Varaico: Literature-Extracted Genetic Variants

Gene:HNF4A
Variant:p.G60D
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HNF4A

NM_175914.5:p.G60D

Associated Papers

Assessment of CYP2D6 gene expression in liver tissue: Variability in CYP2D6 mRNA levels within genotype-predicted metabolizer phenotype groups.

Meaddough EL et al.

Chemico-biological Interactions, 2025

Trends in the Contribution of Genetic Susceptibility Loci to Hyperuricemia and Gout and Associated Novel Mechanisms.

Zhao J et al.

Frontiers in Cell and Developmental Biology, 2022

A Review of the Important Role of CYP2D6 in Pharmacogenomics.

Taylor C et al.

Genes, 2020

Transcriptional Regulation of CYP2D6 Expression.

Pan X et al.

Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2017

Krüppel-like factor 9 promotes hepatic cytochrome P450 2D6 expression during pregnancy in CYP2D6-humanized mice.

Koh KH et al.

Molecular Pharmacology, 2014

Pregnane X receptor and hepatocyte nuclear factor 4α polymorphisms are cooperatively associated with carbamazepine autoinduction.

Saruwatari J et al.

Pharmacogenetics and Genomics, 2014

Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation.

Zanger UM et al.

Pharmacology & Therapeutics, 2013

Effect of HNF4α genetic polymorphism G60D on the pharmacokinetics of CYP2D6 substrate tolterodine in healthy Korean individuals.

Jiang F et al.

Pharmacogenetics and Genomics, 2013

Genetic polymorphism of hepatocyte nuclear factor-4alpha influences human cytochrome P450 2D6 activity.

Lee SS et al.

Hepatology (baltimore, Md.), 2008

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."