Associated Papers
Conformational States of the GDP- and GTP-Bound HRAS Affected by A59E and K117R: An Exploration from Gaussian Accelerated Molecular Dynamics.
Yu Z et al.
Molecules (basel, Switzerland), 2024
Delineating the RAS Conformational Landscape.
Parker MI et al.
Cancer Research, 2022
The path to the clinic: a comprehensive review on direct KRASG12C inhibitors.
Kwan AK et al.
Journal of Experimental & Clinical Cancer Research : Cr, 2022
Comparative analysis of web-based programs for single amino acid substitutions in proteins.
Choudhury A et al.
Plos One, 2022
Selective and noncovalent targeting of RAS mutants for inhibition and degradation.
Teng KW et al.
Nature Communications, 2021
Natural Products Attenuating Biosynthesis, Processing, and Activity of Ras Oncoproteins: State of the Art and Future Perspectives.
Tisi R et al.
Biomolecules, 2020
NMR in integrated biophysical drug discovery for RAS: past, present, and future.
Marshall CB et al.
Journal of Biomolecular Nmr, 2020
The Ras-ERK signaling pathway regulates acetylated activating transcription factor 2 via p300 in pancreatic cancer cells.
Li M et al.
Annals of Translational Medicine, 2020
Structures of N-terminally processed KRAS provide insight into the role of N-acetylation.
Dharmaiah S et al.
Scientific Reports, 2019
Pharmacological targeting of RAS: Recent success with direct inhibitors.
O'Bryan JP
Pharmacological Research, 2019
KRAS Switch Mutants D33E and A59G Crystallize in the State 1 Conformation.
Lu J et al.
Biochemistry, 2018
The RAS-Effector Interaction as a Drug Target.
Keeton AB et al.
Cancer Research, 2017
The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding Regions.
Nakhaeizadeh H et al.
Plos One, 2016
Transcriptional signatures of Ral GTPase are associated with aggressive clinicopathologic characteristics in human cancer.
Smith SC et al.
Cancer Research, 2012
Duplication of Glu37 in the switch I region of HRAS impairs effector/GAP binding and underlies Costello syndrome by promoting enhanced growth factor-dependent MAPK and AKT activation.
Gremer L et al.
Human Molecular Genetics, 2010
Mitofusin-2 regulates mitochondrial and endoplasmic reticulum morphology and tethering: the role of Ras.
de Brito OM et al.
Mitochondrion, 2009
Slow conformational dynamics of the guanine nucleotide-binding protein Ras complexed with the GTP analogue GTPgammaS.
Spoerner M et al.
The Febs Journal, 2007
Synergistic activation of the murine gastrin promoter by oncogenic Ras and beta-catenin involves SMAD recruitment.
Chakladar A et al.
Biochemical and Biophysical Research Communications, 2005
Conformational states of Ras complexed with the GTP analogue GppNHp or GppCH2p: implications for the interaction with effector proteins.
Spoerner M et al.
Biochemistry, 2005
Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells.
Pattingre S et al.
The Journal of Biological Chemistry, 2003
Structural basis for the interaction of Ras with RalGDS.
Huang L et al.
Nature Structural Biology, 1998
Differential structural requirements for interaction of Ras protein with its distinct downstream effectors.
Akasaka K et al.
The Journal of Biological Chemistry, 1996
Dissecting the roles of Raf- and PI3K-signalling pathways in melanoma formation and progression in a zebrafish model.
Michailidou C et al.
Disease Models & Mechanisms, 0