

Gene:GGCX
Variant:p.D547N
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GGCX

NM_000821.7:p.D547N

Associated Papers

Local Ancestry-Informed Candidate Pathway Analysis of Warfarin Stable Dose in Latino Populations.

Steiner HE et al.

Clinical Pharmacology and Therapeutics, 2023

Frequencies of VKORC1-1639G>A and rs397509427 in Patients on Warfarin and Healthy Syrian Subjects.

Altawil Y et al.

Cardiovascular Therapeutics, 2023

Impact of VKORC1, CYP2C9, CYP1A2, UGT1A1, and GGCX polymorphisms on warfarin maintenance dose: Exploring a new algorithm in South Chinese patients accept mechanical heart valve replacement.

Li J et al.

Medicine, 2022

The Impact of CYP2C9*11 Allelic Variant on the Pharmacokinetics of Phenytoin and (S)-Warfarin.

Wanounou M et al.

Clinical Pharmacology and Therapeutics, 2022

Effect of gene polymorphism on bleeding complications in Chinese Han patients taking warfarin.

Xia X et al.

European Journal of Clinical Pharmacology, 2022

The Role of GRP and MGP in the Development of Non-Hemorrhagic VKCFD1 Phenotypes.

Ghosh S et al.

International Journal of Molecular Sciences, 2022

To establish a model for the prediction of initial standard and maintenance doses of warfarin for the Han Chinese population based on gene polymorphism: a multicenter study.

Xia X et al.

European Journal of Clinical Pharmacology, 2022

Warfarin Pharmacogenomics for Precision Medicine in Real-Life Clinical Practice in Southern Africa: Harnessing 73 Variants in 29 Pharmacogenes.

Muyambo S et al.

Omics : a Journal of Integrative Biology, 2022

34958284 (PubMed )
Supplement: Supp_DataS1.docx

Ethnic Diversity and Warfarin Pharmacogenomics.

Asiimwe IG et al.

Frontiers in Pharmacology, 2022

35444556 (PubMed )
Supplement: Table1.DOCX

Profiling of warfarin pharmacokinetics-associated genetic variants: Black Africans portray unique genetic markers important for an African specific warfarin pharmacogenetics-dosing algorithm.

Ndadza A et al.

Journal of Thrombosis and Haemostasis : Jth, 2021

Influence of Renal Impairment and Genetic Subtypes on Warfarin Control in Japanese Patients.

Tanaka T et al.

Genes, 2021

A physiologically based pharmacokinetic/pharmacodynamic modeling approach for drug-drug interaction evaluation of warfarin enantiomers with sorafenib.

Wang Z et al.

Drug Metabolism and Pharmacokinetics, 2021

A network meta-analysis of CYP2C9, CYP2C9 with VKORC1 and CYP2C9 with VKORC1 and CYP4F2 genotype-based warfarin dosing strategies compared to traditional.

Sridharan K et al.

Journal of Clinical Pharmacy and Therapeutics, 2021

Value of VKORC1 (-1639G>A) rs9923231 genotyping in predicting warfarin dose: A replication study in South Indian population.

Harikrishnan S et al.

Indian Heart Journal, 2018

Bleeding predictors in patients following venous thromboembolism treated with vitamin K antagonists: Association with increased number of single nucleotide polymorphisms.

Bryk AH et al.

Vascular Pharmacology, 2018

Association between Vitamin K Epoxide Reductase (VKORC1) -1639G>A Polymorphism and Osteoporosis in Postmenopausal Women.

Kutluturk F et al.

Endocrine, Metabolic & Immune Disorders Drug Targets, 2018

The association between GGCX, miR-133 genetic polymorphisms and warfarin stable dosage in Han Chinese patients with mechanical heart valve replacement.

Tang XY et al.

Journal of Clinical Pharmacy and Therapeutics, 2017

Assessing the relative potency of (S)- and (R)-warfarin with a new PK-PD model, in relation to VKORC1 genotypes.

Ferrari M et al.

European Journal of Clinical Pharmacology, 2017

The VKORC1 polymorphism rs9923231 is associated with aneurysms of the ascending aorta in an Austrian population.

Andreas M et al.

Thrombosis Research, 2017

Impact of GGCX, STX1B and FPGS Polymorphisms on Warfarin Dose Requirements in European-Americans and Egyptians.

Hamadeh IS et al.

Clinical and Translational Science, 2016

VKORC1 and CYP2C9 genotype distribution in Asian countries.

Gaikwad T et al.

Thrombosis Research, 2014

Factors affecting warfarin dose requirements and quality of anticoagulation in adult Egyptian patients: role of gene polymorphism.

Bazan NS et al.

Irish Journal of Medical Science, 2014

Influence of VKORC1 gene polymorphisms on the effect of oral vitamin K supplementation in over-anticoagulated patients.

Zuchinali P et al.

Journal of Thrombosis and Thrombolysis, 2014

A pharmacogenetics-based warfarin maintenance dosing algorithm from Northern Chinese patients.

Chen J et al.

Plos One, 2014

Pharmacogenetics of warfarin: challenges and opportunities.

Lee MT et al.

Journal of Human Genetics, 2013

Genetic variation and haplotype structure of the gene Vitamin K epoxide reductase complex, subunit 1 in the Tamilian population.

Kumar DK et al.

Journal of Pharmacology & Pharmacotherapeutics, 2013

Novel associations of VKORC1 variants with higher acenocoumarol requirements.

Anton AI et al.

Plos One, 2013

Association of functional VKORC1 promoter polymorphism with occurrence and clinical aspects of ischemic stroke in a Greek population.

Ragia G et al.

Disease Markers, 2013

Clinical relevance of VKORC1 (G-1639A and C1173T) and CYP2C9*3 among patients on warfarin.

Teh LK et al.

Journal of Clinical Pharmacy and Therapeutics, 2012

The pharmacogenetics of the response to warfarin in Chinese.

Lam MP et al.

British Journal of Clinical Pharmacology, 2012

Association of the GGCX (CAA)16/17 repeat polymorphism with higher warfarin dose requirements in African Americans.

Cavallari LH et al.

Pharmacogenetics and Genomics, 2012

Therapeutic dosing of acenocoumarol: proposal of a population specific pharmacogenetic dosing algorithm and its validation in north Indians.

Rathore SS et al.

Plos One, 2012

[Distribution of variant alleles association with warfarin pharmacokinetics and pharmacodynamics in the Han population in China].

Liu Y et al.

Beijing Da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences, 2011

Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and VKORC1 genotypes and warfarin dosing.

Johnson JA et al.

Clinical Pharmacology and Therapeutics, 2011

Genetic factors associated with patient-specific warfarin dose in ethnic Indonesians.

Suriapranata IM et al.

Bmc Medical Genetics, 2011

[Possible application of pharmacogenomics to warfarin therapy].

Murata M

Rinsho Byori. the Japanese Journal of Clinical Pathology, 2011

Genetic warfarin dosing: tables versus algorithms.

Finkelman BS et al.

Journal of the American College of Cardiology, 2011

Gamma-glutamyl carboxylase and its influence on warfarin dose.

King CR et al.

Thrombosis and Haemostasis, 2010

New genetic variant that might improve warfarin dose prediction in African Americans.

Schelleman H et al.

British Journal of Clinical Pharmacology, 2010

Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups.

Limdi NA et al.

Blood, 2010

Impact of VKORC1 gene polymorphism on interindividual and interethnic warfarin dosage requirement--a systematic review and meta analysis.

Yang L et al.

Thrombosis Research, 2010

[Optimalisation of treatment with vitamin K antagonists--the role of gene polymorphisms].

Stępień E et al.

Kardiologia Polska, 2010

Influence of clinical and genetic factors on warfarin dose requirements among Japanese patients.

Ohno M et al.

European Journal of Clinical Pharmacology, 2009

CYP2C9*8 is prevalent among African-Americans: implications for pharmacogenetic dosing.

Scott SA et al.

Pharmacogenomics, 2009

A multiplex assay for detecting genetic variations in CYP2C9, VKORC1, and GGCX involved in warfarin metabolism.

Rai AJ et al.

Clinical Chemistry, 2009

Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin.

Gage BF et al.

Clinical Pharmacology and Therapeutics, 2008

Warfarin pharmacogenetics.

Limdi NA et al.

Pharmacotherapy, 2008

Pharmacogenetics of warfarin: current status and future challenges.

Wadelius M et al.

The Pharmacogenomics Journal, 2007

Genotypes of vitamin K epoxide reductase, gamma-glutamyl carboxylase, and cytochrome P450 2C9 as determinants of daily warfarin dose in Japanese patients.

Kimura R et al.

Thrombosis Research, 2007

Warfarin dose and the pharmacogenomics of CYP2C9 and VKORC1 - rationale and perspectives.

Yin T et al.

Thrombosis Research, 2007

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."