Varaico: Literature-Extracted Genetic Variants

Gene:HRAS
Variant:p.D119N
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HRAS

NM_005343.4:p.D119N

Associated Papers

New insights into the classification of the RAC1 P29S hotspot mutation in melanoma as an oncogene.

Mirzaiebadizi A et al.

Cancer Gene Therapy, 2025

Functional Analysis of Rare RAS Variants of Unknown Significance.

Park S et al.

Cancer Research Communications, 2025

40970755 (PubMed )
Supplement: crc-25-0188_supplementary_table_s5_suppst5.xlsx › Supplementary_Table_S5

Somatic mutations in 3929 HPV positive cervical cells associated with infection outcome and HPV type.

Pinheiro M et al.

Nature Communications, 2024

39266536 (PubMed )
Supplement: 41467_2024_51713_MOESM5_ESM.xlsx › Data_2

Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants.

Khan I et al.

Cell Reports, 2022

ConVarT: a search engine for matching human genetic variants with variants from non-human species.

Pir MS et al.

Nucleic Acids Research, 2022

34718716 (PubMed )
Supplement: gkab939_supplemental_files.zip › Table_S5.xls › Sheet1

Comparative analysis of web-based programs for single amino acid substitutions in proteins.

Choudhury A et al.

Plos One, 2022

35507592 (PubMed )
Supplement: pone.0267084.s001.xlsx › HRAS

Structural bioinformatics enhances mechanistic interpretation of genomic variation, demonstrated through the analyses of 935 distinct RAS family mutations.

Tripathi S et al.

Bioinformatics (oxford, England), 2021

33226070 (PubMed )
Supplement: btaa972_supplementary_data.zip › RAS_Manuscript_RMarkdown.tar.gz › RAS_Manuscript1.Revised › RAS_Variants_Scores.xlsx › Sheet1

Mutation patterns in recurrent and/or metastatic oropharyngeal squamous cell carcinomas in relation to human papillomavirus status.

Reder H et al.

Cancer Medicine, 2021

33527763 (PubMed )
Supplement: CAM4-10-1347-s006.pdf

Comprehensive genomic profiling for patients with chemotherapy-naïve advanced cancer.

Kondo T et al.

Cancer Science, 2021

33007138 (PubMed )
Supplement: CAS-112-296-s002.xlsx › Sheet1

APOBEC Mutagenesis and Copy-Number Alterations Are Drivers of Proteogenomic Tumor Evolution and Heterogeneity in Metastatic Thoracic Tumors.

Roper N et al.

Cell Reports, 2019

30840888 (PubMed )
Supplement: NIHMS1523294-supplement-6.xlsx › RA006

Diverging gain-of-function mechanisms of two novel KRAS mutations associated with Noonan and cardio-facio-cutaneous syndromes.

Cirstea IC et al.

Human Molecular Genetics, 2013

An unusual H-Ras mutant isolated from a human multiple myeloma line leads to transformation and factor-independent cell growth.

Crowder C et al.

Oncogene, 2003

Biochemical and biological consequences of changing the specificity of p21ras from guanosine to xanthosine nucleotides.

Schmidt G et al.

Oncogene, 1996

Switching nucleotide specificity of Ha-Ras p21 by a single amino acid substitution at aspartate 119.

Zhong JM et al.

The Journal of Biological Chemistry, 1995

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."