Varaico: Literature-Extracted Genetic Variants

Gene:HERC2
Variant:p.C4762S
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HERC2

NM_004667.6:p.C4762S

Associated Papers

Mechanism of orphan subunit recognition during assembly quality control.

Yagita Y et al.

Cell, 2023

HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway altering the cellular response to oxidative stress.

Sala-Gaston J et al.

Cellular and Molecular Life Sciences : Cmls, 2022

How to Inactivate Human Ubiquitin E3 Ligases by Mutation.

Garcia-Barcena C et al.

Frontiers in Cell and Developmental Biology, 2020

Degradation of the deubiquitinating enzyme USP33 is mediated by p97 and the ubiquitin ligase HERC2.

Chan NC et al.

The Journal of Biological Chemistry, 2014

HERC2 is an E3 ligase that targets BRCA1 for degradation.

Wu W et al.

Cancer Research, 2010

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."