Varaico: Literature-Extracted Genetic Variants

Gene:GRID2
Variant:p.E218D
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GRID2

NM_001510.4:p.E218D

Associated Papers

Glutamate Delta 1 Receptor in Synapses, Circuits, and Disease.

Choi D et al.

The European Journal of Neuroscience, 2026

Rescuing Neurodevelopmental Deficits in AMPA Receptor Gain-of-Function Mutant.

Chen CM et al.

Biorxiv : the Preprint Server for Biology, 2025

GluD1 at the synaptic crossroads: from domain structure to circuit dysfunction.

Chettiar PB et al.

Acta Pharmacologica Sinica, 2025

Delta-type glutamate receptors are ligand-gated ion channels.

Wang H et al.

Nature, 2025

Loss of activation by GABA in vertebrate delta ionotropic glutamate receptors.

Rosano G et al.

Proceedings of the National Academy of Sciences of the United States of America, 2024

Clinical features, functional consequences, and rescue pharmacology of missense GRID1 and GRID2 human variants.

Allen JP et al.

Human Molecular Genetics, 2024

Neurodevelopmental Syndrome with Intellectual Disability, Speech Impairment, and Quadrupedia Is Associated with Glutamate Receptor Delta 2 Gene Defect.

Grigorenko AP et al.

Cells, 2022

Delta glutamate receptors are functional glycine- and ᴅ-serine-gated cation channels in situ.

Carrillo E et al.

Science Advances, 2021

An emerging map of glutamate delta 1 receptors in the forebrain.

Andrews PC et al.

Neuropharmacology, 2021

Probing the ionotropic activity of glutamate GluD2 receptor in HEK cells with genetically-engineered photopharmacology.

Lemoine D et al.

Elife, 2020

The low binding affinity of D-serine at the ionotropic glutamate receptor GluD2 can be attributed to the hinge region.

Tapken D et al.

Scientific Reports, 2017

Glutamate receptor ion channels: structure, regulation, and function.

Traynelis SF et al.

Pharmacological Reviews, 2010

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."