Varaico: Literature-Extracted Genetic Variants

Gene:GPX1
Variant:p.P200L
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GPX1

NM_000581.4:p.P200L

Associated Papers

Variation of the genes encoding antioxidant enzymes SOD2 (rs4880), GPX1 (rs1050450), and CAT (rs1001179) and susceptibility to male infertility: a genetic association study and in silico analysis.

Fallah F et al.

Environmental Science and Pollution Research International, 2023

Bi-allelic mutation in SEC16B alters collagen trafficking and increases ER stress.

El-Gazzar A et al.

Embo Molecular Medicine, 2023

36916446 (PubMed )
Supplement: EMMM-15-e16834-s012.xlsx › WES_SEC16B_mutant

Polymorphisms of Antioxidant Enzymes SOD2 (rs4880) and GPX1 (rs1050450) Are Associated with Bladder Cancer Risk or Its Aggressiveness.

Nikic P et al.

Medicina (kaunas, Lithuania), 2023

Decoding the genetic relationship between Alzheimer's disease and type 2 diabetes: potential risk variants and future direction for North Africa.

Boukhalfa W et al.

Frontiers in Aging Neuroscience, 2023

37342358 (PubMed )
Supplement: Table_2.XLSX › Table_2_SNPnexus_annotation

Genetic susceptibility of bladder cancer in the Lebanese population.

Kourie HR et al.

Bmc Medical Genomics, 2022

36253817 (PubMed )
Supplement: 12920_2022_1372_MOESM2_ESM.xlsx › Literature_review_table

Deep whole genome sequencing identifies recurrent genomic alterations in commonly used breast cancer cell lines and patient-derived xenograft models.

Deng N et al.

Breast Cancer Research : Bcr, 2022

36153537 (PubMed )
Supplement: 13058_2022_1540_MOESM2_ESM.xlsx › SuppTableS2

Antioxidant Genetic Profile Modifies Probability of Developing Neurological Sequelae in Long-COVID.

Ercegovac M et al.

Antioxidants (basel, Switzerland), 2022

Contribution of glutathione peroxidase 1 (Pro200Leu) single nucleotide polymorphism and serum homocysteine levels in the risk of acute myocardial infarction in Egyptians.

Ismail LK et al.

Journal, Genetic Engineering & Biotechnology, 2022

Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology.

Bjornsdottir G et al.

Nature Communications, 2022

Variability in oxidative stress-related genes (SOD2, CAT, GPX1, GSTP1, NOS3, NFE2L2, and UCP2) and susceptibility to migraine clinical phenotypes and features.

Papasavva M et al.

Frontiers in Neurology, 2022

Variability of the Genes Involved in the Cellular Redox Status and Their Implication in Drug Hypersensitivity Reactions.

Ayuso P et al.

Antioxidants (basel, Switzerland), 2021

The Association of Polymorphisms in Nrf2 and Genes Involved in Redox Homeostasis in the Development and Progression of Clear Cell Renal Cell Carcinoma.

Mihailovic S et al.

Oxidative Medicine and Cellular Longevity, 2021

Umbrella Review on Associations Between Single Nucleotide Polymorphisms and Lung Cancer Risk.

Li X et al.

Frontiers in Molecular Biosciences, 2021

34540891 (PubMed )
Supplement: DataSheet1.zip › Data_Sheet_---Supplementary_Additional_file › Supplementary_Additional_file › Supplementary_Additional_file_S2.docx

Association Between Glutathione Peroxidase-1 (GPx-1) Polymorphisms and Schizophrenia in the Chinese Han Population.

Shao X et al.

Neuropsychiatric Disease and Treatment, 2020

Association of SOD2 (rs4880) and GPX1 (rs1050450) Gene Polymorphisms with Risk of Balkan Endemic Nephropathy and its Related Tumors.

Dragicevic B et al.

Medicina (kaunas, Lithuania), 2019

Genetic variability of inflammation and oxidative stress genes does not play a major role in the occurrence of adverse events of dopaminergic treatment in Parkinson's disease.

Redenšek S et al.

Journal of Neuroinflammation, 2019

30813952 (PubMed )
Supplement: 12974_2019_1439_MOESM1_ESM.docx

Catalase C-262T Polymorphism Is a Risk Factor for Valproic Acid-Induced Abnormal Liver Function in Chinese Patients With Epilepsy.

Ma L et al.

Therapeutic Drug Monitoring, 2019

Association of polymorphisms in genes coding for antioxidant enzymes and human male infertility.

García Rodríguez A et al.

Annals of Human Genetics, 2019

The redox balance of healthy Brazilian adults is associated with GPX1 Pro198Leu and -602A/G polymorphisms, selenium status, and anthropometric and lifestyle parameters.

Almondes KGS et al.

Food & Function, 2018

Diabetes mellitus, superoxide dismutase and peroxisome proliferator activated receptor gamma polymorphisms modify the outcome of end-stage renal disease patients of Han Chinese origin.

Chao CT et al.

Nephrology (carlton, Vic.), 2018

Genetic polymorphisms of antioxidant enzymes CAT and SOD affect the outcome of clinical, biochemical, and anthropometric variables in people with obesity under a dietary intervention.

Hernández-Guerrero C et al.

Genes & Nutrition, 2018

Evaluation of Glutathione Peroxidase and KCNJ11 Gene Polymorphisms in Patients with New Onset Diabetes Mellitus After Renal Transplantation.

Yalin GY et al.

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, 2017

Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity.

Choudhury Y et al.

Scientific Reports, 2017

28120901 (PubMed )
Supplement: srep41238-s1.pdf

Functional polymorphisms in antioxidant genes in Hurthle cell thyroid neoplasm - an association of GPX1 polymorphism and recurrent Hurthle cell thyroid carcinoma.

Krhin B et al.

Radiology and Oncology, 2016

The association between antioxidant enzyme polymorphisms and cerebral palsy after perinatal hypoxic-ischaemic encephalopathy.

Esih K et al.

European Journal of Paediatric Neurology : Ejpn : Official Journal of the European Paediatric Neurology Society, 2016

Antioxidant defence-related genetic variants are not associated with higher risk of secondary thyroid cancer after treatment of malignancy in childhood or adolescence.

Vodusek AL et al.

Radiology and Oncology, 2016

Genetic polymorphisms (Pro197Leu of Gpx1, +35A/C of SOD1, -262C/T of CAT), the level of antioxidant proteins (GPx1, SOD1, CAT) and the risk of distal symmetric polyneuropathy in Polish patients with type 2 diabetes mellitus.

Kasznicki J et al.

Advances in Medical Sciences, 2016

Inflammatory bowel disease (IBD) locus 12: is glutathione peroxidase-1 (GPX1) the relevant gene?

Häuser F et al.

Genes and Immunity, 2015

The rs1803274 polymorphism of the BCHE gene is associated with an increased risk of coronary in-stent restenosis.

Pleva L et al.

Bmc Cardiovascular Disorders, 2015

Lipid peroxidation and glutathione peroxidase activity relationship in breast cancer depends on functional polymorphism of GPX1.

Jablonska E et al.

Bmc Cancer, 2015

26446998 (PubMed )
Supplement: 12885_2015_1680_MOESM1_ESM.docx

Identification of cancer predisposition variants in apparently healthy individuals using a next-generation sequencing-based family genomics approach.

Karageorgos I et al.

Human Genomics, 2015

26092435 (PubMed )
Supplement: 40246_2015_34_MOESM1_ESM.xlsx › FamilyA

Association of Superoxide dismutases (SOD1 and SOD2) and Glutathione peroxidase 1 (GPx1) gene polymorphisms with type 2 diabetes mellitus.

Vats P et al.

Free Radical Research, 2015

Pro198Leu polymorphism in the oxidative stress gene, glutathione peroxidase-1, is associated with a gender-specific risk for panic disorder.

Cengiz M et al.

International Journal of Psychiatry in Clinical Practice, 2015

Influence of GSTO2 (N142D) genetic polymorphism on acute renal rejection.

Nekooie-Marnany N et al.

Molecular Biology Reports, 2013

Impact of genetic polymorphisms on adenoma recurrence and toxicity in a COX2 inhibitor (celecoxib) trial: results from a pilot study.

Kraus S et al.

Pharmacogenetics and Genomics, 2013

Next generation exome sequencing of paediatric inflammatory bowel disease patients identifies rare and novel variants in candidate genes.

Christodoulou K et al.

Gut, 2013

22543157 (PubMed )
Supplement: gutjnl-2011-301833-s1.pdf

Variation in selenoenzyme genes and prostate cancer risk and survival.

Geybels MS et al.

The Prostate, 2013

GPX1 gene Pro200Leu polymorphism, erythrocyte GPX activity, and cancer risk.

Hong Z et al.

Molecular Biology Reports, 2013

Association of SOD2, GPX1, CAT, and TNF genetic polymorphisms with oxidative stress, neurochemistry, psychopathology, and extrapyramidal symptoms in schizophrenia.

Bošković M et al.

Neurochemical Research, 2013

The impact of GPX1 on the association of groundwater selenium and depression: a Project FRONTIER study.

Johnson LA et al.

Bmc Psychiatry, 2013

Association study of polymorphisms in selenoprotein genes and Kashin-Beck disease and serum selenium/iodine concentration in a Tibetan population.

Huang L et al.

Plos One, 2013

Association between polymorphisms of eNOS and GPx-1 genes, activity of free-radical processes and in-stent restenosis.

Shuvalova YA et al.

Molecular and Cellular Biochemistry, 2012

Influence of the glutathione peroxidase 1 Pro200Leu polymorphism on the response of glutathione peroxidase activity to selenium supplementation: a randomized controlled trial.

Miller JC et al.

The American Journal of Clinical Nutrition, 2012

Antioxidant enzyme polymorphisms and neuropsychological outcomes in medulloblastoma survivors: a report from the Childhood Cancer Survivor Study.

Brackett J et al.

Neuro-oncology, 2012

Glutathione peroxidase tagSNPs: associations with rectal cancer but not with colon cancer.

Haug U et al.

Genes, Chromosomes & Cancer, 2012

Genetic variation in GPX1 is associated with GPX1 activity in a comprehensive analysis of genetic variations in selenoenzyme genes and their activity and oxidative stress in humans.

Takata Y et al.

The Journal of Nutrition, 2012

Genetic polymorphisms in DNA repair and oxidative stress pathways associated with malignant melanoma susceptibility.

Ibarrola-Villava M et al.

European Journal of Cancer (oxford, England : 1990), 2011

Polymorphisms of antioxidant enzymes, blood pressure and risk of hypertension.

Mansego ML et al.

Journal of Hypertension, 2011

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."