Associated Papers
A novel iPSC model of Bryant-Li-Bhoj neurodevelopmental/neurodegenerative syndrome demonstrates the role of histone H3.3 in chromatin dynamics, neuronal differentiation, and maturation.
Sangree AK et al.
Journal of Translational Medicine, 2026
Diffuse hemispheric glioma, H3 G34-mutant, a single centre experience and histopathological analysis.
Amer F et al.
Virchows Archiv : an International Journal of Pathology, 2025
A novel iPSC model of Bryant-Li-Bhoj neurodevelopmental/neurodegenerative syndrome demonstrates the role of histone H3.3 in chromatin dynamics, neuronal differentiation, and maturation.
Sangree AK et al.
Biorxiv : the Preprint Server for Biology, 2025
Coupling deep phenotypic quantification with next-generation phenotyping for 192 individuals with germline histonopathies.
Lubin EE et al.
Hgg Advances, 2025
Outcomes From a Contemporary Mono-Institutional Cohort of Histone-Mutant Diffuse Hemispheric Glioma: A Rare and Aggressive Pediatric-Type High-Grade Primary Brain Tumor.
Jeeva M et al.
Brain Tumor Research and Treatment, 2025
Expanded phenotypic spectrum of neurodevelopmental and neurodegenerative disorder Bryant-Li-Bhoj syndrome with 38 additional individuals.
Layo-Carris DE et al.
European Journal of Human Genetics : Ejhg, 2024
Aberrant DNA repair reveals a vulnerability in histone H3.3-mutant brain tumors.
Giacomini G et al.
Nucleic Acids Research, 2024
Histone mutations in cancer.
Espinoza Pereira KN et al.
Biochemical Society Transactions, 2023
Oncohistones and disrupted development in pediatric-type diffuse high-grade glioma.
Ocasio JK et al.
Cancer Metastasis Reviews, 2023
Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration.
Khazaei S et al.
Cell, 2023
H3.3-G34 mutations impair DNA repair and promote cGAS/STING-mediated immune responses in pediatric high-grade glioma models.
Haase S et al.
The Journal of Clinical Investigation, 2022
Histone H3.3 G34-mutant Diffuse Gliomas in Adults.
Wang L et al.
The American Journal of Surgical Pathology, 2022
Diagnostic Utility of Genetic and Immunohistochemical H3-3A Mutation Analysis in Giant Cell Tumour of Bone.
Wągrodzki M et al.
International Journal of Molecular Sciences, 2022
Chromatin mutations in pediatric high grade gliomas.
Voon HPJ et al.
Frontiers in Oncology, 2022
A common classification framework for histone sequence alterations in tumours: an expert consensus proposal.
Leske H et al.
The Journal of Pathology, 2021
Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants.
Bressan RB et al.
Cell Stem Cell, 2021
Alternative lengthening of telomeres in molecular subgroups of paediatric high-grade glioma.
Minasi S et al.
Child's Nervous System : Chns : Official Journal of the International Society for Pediatric Neurosurgery, 2021
Correlation Between Immunohistochemistry and Sequencing in H3G34-Mutant Gliomas.
Gianno F et al.
The American Journal of Surgical Pathology, 2021
Surprising phenotypic diversity of cancer-associated mutations of Gly 34 in the histone H3 tail.
Lowe BR et al.
Elife, 2021
Brain stem gliomas and current landscape.
Wummer B et al.
Journal of Neuro-oncology, 2021
Effects of H3.3G34V mutation on genomic H3K36 and H3K27 methylation patterns in isogenic pediatric glioma cells.
Huang TY et al.
Acta Neuropathologica Communications, 2020
Histone H3.3 beyond cancer: Germline mutations in Histone 3 Family 3A and 3B cause a previously unidentified neurodegenerative disorder in 46 patients.
Bryant L et al.
Science Advances, 2020
Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression.
Jain SU et al.
Proceedings of the National Academy of Sciences of the United States of America, 2020
The mechanistic GEMMs of oncogenic histones.
Lindroth AM et al.
Human Molecular Genetics, 2020
Base-resolution methylomes of gliomas bearing histone H3.3 mutations reveal a G34 mutant-specific signature shared with bone tumors.
Sangatsuda Y et al.
Scientific Reports, 2020
Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling.
Chen KY et al.
Communications Biology, 2020
Histone H3.3 mutation in giant cell tumor of bone: an update in pathology.
Yamamoto H et al.
Medical Molecular Morphology, 2020
Giant cell tumor of soft tissue of the breast: Case report with H3F3A mutation analysis and review of the literature.
Luangxay T et al.
Pathology, Research and Practice, 2020
Applications of molecular neuro-oncology - a review of diffuse glioma integrated diagnosis and emerging molecular entities.
Wood MD et al.
Diagnostic Pathology, 2019
The expanding landscape of 'oncohistone' mutations in human cancers.
Nacev BA et al.
Nature, 2019
Extraneural Metastases From a High-Grade Glioma (HGG) With an H3F3A G34R Mutation.
Jethanandani A et al.
Frontiers in Oncology, 2019
Rpp29 regulates histone H3.3 chromatin assembly through transcriptional mechanisms.
Shastrula PK et al.
The Journal of Biological Chemistry, 2018
Histone H3.3 G34 Mutations Alter Histone H3K36 and H3K27 Methylation In Cis.
Shi L et al.
Journal of Molecular Biology, 2018
Diagnostic utility of histone H3.3 G34W, G34R, and G34V mutant-specific antibodies for giant cell tumors of bone.
Yamamoto H et al.
Human Pathology, 2018
Highly recurrent H3F3A mutations with additional epigenetic regulator alterations in giant cell tumor of bone.
Ogura K et al.
Genes, Chromosomes & Cancer, 2017
The Histone Variant H3.3 in Transcriptional Regulation and Human Disease.
Shi L et al.
Journal of Molecular Biology, 2017
Evaluation of a novel antibody to define histone 3.3 G34R mutant brain tumours.
Haque F et al.
Acta Neuropathologica Communications, 2017
Detection of Histone H3 mutations in cerebrospinal fluid-derived tumor DNA from children with diffuse midline glioma.
Huang TY et al.
Acta Neuropathologica Communications, 2017
Mutation Analysis of H3F3A and H3F3B as a Diagnostic Tool for Giant Cell Tumor of Bone and Chondroblastoma.
Cleven AH et al.
The American Journal of Surgical Pathology, 2015
Isocitrate dehydrogenase mutations: new opportunities for translational research.
Keum YS et al.
Bmb Reports, 2015
Brainstem oligodendroglial tumors in children: two case reports and review of literatures.
Fukuoka K et al.
Child's Nervous System : Chns : Official Journal of the International Society for Pediatric Neurosurgery, 2015
Altered global histone-trimethylation code and H3F3A-ATRX mutation in pediatric GBM.
Pathak P et al.
Journal of Neuro-oncology, 2015
Pathology, Molecular Genetics, and Epigenetics of Diffuse Intrinsic Pontine Glioma.
Buczkowicz P et al.
Frontiers in Oncology, 2015
Epigenetic dysregulation: a novel pathway of oncogenesis in pediatric brain tumors.
Fontebasso AM et al.
Acta Neuropathologica, 2014
Unique genetic and epigenetic mechanisms driving paediatric diffuse high-grade glioma.
Jones C et al.
Nature Reviews. Cancer, 2014
Histone H3.3 is required to maintain replication fork progression after UV damage.
Frey A et al.
Current Biology : Cb, 2014