Associated Papers
Cryo-EM structure of the Saccharomyces cerevisiae Rpd3L histone deacetylase complex.
Patel AB et al.
Nature Communications, 2023
Aromatic side-chain flips orchestrate the conformational sampling of functional loops in human histone deacetylase 8.
Shukla VK et al.
Chemical Science, 2021
Structural analysis of histone deacetylase 8 mutants associated with Cornelia de Lange Syndrome spectrum disorders.
Osko JD et al.
Journal of Structural Biology, 2021
Structural and Functional Influence of the Glycine-Rich Loop G302GGGY on the Catalytic Tyrosine of Histone Deacetylase 8.
Porter NJ et al.
Biochemistry, 2016
Structural aspects of HDAC8 mechanism and dysfunction in Cornelia de Lange syndrome spectrum disorders.
Deardorff MA et al.
Protein Science : a Publication of the Protein Society, 2016
General Base-General Acid Catalysis in Human Histone Deacetylase 8.
Gantt SM et al.
Biochemistry, 2016
Biochemical and structural characterization of HDAC8 mutants associated with Cornelia de Lange syndrome spectrum disorders.
Decroos C et al.
Biochemistry, 2015
Histone deacetylases: structural determinants of inhibitor selectivity.
Micelli C et al.
Drug Discovery Today, 2015
Compromised structure and function of HDAC8 mutants identified in Cornelia de Lange Syndrome spectrum disorders.
Decroos C et al.
Acs Chemical Biology, 2014
Histone deacetylase inhibitors suppress mutant p53 transcription via histone deacetylase 8.
Yan W et al.
Oncogene, 2013
HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle.
Deardorff MA et al.
Nature, 2012
Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.
Dowling DP et al.
Biochemistry, 2008
Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex.
Vannini A et al.
Embo Reports, 2007
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