Associated Papers
Breaking the one-site myth: the multifaceted world of proton sensing in GPCRs.
Agrawal M et al.
The Febs Journal, 2025
Inflammatory bowel disease risk gene C1ORF106 regulates actin dynamics in intestinal epithelial cells.
Hébert-Milette I et al.
Biorxiv : the Preprint Server for Biology, 2025
Small-molecule probe for IBD risk variant GPR65 I231L alters cytokine signaling networks through positive allosteric modulation.
Neale I et al.
Science Advances, 2024
Role of pH-sensing receptors in colitis.
Hausmann M et al.
Pflugers Archiv : European Journal of Physiology, 2024
OGR1 (GPR68) and TDAG8 (GPR65) Have Antagonistic Effects in Models of Colonic Inflammation.
Perren L et al.
International Journal of Molecular Sciences, 2023
Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries.
Liu Z et al.
Nature Genetics, 2023
IBD-associated G protein-coupled receptor 65 variant compromises signalling and impairs key functions involved in inflammation.
Mercier V et al.
Cellular Signalling, 2022
pH and Proton Sensor GPR65 Determine Susceptibility to Atopic Dermatitis.
Xie L et al.
Journal of Immunology (baltimore, Md. : 1950), 2021
Analysis of 47 Non-MHC Ankylosing Spondylitis Susceptibility Loci Regarding Associated Variants across Whites and Han Chinese.
Zheng X et al.
The Journal of Rheumatology, 2020
Activation of pH-Sensing Receptor OGR1 (GPR68) Induces ER Stress Via the IRE1α/JNK Pathway in an Intestinal Epithelial Cell Model.
Maeyashiki C et al.
Scientific Reports, 2020
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Larabi A et al.
Autophagy, 2020
Prioritizing Crohn's disease genes by integrating association signals with gene expression implicates monocyte subsets.
Gettler K et al.
Genes and Immunity, 2019
Biological Functions of Autophagy Genes: A Disease Perspective.
Levine B et al.
Cell, 2019
Phenome-wide association studies across large population cohorts support drug target validation.
Diogo D et al.
Nature Communications, 2018
Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease.
Hui KY et al.
Science Translational Medicine, 2018
Mechanisms and function of autophagy in intestinal disease.
Lassen KG et al.
Autophagy, 2018
Fine-mapping inflammatory bowel disease loci to single-variant resolution.
Huang H et al.
Nature, 2017
Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk.
Lassen KG et al.
Immunity, 2016