Associated Papers
Discriminating activating, deactivating and resistance variants in protein kinases.
Singh G et al.
Genome Medicine, 2025
Genetic variants of accessory proteins and G proteins in human genetic disease.
Thompson MD et al.
Critical Reviews in Clinical Laboratory Sciences, 2025
Kinase Activity Is Not Required for G Protein-Coupled Receptor Kinase 4 Restraining mTOR Signaling during Cilia and Kidney Development.
Gerhards J et al.
Journal of the American Society of Nephrology : Jasn, 2023
Dopamine Receptor D1R and D3R and GRK4 Interaction in Hypertension.
Zeng C et al.
The Yale Journal of Biology and Medicine, 2023
Comprehensive Assessment of Indian Variations in the Druggable Kinome Landscape Highlights Distinct Insights at the Sequence, Structure and Pharmacogenomic Stratum.
Panda G et al.
Frontiers in Pharmacology, 2022
Associations of SUCNR1, GRK4, CAMK1D gene polymorphisms and the susceptibility of type 2 diabetes mellitus and essential hypertension in a northern Chinese Han population.
Du B et al.
Journal of Diabetes and Its Complications, 2021
The Hypertension Related Gene G-Protein Coupled Receptor Kinase 4 Contributes to Breast Cancer Proliferation.
Yue W et al.
Breast Cancer : Basic and Clinical Research, 2021
Pharmacogenomics of Hypertension Treatment.
Rysz J et al.
International Journal of Molecular Sciences, 2020
Non-additive effects of ACVR2A in preeclampsia in a Philippine population.
Amosco MD et al.
Bmc Pregnancy and Childbirth, 2019
Assessment of coding region variants in Kuwaiti population: implications for medical genetics and population genomics.
John SE et al.
Scientific Reports, 2018
High Frequency of Variants of Candidate Genes in Black Africans with Low Renin-Resistant Hypertension.
Jones ES et al.
American Journal of Hypertension, 2017
The impacts of the interaction of genetic variation, CYP11β2 and NEDD4L, with sodium intake on pediatric obesity with gender difference: a 3-year panel study.
Lee M et al.
International Journal of Obesity (2005), 2017
Cardiovascular pharmacogenetics: a promise for genomically-guided therapy and personalized medicine.
Zaiou M et al.
Clinical Genetics, 2017
Common variants of the G protein-coupled receptor type 4 are associated with human essential hypertension and predict the blood pressure response to angiotensin receptor blockade.
Sanada H et al.
The Pharmacogenomics Journal, 2016
Human GRK4γ142V Variant Promotes Angiotensin II Type I Receptor-Mediated Hypertension via Renal Histone Deacetylase Type 1 Inhibition.
Wang Z et al.
Hypertension (dallas, Tex. : 1979), 2016
Association between GRK4 and DRD1 gene polymorphisms and hypertension: a meta-analysis.
Zhang H et al.
Clinical Interventions in Aging, 2016
Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4.
Allen SJ et al.
The Journal of Biological Chemistry, 2015
The importance of G protein-coupled receptor kinase 4 (GRK4) in pathogenesis of salt sensitivity, salt sensitive hypertension and response to antihypertensive treatment.
Rayner B et al.
International Journal of Molecular Sciences, 2015
Gender-based differences on the association between salt-sensitive genes and obesity in Korean children aged between 8 and 9 years.
Lee M et al.
Plos One, 2015
Genomics and pharmacogenomics of salt-sensitive hypertension Minireview.
Armando I et al.
Current Hypertension Reviews, 2015
G-protein receptor kinase 4 polymorphism and response to antihypertensive therapy.
Muskalla AM et al.
Clinical Chemistry, 2014
Salt sensitivity of blood pressure is associated with polymorphisms in the sodium-bicarbonate cotransporter.
Carey RM et al.
Hypertension (dallas, Tex. : 1979), 2012
G protein receptor kinase 4 polymorphisms: β-blocker pharmacogenetics and treatment-related outcomes in hypertension.
Vandell AG et al.
Hypertension (dallas, Tex. : 1979), 2012
G-protein-coupled receptor kinase 4 polymorphisms predict blood pressure response to dietary modification in Black patients with mild-to-moderate hypertension.
Rayner B et al.
Journal of Human Hypertension, 2012
Analysis of population genetic structure from Bucaramanga (Colombia) based on gene polymorphisms associated with the regulation of blood pressure.
León FJ et al.
Colombia Medica (cali, Colombia), 2012
Hypertension-Related Gene Polymorphisms of G-Protein-Coupled Receptor Kinase 4 Are Associated with NT-proBNP Concentration in Normotensive Healthy Adults.
Yatabe J et al.
International Journal of Hypertension, 2012
Pooled analyses of the associations of polymorphisms in the GRK4 and EMILIN1 genes with hypertension risk.
Liu C et al.
International Journal of Medical Sciences, 2012
Impact of genomic polymorphism on arterial hypertension after aortic coarctation repair.
Hager A et al.
International Journal of Cardiology, 2011
Genetics of salt-sensitive hypertension.
Sanada H et al.
Current Hypertension Reports, 2011
Variants in genes involved in functional pathways associated with hypertension in African Americans.
Martinez Cantarin MP et al.
Clinical and Translational Science, 2010
Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study.
Irvin MR et al.
Journal of Hypertension, 2010
HK-2 human renal proximal tubule cells as a model for G protein-coupled receptor kinase type 4-mediated dopamine 1 receptor uncoupling.
Gildea JJ et al.
Hypertension (dallas, Tex. : 1979), 2010
G protein-coupled receptor kinase 4 gene variants are not associated with preeclampsia in Northern Han Chinese.
Sun CJ et al.
Hypertension Research : Official Journal of the Japanese Society of Hypertension, 2010
Sodium sensitivity of blood pressure in Chinese populations.
Chen J
Current Hypertension Reports, 2010
Characterization and functional analyses of the human G protein-coupled receptor kinase 4 gene promoter.
Hasenkamp S et al.
Hypertension (dallas, Tex. : 1979), 2008
Blood pressure and renal sodium handling in relation to genetic variation in the DRD1 promoter and GRK4.
Staessen JA et al.
Hypertension (dallas, Tex. : 1979), 2008
Polymorphisms in multiple genes are associated with resting heart rate in a stepwise allele-dependent manner.
Wilton SB et al.
Heart Rhythm, 2008
G protein-coupled receptor kinase 4gamma interacts with inactive Galpha(s) and Galpha13.
Keever LB et al.
Biochemical and Biophysical Research Communications, 2008
Pharmacogenomics of G protein-coupled receptor signaling: insights from health and disease.
Thompson MD et al.
Methods in Molecular Biology (clifton, N.j.), 2008
Genetics of salt-sensitive hypertension.
Strazzullo P et al.
Current Hypertension Reports, 2007
C-reactive protein, an 'intermediate phenotype' for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loci.
Wessel J et al.
Journal of Hypertension, 2007
Association study of G protein-coupled receptor kinase 4 gene variants with essential hypertension in northern Han Chinese.
Wang Y et al.
Annals of Human Genetics, 2006
The G protein-coupled receptor kinase 4 gene modulates stress-induced sodium excretion in black normotensive adolescents.
Zhu H et al.
Pediatric Research, 2006
Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension.
Sanada H et al.
Clinical Chemistry, 2006
Patterns of genetic variation in the hypertension candidate gene GRK4: ethnic variation and haplotype structure.
Lohmueller KE et al.
Annals of Human Genetics, 2006
The G protein-coupled receptor kinase 4 gene affects blood pressure in young normotensive twins.
Zhu H et al.
American Journal of Hypertension, 2006
Functional genomics of the dopaminergic system in hypertension.
Zeng C et al.
Physiological Genomics, 2004
Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension.
Speirs HJ et al.
Journal of Hypertension, 2004