Varaico: Literature-Extracted Genetic Variants

Gene:GHRL
Variant:p.Q90L
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GHRL

NM_016362.5:p.Q90L

Associated Papers

Variants in GHRL, RETN, and PLIN1 are associated with obesity, diabetes, and metabolic syndrome, and influence food consumption in adults with obesity.

Dos Santos MA et al.

Nutrition Research (new York, N.y.), 2025

SNPs-Panel Polymorphism Variations in GHRL and GHSR Genes Are Not Associated with Prostate Cancer.

Merabet N et al.

Biomedicines, 2023

Rare Variants of Obesity-Associated Genes in Young Adults with Abdominal Obesity.

Bairqdar A et al.

Journal of Personalized Medicine, 2023

Functionally Significant Variants in Genes Associated with Abdominal Obesity: A Review.

Bairqdar A et al.

Journal of Personalized Medicine, 2023

Decoding the genetic relationship between Alzheimer's disease and type 2 diabetes: potential risk variants and future direction for North Africa.

Boukhalfa W et al.

Frontiers in Aging Neuroscience, 2023

37342358 (PubMed )
Supplement: Table_2.XLSX › Table_2_SNPnexus_annotation

A Metabolic Perspective on Reward Abnormalities in Anorexia Nervosa.

Duriez P et al.

Trends in Endocrinology and Metabolism: Tem, 2019

Ghrelin and aggressive behaviours-Evidence from preclinical and human genetic studies.

Vestlund J et al.

Psychoneuroendocrinology, 2019

GHRL Gene Leu72Met Polymorphism and Type 2 Diabetes Mellitus: A Meta-Analysis Involving 8,194 Participants.

Li YY et al.

Frontiers in Endocrinology, 2019

Ethnicity-Specific Association Between Ghrelin Leu72Met Polymorphism and Type 2 Diabetes Mellitus Susceptibility: An Updated Meta-Analysis.

Huang R et al.

Frontiers in Genetics, 2018

Association of plasma ghrelin levels and ghrelin rs4684677 polymorphism with mild cognitive impairment in type 2 diabetic patients.

Huang R et al.

Oncotarget, 2017

Genetic variation of the growth hormone secretagogue receptor gene is associated with alcohol use disorders identification test scores and smoking.

Suchankova P et al.

Addiction Biology, 2016

Leu72Met408 Polymorphism of the Ghrelin Gene Is Associated With Early Phase of Gastric Emptying in the Patients With Functional Dyspepsia in Japan.

Yamawaki H et al.

Journal of Neurogastroenterology and Motility, 2015

The association between rs4684677 T/A polymorphism in preproghrelin gene and predisposition to autoimmune thyroid diseases in children.

Moniuszko A et al.

Autoimmunity, 2015

Ghrelin Gene Variants Influence on Metabolic Syndrome Components in Aged Spanish Population.

Mora M et al.

Plos One, 2015

Associations between ghrelin and ghrelin receptor polymorphisms and cancer in Caucasian populations: a meta-analysis.

Pabalan NA et al.

Bmc Genetics, 2014

Polymorphisms for ghrelin with consequences on satiety and metabolic alterations.

Perret J et al.

Current Opinion in Clinical Nutrition and Metabolic Care, 2014

Preproghrelin polymorphism Q90L (rs4684677) in gestational diabetes.

Rocha RA et al.

Arquivos Brasileiros De Endocrinologia E Metabologia, 2014

A possible association between panic disorder and a polymorphism in the preproghrelingene.

Hansson C et al.

Psychiatry Research, 2013

The preproghrelin 3056 TT genotype is associated with the feeling of hunger and low acylated ghrelin levels in Japanese patients with Helicobacter pylori-negative functional dyspepsia.

Futagami S et al.

Internal Medicine (tokyo, Japan), 2013

A natural variant of obestatin, Q90L, inhibits ghrelin's action on food intake and GH secretion and targets NPY and GHRH neurons in mice.

Hassouna R et al.

Plos One, 2012

Genetic variants of ghrelin in metabolic disorders.

Ukkola O

Peptides, 2011

Ghrelin gene polymorphisms in rheumatoid arthritis.

Ozgen M et al.

Joint Bone Spine, 2011

No association of the neuropeptide Y (Leu7Pro) and ghrelin gene (Arg51Gln, Leu72Met, Gln90Leu) single nucleotide polymorphisms with eating disorders.

Kindler J et al.

Nordic Journal of Psychiatry, 2011

The association of ghrelin polymorphisms with coronary artery disease and ischemic chronic heart failure in an elderly Chinese population.

Zhang Q et al.

Clinical Biochemistry, 2011

Plasma ghrelin levels and polymorphisms of ghrelin gene in Chinese obese children and adolescents.

Zhu JF et al.

Irish Journal of Medical Science, 2010

Influence of ghrelin gene polymorphisms on hypertension and atherosclerotic disease.

Berthold HK et al.

Hypertension Research : Official Journal of the Japanese Society of Hypertension, 2010

The role of ghrelin and ghrelin-receptor gene variants and promoter activity in type 2 diabetes.

Garcia EA et al.

European Journal of Endocrinology, 2009

Association between the obestatin and BDNF gene polymorphism and panic disorder, and depressive disorder.

Ishii T et al.

Psychiatric Genetics, 2009

Plasma obestatin, ghrelin, and ghrelin/obestatin ratio are increased in underweight patients with anorexia nervosa but not in symptomatic patients with bulimia nervosa.

Monteleone P et al.

The Journal of Clinical Endocrinology and Metabolism, 2008

Polymorphisms of the ghrelin/obestatin gene and ghrelin levels in Chinese children with short stature.

Zou CC et al.

Clinical Endocrinology, 2008

Polymorphisms of genes coding for ghrelin and its receptor in relation to anthropometry, circulating levels of IGF-I and IGFBP-3, and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC).

Dossus L et al.

Carcinogenesis, 2008

A new variation in the promoter region, the -604 C>T, and the Leu72Met polymorphism of the ghrelin gene are associated with protection to insulin resistance.

Zavarella S et al.

International Journal of Obesity (2005), 2008

Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome: The Finnish Diabetes Prevention Study.

Kilpeläinen TO et al.

Metabolism: Clinical and Experimental, 2008

Genotype-phenotype associations in obesity dependent on definition of the obesity phenotype.

Kring SI et al.

Obesity Facts, 2008

Examining the candidacy of ghrelin as a gene responsible for variation in adult stature in a United Kingdom population with type 2 diabetes.

Gueorguiev M et al.

The Journal of Clinical Endocrinology and Metabolism, 2007

Family trios analysis of common polymorphisms in the obestatin/ghrelin, BDNF and AGRP genes in patients with Anorexia nervosa: association with subtype, body-mass index, severity and age of onset.

Dardennes RM et al.

Psychoneuroendocrinology, 2007

Variants within the ghrelin gene--association with HDL-cholesterol, but not with body mass index.

Hubácek JA et al.

Folia Biologica, 2007

Association between ghrelin gene variations and blood pressure in subjects with impaired glucose tolerance.

Mager U et al.

American Journal of Hypertension, 2006

Ghrelin: a hormone regulating food intake and energy homeostasis.

Gil-Campos M et al.

The British Journal of Nutrition, 2006

Case-control and combined family trios analysis of three polymorphisms in the ghrelin gene in European patients with anorexia and bulimia nervosa.

Cellini E et al.

Psychiatric Genetics, 2006

Variants in the ghrelin gene are associated with metabolic syndrome in the Old Order Amish.

Steinle NI et al.

The Journal of Clinical Endocrinology and Metabolism, 2005

Mutation analysis of the preproghrelin gene: no association with obesity and type 2 diabetes.

Larsen LH et al.

Clinical Biochemistry, 2005

Ghrelin gene polymorphisms and ghrelin, insulin, IGF-I, leptin and anthropometric data in children and adolescents.

Vivenza D et al.

European Journal of Endocrinology, 2004

Genetics and Epigenetics of Eating Disorders.

Yilmaz Z et al.

Advances in Genomics and Genetics, 0

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