Varaico: Literature-Extracted Genetic Variants

Gene:GSK3B
Variant:p.K85R
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GSK3B

NM_001146156.2:p.K85R

Associated Papers

Dual targeting of Keap1 and Gsk-3 by hexaraphane in the regulation of transcription factor Nrf2.

García-Yagüe ÁJ et al.

Free Radical Biology & Medicine, 2025

Monoallelic loss-of-function variants in GSK3B lead to autism and developmental delay.

Tan S et al.

Molecular Psychiatry, 2025

Microsecond molecular dynamics simulations and dynamic network analysis provide understanding of the allosteric inactivation of GSK3β induced by the L343R mutation.

Li J et al.

Journal of Molecular Modeling, 2019

Role of microtubule-associated protein tau phosphorylation in Alzheimer's disease.

Ma RH et al.

Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban, 2017

Glucose-induced β-catenin acetylation enhances Wnt signaling in cancer.

Chocarro-Calvo A et al.

Molecular Cell, 2013

Effect of double mutations K214/A-E215/Q of FRATide on GSK3β: insights from molecular dynamics simulation and normal mode analysis.

Lu SY et al.

Amino Acids, 2012

Mechanism of kinase inactivation and nonbinding of FRATide to GSK3β due to K85M mutation: molecular dynamics simulation and normal mode analysis.

Lu S et al.

Biopolymers, 2011

Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling.

Chen T et al.

The Journal of Biological Chemistry, 2009

The glycogen synthase kinase (GSK) 3beta represses RNA polymerase I transcription.

Vincent T et al.

Oncogene, 2008

Nuclear GSK-3beta inhibits the canonical Wnt signalling pathway in a beta-catenin phosphorylation-independent manner.

Caspi M et al.

Oncogene, 2008

GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome.

Fumoto K et al.

The Embo Journal, 2006

The proinvasive activity of Wnt-2 is mediated through a noncanonical Wnt pathway coupled to GSK-3beta and c-Jun/AP-1 signaling.

Le Floch N et al.

Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2005

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."