Varaico: Literature-Extracted Genetic Variants

Gene:GHRL
Variant:p.R51Q
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GHRL

NM_016362.5:p.R51Q

Associated Papers

Distribution of Variants and Identification of Novel Variants in Patients with Obesity Using Next-Generation Sequencing in Genes Associated with Obesity: A Single-Center Experience in Turkey.

Anlas O et al.

Molecular Syndromology, 2025

The association of ghrelin rs26311 and rs27647 polymorphisms and mRNA expression with preeclampsia susceptibility and severity-A case-control study.

Montazerifar F et al.

Revista Da Associacao Medica Brasileira (1992), 2024

SNPs-Panel Polymorphism Variations in GHRL and GHSR Genes Are Not Associated with Prostate Cancer.

Merabet N et al.

Biomedicines, 2023

Association between Genotype and the Glycemic Response to an Oral Glucose Tolerance Test: A Systematic Review.

Bayer S et al.

Nutrients, 2023

37049537 (PubMed )
Supplement: nutrients-15-01695-s001.zip › Table_S1.pdf

Functionally Significant Variants in Genes Associated with Abdominal Obesity: A Review.

Bairqdar A et al.

Journal of Personalized Medicine, 2023

Leu72Met Polymorphism in Ghrelin Gene: A Potential Risk Factor for Hypertension in Type 2 Diabetes Patients.

Buraczynska M et al.

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy, 2023

Dual Effect of the GHRL Gene Variant in the Molecular Pathogenesis of Obesity.

Becer E et al.

Balkan Journal of Medical Genetics : Bjmg, 2021

Ghrelin modulates dopaminergic neuron formation and attention deficit hyperactivity disorder-like behaviors: From animals to human models.

Shi X et al.

Brain, Behavior, and Immunity, 2021

The relationship among androgens, insulin resistance and ghrelin polymorphisms in post-adolescent male patients with severe acne vulgaris.

Pektas SD et al.

Postepy Dermatologii I Alergologii, 2020

A Metabolic Perspective on Reward Abnormalities in Anorexia Nervosa.

Duriez P et al.

Trends in Endocrinology and Metabolism: Tem, 2019

GHRL Gene Leu72Met Polymorphism and Type 2 Diabetes Mellitus: A Meta-Analysis Involving 8,194 Participants.

Li YY et al.

Frontiers in Endocrinology, 2019

Assessment of coding region variants in Kuwaiti population: implications for medical genetics and population genomics.

John SE et al.

Scientific Reports, 2018

Ethnicity-Specific Association Between Ghrelin Leu72Met Polymorphism and Type 2 Diabetes Mellitus Susceptibility: An Updated Meta-Analysis.

Huang R et al.

Frontiers in Genetics, 2018

Association of plasma ghrelin levels and ghrelin rs4684677 polymorphism with mild cognitive impairment in type 2 diabetic patients.

Huang R et al.

Oncotarget, 2017

Leu72Met408 Polymorphism of the Ghrelin Gene Is Associated With Early Phase of Gastric Emptying in the Patients With Functional Dyspepsia in Japan.

Yamawaki H et al.

Journal of Neurogastroenterology and Motility, 2015

Ghrelin Gene Variants Influence on Metabolic Syndrome Components in Aged Spanish Population.

Mora M et al.

Plos One, 2015

High plasma ghrelin protects from coronary heart disease and Leu72Leu polymorphism of ghrelin gene from cancer in healthy adults during the 19 years follow-up study.

Laurila M et al.

Peptides, 2014

Polymorphisms for ghrelin with consequences on satiety and metabolic alterations.

Perret J et al.

Current Opinion in Clinical Nutrition and Metabolic Care, 2014

Association between ghrelin gene (Leu72Met) polymorphism and ghrelin serum level with coronary artery diseases.

Hedayatizadeh-Omran A et al.

Dna and Cell Biology, 2014

MTHFR and HFE, but not preproghrelin and LBP, polymorphisms as risk factors for all-cause end-stage renal disease development.

Bloudíčková S et al.

Folia Biologica, 2014

Association of genetic variants of ghrelin, leptin and UCP2 with malnutrition inflammation syndrome and survival in end-stage renal disease patients.

Sharma R et al.

Genes & Nutrition, 2013

Genetic variants associated with the progression of hepatocellular carcinoma in hepatitis C Egyptian patients.

Motawi TK et al.

Gene, 2013

A possible association between panic disorder and a polymorphism in the preproghrelingene.

Hansson C et al.

Psychiatry Research, 2013

The preproghrelin 3056 TT genotype is associated with the feeling of hunger and low acylated ghrelin levels in Japanese patients with Helicobacter pylori-negative functional dyspepsia.

Futagami S et al.

Internal Medicine (tokyo, Japan), 2013

Effects of ghrelin gene genotypes on the growth traits in Chinese cattle.

Zhang AL et al.

Molecular Biology Reports, 2012

Effect of polymorphisms at the ghrelin gene locus on carcass, microstructure and physicochemical properties of longissimus lumborum muscle of Polish Landrace pigs.

Wojtysiak D et al.

Meat Science, 2011

Genetic variants of ghrelin in metabolic disorders.

Ukkola O

Peptides, 2011

Ghrelin gene polymorphisms in rheumatoid arthritis.

Ozgen M et al.

Joint Bone Spine, 2011

No association of the neuropeptide Y (Leu7Pro) and ghrelin gene (Arg51Gln, Leu72Met, Gln90Leu) single nucleotide polymorphisms with eating disorders.

Kindler J et al.

Nordic Journal of Psychiatry, 2011

The association of ghrelin polymorphisms with coronary artery disease and ischemic chronic heart failure in an elderly Chinese population.

Zhang Q et al.

Clinical Biochemistry, 2011

Obesity and variants of the GHRL (ghrelin) and BCHE (butyrylcholinesterase) genes.

Dantas VG et al.

Genetics and Molecular Biology, 2011

Genetic association between ghrelin polymorphisms and Alzheimer's disease in a Japanese population.

Shibata N et al.

Dementia and Geriatric Cognitive Disorders, 2011

Ghrelin PYY 3-36 serum changes in left ventricular hypertrophic, insulin-resistant, hypertensive obese patients.

Karcz-Socha I et al.

Obesity Facts, 2011

Plasma ghrelin levels and polymorphisms of ghrelin gene in Chinese obese children and adolescents.

Zhu JF et al.

Irish Journal of Medical Science, 2010

PhenoHM: human-mouse comparative phenome-genome server.

Sardana D et al.

Nucleic Acids Research, 2010

20507906 (PubMed )
Supplement: gkq472_nar-00429-web-b-2010-File006.xls › MPO_to_OMIM_allelic_Variants

The ghrelin gene allele 51Q (rs34911341) is a protective factor against the development of gestational diabetes.

dos Santos IC et al.

Clinica Chimica Acta; International Journal of Clinical Chemistry, 2010

Abstracts of the First International Congress of Translational Research in Human Nutrition, March 19-20, 2010, Clermont-Ferrand, France.

Unknown Author

The Journal of Nutrition, Health & Aging, 2010

Influence of ghrelin gene polymorphisms on hypertension and atherosclerotic disease.

Berthold HK et al.

Hypertension Research : Official Journal of the Japanese Society of Hypertension, 2010

No association of the Arg51Gln and Leu72Met polymorphisms of the ghrelin gene and polycystic ovary syndrome.

Wang K et al.

Human Reproduction (oxford, England), 2009

Fasting plasma total ghrelin concentrations in monozygotic twins discordant for obesity.

Leskelä P et al.

Metabolism: Clinical and Experimental, 2009

Polymorphisms of the ghrelin/obestatin gene and ghrelin levels in Chinese children with short stature.

Zou CC et al.

Clinical Endocrinology, 2008

Association of ghrelin polymorphisms with metabolic syndrome in Han Nationality Chinese.

Xu LL et al.

Biomedical and Environmental Sciences : Bes, 2008

Lack of association of ghrelin precursor gene variants and percentage body fat or serum lipid profiles.

Martin GR et al.

Obesity (silver Spring, Md.), 2008

Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome: The Finnish Diabetes Prevention Study.

Kilpeläinen TO et al.

Metabolism: Clinical and Experimental, 2008

No association of defined variability in leptin, leptin receptor, adiponectin, proopiomelanocortin and ghrelin gene with food preferences in the Czech population.

Bienertova-Vasku J et al.

Nutritional Neuroscience, 2008

The GH1/IGF-1 axis polymorphisms and their impact on breast cancer development.

Wagner K et al.

Breast Cancer Research and Treatment, 2007

Molecular genetics of human growth hormone, insulin-like growth factors and their pathways in common disease.

Rodriguez S et al.

Human Genetics, 2007

Epistatic interaction between haplotypes of the ghrelin ligand and receptor genes influence susceptibility to myocardial infarction and coronary artery disease.

Baessler A et al.

Human Molecular Genetics, 2007

The Leu72Met polymorphism of the ghrelin gene is significantly associated with binge eating disorder.

Monteleone P et al.

Psychiatric Genetics, 2007

Ghrelin variants influence development of body mass index and plasma levels of total cholesterol in dialyzed patients.

Hubacek JA et al.

Clinical Chemistry and Laboratory Medicine, 2007

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."