Varaico: Literature-Extracted Genetic Variants

Gene:GLP1R
Variant:p.T298A
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GLP1R

NM_002062.5:p.T298A

Associated Papers

GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.

Lagou V et al.

Nature Genetics, 2023

37679419 (PubMed )
Supplement: 41588_2023_1462_MOESM6_ESM.xlsx › SuppTable12

Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation.

Koole C et al.

The Journal of Biological Chemistry, 2012

Functional coupling of Cys-226 and Cys-296 in the glucagon-like peptide-1 (GLP-1) receptor indicates a disulfide bond that is close to the activation pocket.

Mann RJ et al.

Peptides, 2010

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."