Varaico: Literature-Extracted Genetic Variants

Gene:GSPT1
Variant:p.G575A
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GSPT1

NM_002094.4:p.G575A

Associated Papers

Inhibition of mTOR Enhances the Efficacy of Proteasome-Dependent Targeted Protein Degradation Approaches.

Liu Y et al.

Cancer Research, 2026

Degradation of GSPT1 causes TP53-independent cell death in leukemia while sparing normal hematopoietic stem cells.

Sellar RS et al.

The Journal of Clinical Investigation, 2022

A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.

Matyskiela ME et al.

Nature, 2016

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."