Associated Papers
Beyond structural bioinformatics for genomics with dynamics characterization of an expanded KRAS mutational landscape.
Ratnasinghe BD et al.
Computational and Structural Biotechnology Journal, 2023
Delineating the RAS Conformational Landscape.
Parker MI et al.
Cancer Research, 2022
The path to the clinic: a comprehensive review on direct KRASG12C inhibitors.
Kwan AK et al.
Journal of Experimental & Clinical Cancer Research : Cr, 2022
Selective and noncovalent targeting of RAS mutants for inhibition and degradation.
Teng KW et al.
Nature Communications, 2021
NMR in integrated biophysical drug discovery for RAS: past, present, and future.
Marshall CB et al.
Journal of Biomolecular Nmr, 2020
Clinical Characteristics and Outcomes of Non-small Cell Lung Cancer Patients with HER2 Alterations in Korea.
Lee K et al.
Cancer Research and Treatment, 2020
Structures of N-terminally processed KRAS provide insight into the role of N-acetylation.
Dharmaiah S et al.
Scientific Reports, 2019
KRAS Switch Mutants D33E and A59G Crystallize in the State 1 Conformation.
Lu J et al.
Biochemistry, 2018
Attenuated phenotype of Costello syndrome and early death in a patient with an HRAS mutation (c.179G>T; p.Gly60Val) affecting signalling dynamics.
Gripp KW et al.
Clinical Genetics, 2017
An attenuated phenotype of Costello syndrome in three unrelated individuals with a HRAS c.179G>A (p.Gly60Asp) mutation correlates with uncommon functional consequences.
Gripp KW et al.
American Journal of Medical Genetics. Part A, 2015
Rasd1 interacts with Ear2 (Nr2f6) to regulate renin transcription.
Tan JJ et al.
Bmc Molecular Biology, 2011
Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders.
Gremer L et al.
Human Mutation, 2011
Slow conformational dynamics of the guanine nucleotide-binding protein Ras complexed with the GTP analogue GTPgammaS.
Spoerner M et al.
The Febs Journal, 2007
Noonan syndrome and related disorders: dysregulated RAS-mitogen activated protein kinase signal transduction.
Gelb BD et al.
Human Molecular Genetics, 2006
A novel membrane-anchored Rab5 interacting protein required for homotypic endosome fusion.
Hoffenberg S et al.
The Journal of Biological Chemistry, 2000
Mutational analysis of Raf-1 cysteine rich domain: requirement for a cluster of basic aminoacids for interaction with phosphatidylserine.
Improta-Brears T et al.
Molecular and Cellular Biochemistry, 1999
Ras interaction with two distinct binding domains in Raf-1 may be required for Ras transformation.
Drugan JK et al.
The Journal of Biological Chemistry, 1996