Varaico: Literature-Extracted Genetic Variants

Gene:HMGCR
Variant:p.V174A
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HMGCR

NM_000859.3:p.V174A

Associated Papers

Recent advance in the pharmacogenomics of human Solute Carrier Transporters (SLCs) in drug disposition.

Zhou F et al.

Advanced Drug Delivery Reviews, 2017

Pharmacogenetic Foundations of Therapeutic Efficacy and Adverse Events of Statins.

Arrigoni E et al.

International Journal of Molecular Sciences, 2017

SLCO1B1 Gene Variations Among Tanzanians, Ethiopians, and Europeans: Relevance for African and Worldwide Precision Medicine.

Aklillu E et al.

Omics : a Journal of Integrative Biology, 2016

Association between SLCO1B1 -521T>C and -388A>G polymorphisms and risk of statin-induced adverse drug reactions: A meta-analysis.

Jiang J et al.

Springerplus, 2016

Frequencies of single-nucleotide polymorphisms and haplotypes of the SLCO1B1 gene in selected populations of the western balkans.

Grapci AD et al.

Balkan Journal of Medical Genetics : Bjmg, 2015

Genetic polymorphism of pharmacogenomic VIP variants in the Deng people from the Himalayas in Southeast Tibet.

Shi X et al.

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals, 2015

OATP1B1-related drug-drug and drug-gene interactions as potential risk factors for cerivastatin-induced rhabdomyolysis.

Tamraz B et al.

Pharmacogenetics and Genomics, 2013

Pharmacogenomics and adverse drug reactions: the case of statins.

Giorgi MA et al.

Expert Opinion on Pharmacotherapy, 2011

Common nonsynonymous substitutions in SLCO1B1 predispose to statin intolerance in routinely treated individuals with type 2 diabetes: a go-DARTS study.

Donnelly LA et al.

Clinical Pharmacology and Therapeutics, 2011

UGT1A1*6 polymorphism is most predictive of severe neutropenia induced by irinotecan in Japanese cancer patients.

Onoue M et al.

International Journal of Clinical Oncology, 2009

Comparison of SLCO1B1 sequence variability among German, Turkish, and African populations.

Mwinyi J et al.

European Journal of Clinical Pharmacology, 2008

Influence of OATP1B1 genotype on the pharmacokinetics of rosuvastatin in Koreans.

Choi JH et al.

Clinical Pharmacology and Therapeutics, 2008

OATP1B1 polymorphism is a major determinant of serum bilirubin level but not associated with rifampicin-mediated bilirubin elevation.

Zhang W et al.

Clinical and Experimental Pharmacology & Physiology, 2007

Organic anion transporting polypeptide-1B1 haplotypes in Chinese patients.

Xu LY et al.

Acta Pharmacologica Sinica, 2007

Hepatic OATP1B transporters and nuclear receptors PXR and CAR: interplay, regulation of drug disposition genes, and single nucleotide polymorphisms.

Meyer zu Schwabedissen HE et al.

Molecular Pharmaceutics, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."