Varaico: Literature-Extracted Genetic Variants

Gene:GTF2I
Variant:p.L424H
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GTF2I

NM_032999.4:p.L424H

Associated Papers

Integrative Multi-omic Classification Reveals Distinct Origins and Evolutionary Trajectories of Thymic Epithelial Tumors.

Park S et al.

Cancer Research, 2026

Genome-wide analysis of somatic noncoding mutation patterns and mitochondrial heteroplasmic shift in type B1 and B2 thymomas.

Fujikura K et al.

The Journal of Pathology, 2026

Longitudinal Genomic Analysis of Five Cases of Recurrent Thymomas.

He Y et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2025

Genomic landscape and molecularly informed therapy in thymic carcinoma and other advanced thymic epithelial tumors.

Möhrmann L et al.

Med (new York, N.y.), 2025

GTF2I acts as a novel tumor suppressor transcription factor and shows Favorable prognosis in renal cancer.

Dakal TC et al.

Integrative Biology : Quantitative Biosciences From Nano to Macro, 2025

The Molecular Landscape of Thymic Epithelial Tumors: A Comprehensive Review.

Elm L et al.

International Journal of Molecular Sciences, 2024

GTF2I mutation in micronodular thymoma with lymphoid stroma.

Bille A et al.

Journal of Clinical Pathology, 2024

Insights into molecular aspects and targeted therapy of thymic carcinoma: a narrative review.

Sakane T et al.

Mediastinum (hong Kong, China), 2024

Unique correlation between GTF2I mutation and spindle cell morphology in thymomas (type A and AB thymomas).

Wells K et al.

Journal of Clinical Pathology, 2023

Genetic profile of thymic epithelial tumors in the Japanese population: an exploratory study examining potential therapeutic targets.

Shimada M et al.

Translational Lung Cancer Research, 2023

Molecular profiling of rare thymoma using next-generation sequencing: meta-analysis.

Kostic Peric J et al.

Radiology and Oncology, 2023

Identification of T Cell Receptors Targeting a Neoantigen Derived from Recurrently Mutated FGFR3.

Tate T et al.

Cancers, 2023

36831375 (PubMed )
Supplement: cancers-15-01031-s001.zip › Supplementary_Table_S1.xlsx › Table_S1

Somatic mutations of thymic epithelial tumors with myasthenia gravis.

Pardini E et al.

Frontiers in Oncology, 2023

Unraveling molecular networks in thymic epithelial tumors: deciphering the unique signatures.

Zhang X et al.

Frontiers in Immunology, 2023

A Knock-In Mouse Model of Thymoma With the GTF2I L424H Mutation.

He Y et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2022

Reply to Dr. Goto's Letter: "A Thymoma Mouse Model Harboring a Gtf2i L424H Mutation".

He Y et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2022

Human thymoma-associated mutation of the GTF2I transcription factor impairs thymic epithelial progenitor differentiation in mice.

Giorgetti OB et al.

Communications Biology, 2022

Novel Driver Strength Index highlights important cancer genes in TCGA PanCanAtlas patients.

Belikov AV et al.

Peerj, 2022

A primary thymic adenocarcinoma with two components that traced distinct evolutionary trajectories.

Ishida A et al.

Pathology International, 2021

Role of the multifunctional transcription factor TFII-I in DNA damage repair.

Roy AL

Dna Repair, 2021

Multiomics data reveals the influences of myasthenia gravis on thymoma and its precision treatment.

Ruan X et al.

Journal of Cellular Physiology, 2021

Molecular pathology of thymomas: implications for diagnosis and therapy.

Marx A et al.

Virchows Archiv : an International Journal of Pathology, 2021

Transcriptomic and Mutational Analysis Discovering Distinct Molecular Characteristics Among Chinese Thymic Epithelial Tumor Patients.

Liang N et al.

Frontiers in Oncology, 2021

Primary Driver Mutations in GTF2I Specific to the Development of Thymomas.

Higuchi R et al.

Cancers, 2020

Mutant GTF2I induces cell transformation and metabolic alterations in thymic epithelial cells.

Kim IK et al.

Cell Death and Differentiation, 2020

Metaplastic thymoma: a distinctive thymic neoplasm characterized by YAP1-MAML2 gene fusions.

Vivero M et al.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 2020

HLA class I restricted epitopes prediction of common tumor antigens in white and East Asian populations: Implication on antigen selection for cancer vaccine design.

Hu W et al.

Plos One, 2020

32106223 (PubMed )
Supplement: pone.0229327.s001.xlsx › mutation_abbreviation

Using somatic variant richness to mine signals from rare variants in the cancer genome.

Chakraborty S et al.

Nature Communications, 2019

31796730 (PubMed )
Supplement: 41467_2019_13402_MOESM1_ESM.pdf

CHASMplus Reveals the Scope of Somatic Missense Mutations Driving Human Cancers.

Tokheim C et al.

Cell Systems, 2019

Analysis of error profiles in deep next-generation sequencing data.

Ma X et al.

Genome Biology, 2019

30867008 (PubMed )
Supplement: 13059_2019_1659_MOESM1_ESM.xlsx › S3_b

The Integrated Genomic Landscape of Thymic Epithelial Tumors.

Radovich M et al.

Cancer Cell, 2018

A specific missense mutation in GTF2I occurs at high frequency in thymic epithelial tumors.

Petrini I et al.

Nature Genetics, 2014

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."