Varaico: Literature-Extracted Genetic Variants

Gene:HDAC4
Variant:p.S246A
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HDAC4

NM_001378414.1:p.S246A

Associated Papers

Angiotensin II Mediates Cardiomyocyte Hypertrophy in Atrial Cardiomyopathy via Epigenetic Transcriptional Regulation.

Zheng L et al.

Computational and Mathematical Methods in Medicine, 2022

Regulation of p53 by the 14-3-3 protein interaction network: new opportunities for drug discovery in cancer.

Falcicchio M et al.

Cell Death Discovery, 2020

Unscheduled HDAC4 repressive activity in human fibroblasts triggers TP53-dependent senescence and favors cell transformation.

Paluvai H et al.

Molecular Oncology, 2018

Nucleus accumbens-associated protein-1 promotes glycolysis and survival of hypoxic tumor cells via the HDAC4-HIF-1α axis.

Zhang Y et al.

Oncogene, 2017

The tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases.

Walkinshaw DR et al.

The Journal of Biological Chemistry, 2013

Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia.

Li J et al.

Nature Medicine, 2012

Nuclear calcium/calmodulin-dependent protein kinase IIdelta preferentially transmits signals to histone deacetylase 4 in cardiac cells.

Little GH et al.

The Journal of Biological Chemistry, 2007

SMRTE inhibits MEF2C transcriptional activation by targeting HDAC4 and 5 to nuclear domains.

Wu X et al.

The Journal of Biological Chemistry, 2001

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."