Varaico: Literature-Extracted Genetic Variants

Gene:HSPB3
Variant:p.K68Q
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HSPB3

NM_006308.3:p.K68Q

Associated Papers

Association of lncRNA PRNCR1 polymorphisms with cancer susceptibility: a meta-analysis of the current literature.

Du P et al.

Journal of Genetics, 2021

Relationship between growth velocity and change of levels of insulin-like growth factor-1, insulin-like growth factor binding protein-3 and, IGFBP-3 promoter polymorphism during GnRH agonist treatment.

Park JH et al.

Annals of Pediatric Endocrinology & Metabolism, 2020

Association between acromegaly and a single nucleotide polymorphism (rs2854744) in the IGFBP3 gene.

Gao M et al.

Bmc Medical Genetics, 2018

Influence of The -202 A/C insulin-like growth factor-binding protein-3 promoter polymorphism on individual variation in height in Korean girls.

Yi MJ et al.

Annals of Pediatric Endocrinology & Metabolism, 2017

Genotypic and phenotypic predictors of inflammation in patients with chronic kidney disease.

Luttropp K et al.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 2016

27190335 (PubMed )
Supplement: gfw066_Supplementary_Data.zip › gfw066supp_table1.docx

Genetic variants in insulin-like growth factor binding protein-3 are associated with prostate cancer susceptibility in Eastern Chinese Han men.

Zhang G et al.

Oncotargets and Therapy, 2016

Polymorphism in IGFBP3 gene is associated with prostate cancer risk: an updated meta-analysis.

Qie Y et al.

Oncotargets and Therapy, 2016

Influence of growth hormone receptor (GHR) exon 3 and -202A/C IGFBP-3 genetic polymorphisms on clinical and biochemical features and therapeutic outcome of patients with acromegaly.

Jallad RS et al.

Pituitary, 2015

Polymorphisms of insulin-like growth factor binding protein-3 as a predictor for risk and patient survival in esophageal squamous cell carcinoma.

Zhao L et al.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 2015

IGFBP-3 A-202C and C2133G polymorphisms and colorectal cancer risk: a meta-analysis of case-control studies.

Xu J et al.

Genetics and Molecular Research : Gmr, 2015

Impact of the IGFBP3 A-202C polymorphism on susceptibility and clinicopathologic features of breast cancer.

Ma X et al.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 2015

Systematic review and meta-analysis of candidate gene association studies of lower urinary tract symptoms in men.

Cartwright R et al.

European Urology, 2014

Genetic predictors of long-term response to growth hormone (GH) therapy in children with GH deficiency and Turner syndrome: the influence of a SOCS2 polymorphism.

Braz AF et al.

The Journal of Clinical Endocrinology and Metabolism, 2014

IGF1(CA)19 and IGFBP-3-202A/C gene polymorphism and cancer risk: a meta-analysis.

Quan H et al.

Cell Biochemistry and Biophysics, 2014

IGFBP-3 promoter polymorphism -202A>C (rs2854774) contributes to prostate cancer risk: evidence based on 9,482 subjects.

Ding Q et al.

Urologia Internationalis, 2014

Maximal oxygen uptake is associated with allele -202 A of insulin-like growth factor binding protein-3 (IGFBP3) promoter polymorphism and (CA)n tandem repeats of insulin-like growth factor IGF1 in Caucasians from Poland.

Gronek P et al.

Acta Biochimica Polonica, 2014

The influence of promoter -202 A/C polymorphism (rs2854744) of the IGFBP-3 gene on erectile dysfunction risk and serum levels of IGF-I and IGFBP-3.

Safarinejad MR et al.

The Journal of Urology, 2013

Meta-analysis of the association between insulin-like growth factor binding protein 3 genetic polymorphisms and colorectal cancer susceptibility.

Xiang H et al.

Plos One, 2013

Growth hormone pharmacogenetics: the interactive effect of a microsatellite in the IGF1 promoter region with the GHR-exon 3 and -202 A/C IGFBP3 variants on treatment outcomes of children with severe GH deficiency.

Costalonga EF et al.

The Pharmacogenomics Journal, 2012

Functional polymorphisms in the insulin-like binding protein-3 gene may modulate susceptibility to differentiated thyroid carcinoma in Caucasian Americans.

Xu L et al.

Molecular Carcinogenesis, 2012

Association of the (CA)n repeat polymorphism of insulin-like growth factor-I and -202 A/C IGF-binding protein-3 promoter polymorphism with adult height in patients with severe growth hormone deficiency.

Miletta MC et al.

Clinical Endocrinology, 2012

Performance of an adipokine pathway-based multilocus genetic risk score for prostate cancer risk prediction.

Ribeiro RJ et al.

Plos One, 2012

The association between bladder cancer and a single nucleotide polymorphism (rs2854744) in the insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) gene.

Safarinejad MR et al.

Archives of Toxicology, 2011

Insulin-like growth factor binding protein-3 (IGFBP-3) gene variants are associated with renal cell carcinoma.

Safarinejad MR

Bju International, 2011

Relationship of insulin-like growth factor (IGF) binding protein-3 (IGFBP-3) gene polymorphism with the susceptibility to development of prostate cancer and influence on serum levels of IGF-I, and IGFBP-3.

Safarinejad MR et al.

Growth Hormone & Igf Research : Official Journal of the Growth Hormone Research Society and the International Igf Research Society, 2011

Association between insulin-like growth factor binding protein-3 promoter polymorphism of -1590 C>A and lung cancer susceptibility in a Chinese Han population.

Dai X et al.

Genetic Testing and Molecular Biomarkers, 2011

IGF(CA)19 and IGFBP-3-202A/C gene polymorphism in patients with acromegaly.

Akin F et al.

Growth Hormone & Igf Research : Official Journal of the Growth Hormone Research Society and the International Igf Research Society, 2010

Insulin-like growth factor axis gene polymorphisms and clinical outcomes in pancreatic cancer.

Dong X et al.

Gastroenterology, 2010

Influence of IGFBP3 gene polymorphisms on IGFBP3 serum levels and the risk of prostate cancer in low-risk Korean men.

Park K et al.

Urology, 2010

Phenotypes and genotypes of insulin-like growth factor 1, IGF-binding protein-3 and cancer risk: evidence from 96 studies.

Chen W et al.

European Journal of Human Genetics : Ejhg, 2009

Associations of insulin-like growth factor binding protein-3 gene polymorphisms with IGF-I activity and lipid parameters in adolescents.

Mong JL et al.

International Journal of Obesity (2005), 2009

Predictors of variation in serum IGF1 and IGFBP3 levels in healthy African American and white men.

Hoyo C et al.

Journal of the National Medical Association, 2009

IGF-I and IGFBP-3 polymorphisms in relation to circulating levels among African American and Caucasian women.

D'Aloisio AA et al.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 2009

The -202 A allele of insulin-like growth factor binding protein-3 (IGFBP3) promoter polymorphism is associated with higher IGFBP-3 serum levels and better growth response to growth hormone treatment in patients with severe growth hormone deficiency.

Costalonga EF et al.

The Journal of Clinical Endocrinology and Metabolism, 2009

Insulin-like growth factor-I gene and insulin-like growth factor binding protein-3 polymorphism in patients with thyroid dysfunction.

Kursunluoglu R et al.

Archives of Medical Research, 2009

Single nucleotide polymorphisms of IGFBP-3 gene and lung cancer risk in a Korean population.

Han SG et al.

Lung Cancer (amsterdam, Netherlands), 2008

Absence of association between SNPs in the promoter region of the insulin-like growth factor 1 (IGF-1) gene and longevity in the Han Chinese population.

Xie L et al.

Experimental Gerontology, 2008

Genetic polymorphisms involved in insulin-like growth factor (IGF) pathway in relation to mammographic breast density and IGF levels.

Diorio C et al.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 2008

Identification of upstream stimulatory factor binding sites in the human IGFBP3 promoter and potential implication of adjacent single-nucleotide polymorphisms and responsiveness to insulin.

Paquette J et al.

Endocrinology, 2007

IGF-1 and IGFBP-3 gene variants influence on serum levels and prostate cancer risk in African-Americans.

Hernandez W et al.

Carcinogenesis, 2007

Grade-specific prostate cancer associations of IGF1 (CA)19 repeats and IGFBP3-202A/C in blacks and whites.

Hoyo C et al.

Journal of the National Medical Association, 2007

Polymorphisms of genes coding for insulin-like growth factor 1 and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC study.

Canzian F et al.

British Journal of Cancer, 2006

Promoter -202 A/C polymorphism of insulin-like growth factor binding protein-3 gene and non-small cell lung cancer risk.

Moon JW et al.

International Journal of Cancer, 2006

IGF-I and IGFBP-3 polymorphisms and risk of prostate cancer.

Friedrichsen DM et al.

The Prostate, 2005

IGF1 (CA)19 repeat and IGFBP3 -202 A/C genotypes and the risk of prostate cancer in Black and White men.

Schildkraut JM et al.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 2005

Insulin-like growth factor-binding protein-3 gene -202 A/C polymorphism is correlated with advanced disease status in prostate cancer.

Wang L et al.

Cancer Research, 2003

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