Associated Papers
USP30-mediated Deubiquitination of Hexokinase 2 controls the metabolic fate of glucose and tumor progression.
Haowei Z et al.
Cell Death & Disease, 2026
Hexokinase 2 is an RNA-binding protein that regulates mRNA translation independently of glycolysis and induces melanoma cell proliferation.
Dian AL et al.
Plos Biology, 2025
METTL3-mediated chromatin contacts promote stress granule phase separation through metabolic reprogramming during senescence.
Wang C et al.
Nature Communications, 2024
The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness.
Thomas GE et al.
Nature Cell Biology, 2022
Cellular acidosis triggers human MondoA transcriptional activity by driving mitochondrial ATP production.
Wilde BR et al.
Elife, 2019
The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation.
Nawaz MH et al.
Bioscience Reports, 2018
Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures.
Graham NA et al.
Molecular Systems Biology, 2017
Functional interaction between the N- and C-terminal halves of human hexokinase II.
Ardehali H et al.
The Journal of Biological Chemistry, 1999
Functional organization of mammalian hexokinase II. Retention of catalytic and regulatory functions in both the NH2- and COOH-terminal halves.
Ardehali H et al.
The Journal of Biological Chemistry, 1996
Linker residues regulate the activity and stability of hexokinase 2, a promising anticancer target.
Ferreira JC et al.
The Journal of Biological Chemistry, 0
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