Varaico: Literature-Extracted Genetic Variants

Gene:GSTO1
Variant:p.E208K
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GSTO1

NM_004832.3:p.E208K

Associated Papers

Airways glutathione S-transferase omega-1 and its A140D polymorphism are associated with severity of inflammation and respiratory dysfunction in cystic fibrosis.

Piaggi S et al.

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society, 2021

Association between polymorphisms in arsenic metabolism genes and urinary arsenic methylation profiles in girls and boys chronically exposed to arsenic.

Recio-Vega R et al.

Environmental and Molecular Mutagenesis, 2016

Structure, function and disease relevance of Omega-class glutathione transferases.

Board PG et al.

Archives of Toxicology, 2016

Low-copper diet as a preventive strategy for Alzheimer's disease.

Squitti R et al.

Neurobiology of Aging, 2014

GSTO1 uncommon genetic variants are associated with recurrent miscarriage risk.

Polimanti R et al.

Fertility and Sterility, 2014

A role for glutathione transferase Omega 1 (GSTO1-1) in the glutathionylation cycle.

Menon D et al.

The Journal of Biological Chemistry, 2013

Genetic variability of glutathione S-transferase enzymes in human populations: functional inter-ethnic differences in detoxification systems.

Polimanti R et al.

Gene, 2013

A combined proteomic and genetic analysis of the highly variable platelet proteome: from plasmatic proteins and SNPs.

Veitinger M et al.

Journal of Proteomics, 2012

Lack of association between essential hypertension and GSTO1 uncommon genetic variants in Italian patients.

Polimanti R et al.

Genetic Testing and Molecular Biomarkers, 2012

Association of glutathione S-transferase Ω 1-1 polymorphisms (A140D and E208K) with the expression of interleukin-8 (IL-8), transforming growth factor beta (TGF-β), and apoptotic protease-activating factor 1 (Apaf-1) in humans chronically exposed to arsenic in drinking water.

Escobar-García DM et al.

Archives of Toxicology, 2012

GSTO1*E155del polymorphism associated with increased risk for late-onset Alzheimer's disease: association hypothesis for an uncommon genetic variant.

Piacentini S et al.

Neuroscience Letters, 2012

Gene polymorphisms of glutathione S-transferase omega 1 and 2, urinary arsenic methylation profile and urothelial carcinoma.

Chung CJ et al.

The Science of the Total Environment, 2011

Human GST loci as markers of evolutionary forces: GSTO1*E155del and GSTO1*E208K polymorphisms may be under natural selection induced by environmental arsenic.

Polimanti R et al.

Disease Markers, 2011

Glutathione S-transferase ω class (GSTO) polymorphisms in a sample from Rome (Central Italy).

Polimanti R et al.

Annals of Human Biology, 2010

GSTA1, GSTO1 and GSTO2 gene polymorphisms in Italian asthma patients.

Polimanti R et al.

Clinical and Experimental Pharmacology & Physiology, 2010

Genetic polymorphism of As3MT and delayed urinary DMA excretion after organic arsenic intake from oyster ingestion.

Hwang YH et al.

Journal of Environmental Monitoring : Jem, 2010

Genetic polymorphisms in glutathione S-transferase (GST) superfamily and arsenic metabolism in residents of the Red River Delta, Vietnam.

Agusa T et al.

Toxicology and Applied Pharmacology, 2010

Diversity of glutathione s-transferase omega 1 (a140d) and 2 (n142d) gene polymorphisms in worldwide populations.

Takeshita H et al.

Clinical and Experimental Pharmacology & Physiology, 2009

Ethnic differences in five intronic polymorphisms associated with arsenic metabolism within human arsenic (+3 oxidation state) methyltransferase (AS3MT) gene.

Fujihara J et al.

Toxicology and Applied Pharmacology, 2009

Polymorphisms of Glutathione S-transferases Omega-1 among ethnic populations in China.

Fu S et al.

Bmc Genetics, 2008

Genetic variants associated with arsenic susceptibility: study of purine nucleoside phosphorylase, arsenic (+3) methyltransferase, and glutathione S-transferase omega genes.

De Chaudhuri S et al.

Environmental Health Perspectives, 2008

Polymorphism of glutathione transferase Omega 1 in a population exposed to a high environmental arsenic burden.

Paiva L et al.

Pharmacogenetics and Genomics, 2008

Deletion of Glu155 causes a deficiency of glutathione transferase Omega 1-1 but does not alter sensitivity to arsenic trioxide and other cytotoxic drugs.

Schmuck E et al.

The International Journal of Biochemistry & Cell Biology, 2008

Developmental and genetic modulation of arsenic biotransformation: a gene by environment interaction?

Meza M et al.

Toxicology and Applied Pharmacology, 2007

A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.

Harris SE et al.

Bmc Genetics, 2007

17601350 (PubMed )
Supplement: 1471-2156-8-43-S1.doc

Genetic polymorphisms influencing arsenic metabolism: evidence from Argentina.

Schläwicke Engström K et al.

Environmental Health Perspectives, 2007

Frequency of two human glutathione-S-transferase omega-1 polymorphisms (E155 deletion and E208K) in Ovambo and Japanese populations using the PCR-based genotyping method.

Fujihara J et al.

Clinical Chemistry and Laboratory Medicine, 2007

Glutathione S-transferase omega 1 and omega 2 pharmacogenomics.

Mukherjee B et al.

Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2006

Characterization of the monomethylarsonate reductase and dehydroascorbate reductase activities of Omega class glutathione transferase variants: implications for arsenic metabolism and the age-at-onset of Alzheimer's and Parkinson's diseases.

Schmuck EM et al.

Pharmacogenetics and Genomics, 2005

Polymorphisms in the human monomethylarsonic acid (MMA V) reductase/hGSTO1 gene and changes in urinary arsenic profiles.

Marnell LL et al.

Chemical Research in Toxicology, 2003

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."