Associated Papers
GRK phosphorylation drives β-arrestin-independent internalization of chemokine receptor CXCR5.
Crecelius JM et al.
The Journal of Biological Chemistry, 2025
Discriminating activating, deactivating and resistance variants in protein kinases.
Singh G et al.
Genome Medicine, 2025
β-Arrestin mediates the export of ciliary GPR161 but not Smoothened together with the BBSome and intraflagellar transport machinery.
Fujii T et al.
Journal of Cell Science, 2025
GRK2-mediated AKT activation controls cell cycle progression and G2 checkpoint in a p53-dependent manner.
Rivas V et al.
Cell Death Discovery, 2024
Role of G protein-coupled receptor kinases (GRKs) in β2 -adrenoceptor-mediated glucose uptake.
Ham S et al.
Pharmacology Research & Perspectives, 2024
Dynamic RBM47 ISGylation confers broad immunoprotection against lung injury and tumorigenesis via TSC22D3 downregulation.
Ding S et al.
Cell Death Discovery, 2023
MRAP2 inhibits β-arrestin recruitment to the ghrelin receptor by preventing GHSR1a phosphorylation.
Rouault AAJ et al.
The Journal of Biological Chemistry, 2022
Delineating the interactions between the cannabinoid CB2 receptor and its regulatory effectors; β-arrestins and GPCR kinases.
Patel M et al.
British Journal of Pharmacology, 2022
Mechanisms of differential desensitization of metabotropic glutamate receptors.
Abreu N et al.
Cell Reports, 2021
Different phosphorylation patterns regulate α1D-adrenoceptor signaling and desensitization.
Alfonzo-Méndez MA et al.
Biochimica Et Biophysica Acta. Molecular Cell Research, 2018
An essential role for Grk2 in Hedgehog signalling downstream of Smoothened.
Zhao Z et al.
Embo Reports, 2016
Protein Kinase C ζ Interacts with a Novel Binding Region of Gαq to Act as a Functional Effector.
Sánchez-Fernández G et al.
The Journal of Biological Chemistry, 2016
Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor.
Cooke AE et al.
British Journal of Pharmacology, 2015
Mapping the putative G protein-coupled receptor (GPCR) docking site on GPCR kinase 2: insights from intact cell phosphorylation and recruitment assays.
Beautrait A et al.
The Journal of Biological Chemistry, 2014
Desensitization and internalization of endothelin receptor A: impact of G protein-coupled receptor kinase 2 (GRK2)-mediated phosphorylation.
Gärtner F et al.
The Journal of Biological Chemistry, 2013
G protein-coupled receptor kinase 2 (GRK2) is localized to centrosomes and mediates epidermal growth factor-promoted centrosomal separation.
So CH et al.
Molecular Biology of the Cell, 2013
Molecular biology of the kisspeptin receptor: signaling, function, and mutations.
Bianco SD et al.
Advances in Experimental Medicine and Biology, 2013
Regulation of Constitutive GPR3 Signaling and Surface Localization by GRK2 and β-arrestin-2 Overexpression in HEK293 Cells.
Lowther KM et al.
Plos One, 2013
Growth inhibition of human hepatocellular carcinoma cells by overexpression of G-protein-coupled receptor kinase 2.
Wei Z et al.
Journal of Cellular Physiology, 2012
Structural domains required for Caenorhabditis elegans G protein-coupled receptor kinase 2 (GRK-2) function in vivo.
Wood JF et al.
The Journal of Biological Chemistry, 2012
Regulation of the epithelial Na+ channel by the RH domain of G protein-coupled receptor kinase, GRK2, and Galphaq/11.
Lee IH et al.
The Journal of Biological Chemistry, 2011
Characterization of C-terminal tail determinants involved in CRTH2 receptor trafficking: identification of a recycling motif.
Roy SJ et al.
European Journal of Pharmacology, 2010
Role of helix 8 of the thyrotropin-releasing hormone receptor in phosphorylation by G protein-coupled receptor kinase.
Gehret AU et al.
Molecular Pharmacology, 2010
Differences in the C-terminus contribute to variations in trafficking between rat and human 5-HT(2A) receptor isoforms: identification of a primate-specific tripeptide ASK motif that confers GRK-2 and beta arrestin-2 interactions.
Bhattacharya A et al.
Journal of Neurochemistry, 2010
Kinase activity-independent regulation of cyclin pathway by GRK2 is essential for zebrafish early development.
Jiang X et al.
Proceedings of the National Academy of Sciences of the United States of America, 2009
Agonist-promoted Lys63-linked polyubiquitination of the human kappa-opioid receptor is involved in receptor down-regulation.
Li JG et al.
Molecular Pharmacology, 2008
Regulation of human melanocortin 1 receptor signaling and trafficking by Thr-308 and Ser-316 and its alteration in variant alleles associated with red hair and skin cancer.
Sánchez-Laorden BL et al.
The Journal of Biological Chemistry, 2007
A Ser/Thr cluster within the C-terminal domain of the rat prostaglandin receptor EP3alpha is essential for agonist-induced phosphorylation, desensitization and internalization.
Neuschäfer-Rube F et al.
British Journal of Pharmacology, 2005
Phosphorylation-independent regulation of metabotropic glutamate receptor 1 signaling requires g protein-coupled receptor kinase 2 binding to the second intracellular loop.
Dhami GK et al.
The Journal of Biological Chemistry, 2005
Bimodal regulation of the human H1 histamine receptor by G protein-coupled receptor kinase 2.
Iwata K et al.
The Journal of Biological Chemistry, 2005
Characterization of the GRK2 binding site of Galphaq.
Day PW et al.
The Journal of Biological Chemistry, 2004
Serine residues 338 and 339 in the carboxyl-terminal tail of the type II gonadotropin-releasing hormone receptor are critical for beta-arrestin-independent internalization.
Ronacher K et al.
Endocrinology, 2004
Increased expression of G-protein-coupled receptor kinases 3 and 4 in hyperfunctioning thyroid nodules.
Voigt C et al.
The Journal of Endocrinology, 2004
Identification of a Ser/Thr cluster in the C-terminal domain of the human prostaglandin receptor EP4 that is essential for agonist-induced beta-arrestin1 recruitment but differs from the apparent principal phosphorylation site.
Neuschäfer-Rube F et al.
The Biochemical Journal, 2004
G Protein-coupled receptor kinase 2 regulator of G protein signaling homology domain binds to both metabotropic glutamate receptor 1a and Galphaq to attenuate signaling.
Dhami GK et al.
The Journal of Biological Chemistry, 2004
Analysis of G-protein-coupled receptor kinase RGS homology domains.
Day PW et al.
Methods in Enzymology, 2004
Development of a yeast bioassay to characterize G protein-coupled receptor kinases. Identification of an NH2-terminal region essential for receptor phosphorylation.
Noble B et al.
The Journal of Biological Chemistry, 2003
Differential interaction of GRK2 with members of the G alpha q family.
Day PW et al.
Biochemistry, 2003
G-protein-coupled receptor (GPCR) kinase phosphorylation and beta-arrestin recruitment regulate the constitutive signaling activity of the human cytomegalovirus US28 GPCR.
Miller WE et al.
The Journal of Biological Chemistry, 2003
Regulation of melanocortin-4 receptor signaling: agonist-mediated desensitization and internalization.
Shinyama H et al.
Endocrinology, 2003
Regulation of phosducin-like protein by casein kinase 2 and N-terminal splicing.
Humrich J et al.
The Journal of Biological Chemistry, 2003
Surface expression and endocytosis of the human cytomegalovirus-encoded chemokine receptor US28 is regulated by agonist-independent phosphorylation.
Mokros T et al.
The Journal of Biological Chemistry, 2002
Association of chemokine-mediated block to HIV entry with coreceptor internalization.
Brandt SM et al.
The Journal of Biological Chemistry, 2002
Inverse agonist up-regulates the constitutively active D3.49(164)Q mutant of the rat mu-opioid receptor by stabilizing the structure and blocking constitutive internalization and down-regulation.
Li J et al.
Molecular Pharmacology, 2001
Role of the differentially spliced carboxyl terminus in thromboxane A2 receptor trafficking: identification of a distinct motif for tonic internalization.
Parent JL et al.
The Journal of Biological Chemistry, 2001
Internalization of the TXA2 receptor alpha and beta isoforms. Role of the differentially spliced cooh terminus in agonist-promoted receptor internalization.
Parent JL et al.
The Journal of Biological Chemistry, 1999