Associated Papers
The pharmacogenomic landscape in the Chinese: An analytics of pharmacogenetic variants in 206,640 individuals.
Wang LY et al.
Innovation (cambridge (mass.)), 2025
Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform.
Huang K et al.
Journal of Visualized Experiments : Jove, 2024
Genetic variations in methotrexate metabolic pathway genes influence methotrexate responses in rheumatoid arthritis patients in Malaysia.
Sha HX et al.
Scientific Reports, 2022
Impact of Variants in the ATIC and ARID5B Genes on Therapeutic Failure with Imatinib in Patients with Chronic Myeloid Leukemia.
Cereja Pantoja KBC et al.
Genes, 2022
Genetic variants associated with methotrexate-induced mucositis in cancer treatment: A systematic review and meta-analysis.
Maagdenberg H et al.
Critical Reviews in Oncology/hematology, 2021
Decoding variants in drug-metabolizing enzymes and transporters in solid tumor patients by whole-exome sequencing.
Aboul-Soud MAM et al.
Saudi Journal of Biological Sciences, 2021
Integrated Genomic, Functional, and Prognostic Characterization of Atypical Chronic Myeloid Leukemia.
Fontana D et al.
Hemasphere, 2020
Genetic and clinical prediction models for the efficacy and hepatotoxicity of methotrexate in patients with rheumatoid arthritis: a multicenter cohort study.
Onishi A et al.
The Pharmacogenomics Journal, 2020
Folyl polyglutamate synthethase (FPGS) gene polymorphisms may influence methotrexate adverse events in South Indian Tamil Rheumatoid Arthritis patients.
Muralidharan N et al.
The Pharmacogenomics Journal, 2020
Association of genes ARID5B, CEBPE and folate pathway with acute lymphoblastic leukemia in a population from the Brazilian Amazon region.
Carvalho DC et al.
Leukemia Research Reports, 2020
Are gene polymorphisms related to adverse events of methotrexate in patients with rheumatoid arthritis? A retrospective cohort study based on an updated meta-analysis.
Huang J et al.
Therapeutic Advances in Chronic Disease, 2020
Accumulation of rare coding variants in genes implicated in risk of human cleft lip with or without cleft palate.
Marini NJ et al.
American Journal of Medical Genetics. Part A, 2019
Targeted next generation sequencing as a tool for precision medicine.
Gulilat M et al.
Bmc Medical Genomics, 2019
Association of Cerebrospinal Fluid Biomarkers of Central Nervous System Injury With Neurocognitive and Brain Imaging Outcomes in Children Receiving Chemotherapy for Acute Lymphoblastic Leukemia.
Cheung YT et al.
Jama Oncology, 2018
Risk factors for abnormal hepatic enzyme elevation by methotrexate treatment in patients with rheumatoid arthritis: A hospital based-cohort study.
Hakamata J et al.
Modern Rheumatology, 2018
Factors Predicting the Therapeutic Response to Methotrexate in Japanese Patients with Rheumatoid Arthritis: A Hospital-Based Cohort Study.
Hakamata J et al.
Biological & Pharmaceutical Bulletin, 2018
Polymorphisms and Pharmacogenomics for the Clinical Efficacy of Methotrexate in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-analysis.
Qiu Q et al.
Scientific Reports, 2017
Folylpolyglutamate synthase is a major determinant of intracellular methotrexate polyglutamates in patients with rheumatoid arthritis.
Yamamoto T et al.
Scientific Reports, 2016
Genetic polymorphisms of enzyme proteins and transporters related to methotrexate response and pharmacokinetics in a Japanese population.
Hashiguchi M et al.
Journal of Pharmaceutical Health Care and Sciences, 2016
Gene polymorphisms in the folate metabolism and their association with MTX-related adverse events in the treatment of ALL.
Chen Y et al.
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine, 2015
Comparative pharmacogenetic analysis of risk polymorphisms in Caucasian and Vietnamese children with acute lymphoblastic leukemia: prediction of therapeutic outcome?
Hoang PT et al.
British Journal of Clinical Pharmacology, 2015
Pharmacogenetics of pemetrexed combination therapy in lung cancer: pathway analysis reveals novel toxicity associations.
Corrigan A et al.
The Pharmacogenomics Journal, 2014
Potentially functional SNPs (pfSNPs) as novel genomic predictors of 5-FU response in metastatic colorectal cancer patients.
Wang J et al.
Plos One, 2014
Association of the TYMS 3G/3G genotype with poor response and GGH 354GG genotype with the bone marrow toxicity of the methotrexate in RA patients.
Jekic B et al.
European Journal of Clinical Pharmacology, 2013
[Analysis of a 452C/T single nucleotide polymorphism in γ-glutamyl hydrolase gene in children with acute leukemia].
Zhang HH et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, 2012
Genetic polymorphism of γ-glutamyl hydrolase in Chinese acute leukemia children and identification of a novel double nonsynonymous mutation.
Chen X et al.
Pediatric Hematology and Oncology, 2012
Patterns of interaction between genetic and nongenetic attributes and methotrexate efficacy in rheumatoid arthritis.
Dervieux T et al.
Pharmacogenetics and Genomics, 2012
Genotyping of single nucleotide polymorphism in γ-glutamyl hydrolase gene by capillary electrophoresis.
Cheng HL et al.
Electrophoresis, 2011
Influence of polymorphisms within the methotrexate pathway genes on the toxicity and efficacy of methotrexate in patients with juvenile idiopathic arthritis.
Yanagimachi M et al.
British Journal of Clinical Pharmacology, 2011
Evaluation of 64 candidate single nucleotide polymorphisms as risk factors for neural tube defects in a large Irish study population.
Carter TC et al.
American Journal of Medical Genetics. Part A, 2011
Polymorphisms of the gamma-glutamyl hydrolase gene and risk of relapse to acute lymphoblastic leukemia in Mexico.
Organista-Nava J et al.
Leukemia Research, 2010
Gene-gene interactions in folate and adenosine biosynthesis pathways affect methotrexate efficacy and tolerability in rheumatoid arthritis.
Dervieux T et al.
Pharmacogenetics and Genomics, 2009
Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review.
Carr DF et al.
The Pharmacogenomics Journal, 2009
Genetic polymorphisms in folate pathway enzymes as a possible marker for predicting the outcome of methotrexate therapy in Japanese patients with rheumatoid arthritis.
Hayashi H et al.
Journal of Clinical Pharmacy and Therapeutics, 2009
Metaanalysis of methylenetetrahydrofolate reductase (MTHFR) polymorphisms affecting methotrexate toxicity.
Fisher MC et al.
The Journal of Rheumatology, 2009
Genetic polymorphism of C452T (T127I) in human gamma-glutamyl hydrolase in a Japanese population.
Hayashi H et al.
Biological & Pharmaceutical Bulletin, 2007
Epigenetic regulation of human gamma-glutamyl hydrolase activity in acute lymphoblastic leukemia cells.
Cheng Q et al.
American Journal of Human Genetics, 2006
The pharmacogenetics of methotrexate in inflammatory bowel disease.
Herrlinger KR et al.
Pharmacogenetics and Genomics, 2005
A substrate specific functional polymorphism of human gamma-glutamyl hydrolase alters catalytic activity and methotrexate polyglutamate accumulation in acute lymphoblastic leukaemia cells.
Cheng Q et al.
Pharmacogenetics, 2004
Identification of single nucleotide polymorphisms in the human gamma-glutamyl hydrolase gene and characterization of promoter polymorphisms.
Chave KJ et al.
Gene, 2003