Varaico: Literature-Extracted Genetic Variants

Gene:H2AC20
Variant:p.K119R
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H2AC20

NM_003517.3:p.K119R

Associated Papers

Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168.

Ai H et al.

Nature Chemical Biology, 2025

H2B oncohistones cause homologous recombination defect and genomic instability through reducing H2B monoubiquitination in Schizosaccharomyces pombe.

Qin B et al.

The Journal of Biological Chemistry, 2024

Dynamic switching of crotonylation to ubiquitination of H2A at lysine 119 attenuates transcription-replication conflicts caused by replication stress.

Hao S et al.

Nucleic Acids Research, 2022

Histone H2B Ubiquitylation Regulates Histone Gene Expression by Suppressing Antisense Transcription in Fission Yeast.

Pagé V et al.

Genetics, 2019

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones.

Masclef L et al.

Journal of Visualized Experiments : Jove, 2019

Regulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC1.

Zhang Y et al.

Cell Cycle (georgetown, Tex.), 2019

The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation.

Lee HS et al.

Nature Communications, 2018

Dissecting Nucleosome Function with a Comprehensive Histone H2A and H2B Mutant Library.

Jiang S et al.

G3 (bethesda, Md.), 2017

29038170 (PubMed )
Supplement: 3857TableS3.xlsx › H2_plate1

The histone H2A deubiquitinase USP16 interacts with HERC2 and fine-tunes cellular response to DNA damage.

Zhang Z et al.

The Journal of Biological Chemistry, 2014

BRCA1 is a histone-H2A-specific ubiquitin ligase.

Kalb R et al.

Cell Reports, 2014

25131202 (PubMed )
Supplement: mmc1.pdf

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark.

Fradet-Turcotte A et al.

Nature, 2013

23760478 (PubMed )
Supplement: NIHMS3939-supplement-2.pdf

Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase.

Lan L et al.

The Journal of Biological Chemistry, 2012

New developments in post-translational modifications and functions of histone H2A variants.

Thambirajah AA et al.

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire, 2009

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."