Varaico: Literature-Extracted Genetic Variants

Gene:GHRL
Variant:p.L72M
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GHRL

NM_016362.5:p.L72M

Associated Papers

Role of rs490683 variant in the promoter region of the ghrelin receptor gene on body weight and metabolic syndrome after a partial meal replacement hypocaloric diet.

de Luis D et al.

Journal of Diabetes and Its Complications, 2025

Variants of Visceral Adipocytokine Genes in Obesity and Coronary Atherosclerosis: A Review.

Vitalievna GE et al.

Current Medicinal Chemistry, 2025

Clinical-exome sequencing unveils the genetic landscape of polycystic ovarian syndrome (PCOS) focusing on lean and obese phenotypes: implications for cost-effective diagnosis and personalized treatment.

Dhar S et al.

Scientific Reports, 2024

Genetic Variations and Serum Levels of Leptin and Ghrelin in Autism Spectrum Disorder.

Nehir Yazici Ö et al.

Psychiatry and Clinical Psychopharmacology, 2024

Novel NARS2 variants in a patient with early-onset status epilepticus: case study and literature review.

Yang N et al.

Bmc Pediatrics, 2024

38310242 (PubMed )
Supplement: 12887_2024_4553_MOESM1_ESM.xlsx › trio.hg38.filter

Relationship between energy balance and reward system gene polymorphisms and appetitive traits in young Mexican subjects.

Rivera-Iñiguez I et al.

Frontiers in Nutrition, 2024

Case report: An adolescent female with anosmic hypogonadotropic hypogonadism, intellectual disability, and papillary thyroid carcinoma: heterozygous deletion of TCF12.

Celik NB et al.

Frontiers in Endocrinology, 2024

The association of ghrelin rs26311 and rs27647 polymorphisms and mRNA expression with preeclampsia susceptibility and severity-A case-control study.

Montazerifar F et al.

Revista Da Associacao Medica Brasileira (1992), 2024

SNPs-Panel Polymorphism Variations in GHRL and GHSR Genes Are Not Associated with Prostate Cancer.

Merabet N et al.

Biomedicines, 2023

Rare Variants of Obesity-Associated Genes in Young Adults with Abdominal Obesity.

Bairqdar A et al.

Journal of Personalized Medicine, 2023

Functionally Significant Variants in Genes Associated with Abdominal Obesity: A Review.

Bairqdar A et al.

Journal of Personalized Medicine, 2023

Effect of the GHRL gene (rs696217) polymorphism on the metabolic disorders in patients with obesity in the Ukrainian population.

Prodan A et al.

Endocrine Regulations, 2023

GHRL, LEP, LEPR genes polymorphism and their association with the metabolic syndrome in the Ukrainian population.

Prodan A et al.

Endocrine Regulations, 2023

Leu72Met Polymorphism in Ghrelin Gene: A Potential Risk Factor for Hypertension in Type 2 Diabetes Patients.

Buraczynska M et al.

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy, 2023

Genetic analysis and prenatal diagnosis of short-rib thoracic dysplasia 3 with or without polydactyly caused by compound heterozygous variants of DYNC2H1 gene in four Chinese families.

Fang Y et al.

Frontiers in Genetics, 2023

37007936 (PubMed )
Supplement: Table1.XLS › Sheet

Melatonin receptor 1B gene rs10830963 C/G polymorphism associated with type 2 diabetes mellitus: An updated meta-analysis of 13,752 participants.

Li YY et al.

Heliyon, 2022

Role of Leu72Met of GHRL and Gln223Arg of LEPR Variants on Food Intake, Subjective Appetite, and Hunger-Satiety Hormones.

Sanchez-Murguia T et al.

Nutrients, 2022

Ghrelin polymorphism/TRPV1 receptor expression in Egyptian IBS patients.

Samy W et al.

Cytokine, 2022

Interaction between the genetic variant of rs696217-ghrelin and food intake and obesity and dyslipidemia.

Yadegari M et al.

Annals of Human Genetics, 2022

Adiponectin gene polymorphisms and risk of type 2 diabetes: an updated evidence for meta-analysis.

Alimi M et al.

Diabetology & Metabolic Syndrome, 2021

Distribution and effect of ghrelin genotype on plasma lipid and apolipoprotein profiles in obese and nonobese Chinese subjects.

Bai R et al.

Hormones (athens, Greece), 2021

The Leu72Met (rs696217 G>T) Polymorphism of the Ghrelin Gene Might Be a Protective Factor for Nonalcoholic Fatty Liver Disease.

Tabaeian SP et al.

Journal of Gastrointestinal and Liver Diseases : Jgld, 2021

Dual Effect of the GHRL Gene Variant in the Molecular Pathogenesis of Obesity.

Becer E et al.

Balkan Journal of Medical Genetics : Bjmg, 2021

Ghrelin modulates dopaminergic neuron formation and attention deficit hyperactivity disorder-like behaviors: From animals to human models.

Shi X et al.

Brain, Behavior, and Immunity, 2021

A Systematic Review of Genetic Polymorphisms Associated with Binge Eating Disorder.

Manfredi L et al.

Nutrients, 2021

Discovering Genotype Variants in an Infant with VACTERL through Clinical Exome Sequencing: A Support for Personalized Risk Assessment and Disease Prevention.

Pelizzo G et al.

Pediatric Reports, 2021

Ghrelin Gene Polymorphisms in Irritable Bowel Syndrome.

Kalli T et al.

Digestion, 2021

High-depth African genomes inform human migration and health.

Choudhury A et al.

Nature, 2020

33116287 (PubMed )
Supplement: 41586_2020_2859_MOESM3_ESM.xlsx › Supp_T19

The relationship among androgens, insulin resistance and ghrelin polymorphisms in post-adolescent male patients with severe acne vulgaris.

Pektas SD et al.

Postepy Dermatologii I Alergologii, 2020

Leu72Met polymorphism of GHRL gene decreases susceptibility to type 2 diabetes mellitus in a Mexican population.

Rivera-León EA et al.

Bmc Endocrine Disorders, 2020

Variation analysis of Ghrelin gene in Chinese patients with obesity, having polycystic ovarian syndrome.

Wang X et al.

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 2020

Reinterpretation of common pathogenic variants in ClinVar revealed a high proportion of downgrades.

Xiang J et al.

Scientific Reports, 2020

31942019 (PubMed )
Supplement: 41598_2019_57335_MOESM1_ESM.xlsx › Sup_table_1

A Metabolic Perspective on Reward Abnormalities in Anorexia Nervosa.

Duriez P et al.

Trends in Endocrinology and Metabolism: Tem, 2019

Gene-lifestyle interaction on risk of type 2 diabetes: A systematic review.

Dietrich S et al.

Obesity Reviews : an Official Journal of the International Association for the Study of Obesity, 2019

31478326 (PubMed )
Supplement: OBR-20--s001.docx

Investigation of new candidate genes in retinoblastoma using the TruSight One "clinical exome" gene panel.

Akdeniz D et al.

Molecular Genetics & Genomic Medicine, 2019

Ghrelin and aggressive behaviours-Evidence from preclinical and human genetic studies.

Vestlund J et al.

Psychoneuroendocrinology, 2019

Role of eating disorders-related polymorphisms in obesity pathophysiology.

Nicoletti CF et al.

Reviews in Endocrine & Metabolic Disorders, 2019

The preliminary investigation of orexigenic hormone gene polymorphisms on posttraumatic stress disorder symptoms.

Li G et al.

Psychoneuroendocrinology, 2019

GHRL Gene Leu72Met Polymorphism and Type 2 Diabetes Mellitus: A Meta-Analysis Involving 8,194 Participants.

Li YY et al.

Frontiers in Endocrinology, 2019

Whole-Exome Sequencing Characterized the Landscape of Somatic Mutations and Pathways in Colorectal Cancer Liver Metastasis.

Feng L et al.

Journal of Oncology, 2019

31814826 (PubMed )
Supplement: 2684075.f1.zip › 2684075.f1 › Supplemental_Table_2.xlsx › Sheet1

The Ghrelin-AgRP Neuron Nexus in Anorexia Nervosa: Implications for Metabolic and Behavioral Adaptations.

Méquinion M et al.

Frontiers in Nutrition, 2019

TP53 single nucleotide polymorphism (rs1042522) in Iranian patients with coronary artery disease.

Omrani-Nava V et al.

Biomedical Reports, 2018

Non-Synonymous Single-Nucleotide Polymorphisms and Physical Activity Interactions on Adiposity Parameters in Malaysian Adolescents.

Zaharan NL et al.

Frontiers in Endocrinology, 2018

Ethnicity-Specific Association Between Ghrelin Leu72Met Polymorphism and Type 2 Diabetes Mellitus Susceptibility: An Updated Meta-Analysis.

Huang R et al.

Frontiers in Genetics, 2018

Leu72Met and Other Intronic Polymorphisms in the GHRL and GHSR Genes Are Not Associated with Type 2 Diabetes Mellitus, Insulin Resistance, or Serum Ghrelin Levels in a Saudi Population.

Joatar FE et al.

Endocrinology and Metabolism (seoul, Korea), 2017

The Leu72Met Polymorphism of the Prepro-ghrelin Gene is Associated With Alcohol Consumption and Subjective Responses to Alcohol: Preliminary Findings.

Suchankova P et al.

Alcohol and Alcoholism (oxford, Oxfordshire), 2017

Association of A-604G ghrelin gene polymorphism and serum ghrelin levels with the risk of obesity in a mexican population.

Llamas-Covarrubias IM et al.

Molecular Biology Reports, 2017

A systematic review and meta-analysis of genetic association studies for the role of inflammation and the immune system in diabetic nephropathy.

Tziastoudi M et al.

Clinical Kidney Journal, 2017

Heterozygosity for the rs696217 SNP in the Preproghrelin Gene Predicts Weight Loss After Bariatric Surgery in Severely Obese Individuals.

Vitolo E et al.

Obesity Surgery, 2017

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."