Associated Papers
A novel iPSC model of Bryant-Li-Bhoj neurodevelopmental/neurodegenerative syndrome demonstrates the role of histone H3.3 in chromatin dynamics, neuronal differentiation, and maturation.
Sangree AK et al.
Journal of Translational Medicine, 2026
Integrated high-resolution copy number and histomolecular analysis of diffuse hemispheric glioma, H3 G34-mutant reveals universal TP53 abnormalities.
Trejo-Lopez JA et al.
Brain Pathology (zurich, Switzerland), 2026
G34R cancer mutation alters the conformational ensemble and dynamics of the histone H3.3 tails.
Fuchs HA et al.
Nucleic Acids Research, 2026
Diffuse hemispheric glioma, H3 G34-mutant, a single centre experience and histopathological analysis.
Amer F et al.
Virchows Archiv : an International Journal of Pathology, 2025
A novel iPSC model of Bryant-Li-Bhoj neurodevelopmental/neurodegenerative syndrome demonstrates the role of histone H3.3 in chromatin dynamics, neuronal differentiation, and maturation.
Sangree AK et al.
Biorxiv : the Preprint Server for Biology, 2025
Implications of canonical histone H3.1 and histone variant H3.3 in cancer.
Wu P et al.
Open Biology, 2025
Outcomes From a Contemporary Mono-Institutional Cohort of Histone-Mutant Diffuse Hemispheric Glioma: A Rare and Aggressive Pediatric-Type High-Grade Primary Brain Tumor.
Jeeva M et al.
Brain Tumor Research and Treatment, 2025
G34R cancer mutation alters the conformational ensemble and dynamics of the histone H3.3 tails.
Fuchs HA et al.
Biorxiv : the Preprint Server for Biology, 2025
Next-Generation Sequencing in Oncology-A Guiding Compass for Targeted Therapy and Emerging Applications.
Galeș LN et al.
International Journal of Molecular Sciences, 2025
H3.3-G34R Mutation-Mediated Epigenetic Reprogramming Leads to Enhanced Efficacy of Immune Stimulatory Gene Therapy in Diffuse Hemispheric Gliomas.
Garcia-Fabiani MB et al.
Biorxiv : the Preprint Server for Biology, 2025
Multifunctional histone variants in genome function.
Wong LH et al.
Nature Reviews. Genetics, 2025
(B)On(e)-cohistones and the epigenetic alterations at the root of bone cancer.
Salomoni P et al.
Cell Death and Differentiation, 2025
Epigenetic reprogramming in pediatric gliomas: from molecular mechanisms to therapeutic implications.
Haase S et al.
Trends in Cancer, 2024
HIRA protects telomeres against R-loop-induced instability in ALT cancer cells.
Lynskey ML et al.
Cell Reports, 2024
Expanded phenotypic spectrum of neurodevelopmental and neurodegenerative disorder Bryant-Li-Bhoj syndrome with 38 additional individuals.
Layo-Carris DE et al.
European Journal of Human Genetics : Ejhg, 2024
Deposition of onco-histone H3.3-G34W leads to DNA repair deficiency and activates cGAS/STING-mediated immune responses.
Mancarella D et al.
International Journal of Cancer, 2024
H3F3A K27M Mutations Drives a Repressive Transcriptome by Modulating Chromatin Accessibility, Independent of H3K27me3 in Diffuse Midline Glioma.
Bhattarai S et al.
Biorxiv : the Preprint Server for Biology, 2024
Aberrant DNA repair reveals a vulnerability in histone H3.3-mutant brain tumors.
Giacomini G et al.
Nucleic Acids Research, 2024
Diffuse hemispheric glioma with H3-3B G34R mutation: Expanding the spectrum of histone H3 genes in diffuse hemispheric glioma, H3 G34-mutant.
Nazem A et al.
Journal of Neuropathology and Experimental Neurology, 2023
Pediatric glioma histone H3.3 K27M/G34R mutations drive abnormalities in PML nuclear bodies.
Voon HPJ et al.
Genome Biology, 2023
Oncohistones and disrupted development in pediatric-type diffuse high-grade glioma.
Ocasio JK et al.
Cancer Metastasis Reviews, 2023
Clinical, histopathological and molecular risk factors for recurrence of pilocytic astrocytomas: brainstem/spinal location, nestin expression and gain of 7q and 19 are associated with early tumor recurrence.
Tamura R et al.
Brain Tumor Pathology, 2023
The clinicopathological features and prognosis of multifocal high-grade gliomas in adults with H3F3A mutation.
Zhao Y et al.
Neurosciences (riyadh, Saudi Arabia), 2023
Dominant effects of the histone mutant H3-L61R on Spt16-gene interactions in budding yeast.
Pablo-Kaiser A et al.
Epigenetics, 2022
Adult type diffuse gliomas in the new 2021 WHO Classification.
Antonelli M et al.
Pathologica, 2022
H3.3-G34 mutations impair DNA repair and promote cGAS/STING-mediated immune responses in pediatric high-grade glioma models.
Haase S et al.
The Journal of Clinical Investigation, 2022
TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT.
de Nonneville A et al.
Embo Molecular Medicine, 2022
New twists to the ALTernative endings at telomeres.
Bhargava R et al.
Dna Repair, 2022
Diffuse Intrinsic Pontine Glioma: Molecular Landscape, Evolving Treatment Strategies and Emerging Clinical Trials.
Damodharan S et al.
Journal of Personalized Medicine, 2022
Histone H3.3 phosphorylation promotes heterochromatin formation by inhibiting H3K9/K36 histone demethylase.
Udugama M et al.
Nucleic Acids Research, 2022
The epigenetic-metabolic interplay in gliomagenesis.
Phasaludeen B et al.
Open Biology, 2022
Genetic and Epigenetic Inheritance at Telomeres.
Lister-Shimauchi EH et al.
Epigenomes, 2022
Histone H3.3 G34-mutant Diffuse Gliomas in Adults.
Wang L et al.
The American Journal of Surgical Pathology, 2022
Chromatin mutations in pediatric high grade gliomas.
Voon HPJ et al.
Frontiers in Oncology, 2022
Impact of Chromatin Dynamics and DNA Repair on Genomic Stability and Treatment Resistance in Pediatric High-Grade Gliomas.
Pinto L et al.
Cancers, 2021
The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma.
Bočkaj I et al.
Plos Genetics, 2021
Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma.
He C et al.
Nature Communications, 2021
A common classification framework for histone sequence alterations in tumours: an expert consensus proposal.
Leske H et al.
The Journal of Pathology, 2021
ALT Positivity in Human Cancers: Prevalence and Clinical Insights.
MacKenzie D et al.
Cancers, 2021
Mutations inhibiting KDM4B drive ALT activation in ATRX-mutated glioblastomas.
Udugama M et al.
Nature Communications, 2021
Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants.
Bressan RB et al.
Cell Stem Cell, 2021
Dissecting the impact of regional identity and the oncogenic role of human-specific NOTCH2NL in an hESC model of H3.3G34R-mutant glioma.
Funato K et al.
Cell Stem Cell, 2021
Alternative lengthening of telomeres in molecular subgroups of paediatric high-grade glioma.
Minasi S et al.
Child's Nervous System : Chns : Official Journal of the International Society for Pediatric Neurosurgery, 2021
Surprising phenotypic diversity of cancer-associated mutations of Gly 34 in the histone H3 tail.
Lowe BR et al.
Elife, 2021
Brain stem gliomas and current landscape.
Wummer B et al.
Journal of Neuro-oncology, 2021