Varaico: Literature-Extracted Genetic Variants

Gene:HTR2A
Variant:p.H452Y
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HTR2A

NM_000621.5:p.H452Y

Associated Papers

The role of 5-hydroxytryptamine receptor 2A (HTR2A) gene polymorphisms in treatment-resistant obsessive-compulsive disorder: a comparative study with other treatment-resistant mental disorders.

Del Casale A et al.

Bmc Psychiatry, 2025

Dopaminergic and serotonergic genetic variants predict actions and expectations of cooperation and punishment.

Marcos-Prieto P et al.

Scientific Reports, 2025

Mood disorders and 5-HTR2A genetic variants - the moderator effect of inflammation on expression of affective polarity phenotype.

Pantovic-Stefanovic M et al.

Bmc Psychiatry, 2024

Influence of Genetic Polymorphisms on Cognitive Function According to Dietary Exposure to Bisphenols in a Sample of Spanish Schoolchildren.

Ramírez V et al.

Nutrients, 2024

Association of GABRG3, GABRB3, HTR2A gene variants with autism spectrum disorder.

Coskunpinar EM et al.

Gene, 2023

The Progress and Pitfalls of Pharmacogenetics-Based Precision Medicine in Schizophrenia Spectrum Disorders: A Systematic Review and Meta-Analysis.

Teng Y et al.

Journal of Personalized Medicine, 2023

36983653 (PubMed )
Supplement: jpm-13-00471-s001.zip › Supplementary_Table_S2.xlsx › Table_S2

Antipsychotic drug-aripiprazole against schizophrenia, its therapeutic and metabolic effects associated with gene polymorphisms.

Stelmach A et al.

Pharmacological Reports : Pr, 2023

Translational Genomic Research: The Association between Genetic Profiles and Cognitive Functioning or Cardiac Function Among Breast Cancer Survivors Completing Chemotherapy.

Park JY et al.

Biological Research for Nursing, 2022

5-HT2A SNPs Alter the Pharmacological Signaling of Potentially Therapeutic Psychedelics.

Schmitz GP et al.

Acs Chemical Neuroscience, 2022

Candidate Genes and Pathways Associated with Gilles de la Tourette Syndrome-Where Are We?

Levy AM et al.

Genes, 2021

34573303 (PubMed )
Supplement: genes-12-01321-s001.zip › genes-1240846-supplementary.pdf

An Example of Personalized Treatment in HR+ HER2+ Long Survivor Breast Cancer Patient (Case Report).

Panebianco M et al.

Current Oncology (toronto, Ont.), 2021

34070464 (PubMed )
Supplement: curroncol-28-00184-s001.zip › curroncol-1167217-SI.pdf

Associations between the 1438A/G, 102T/C, and rs7997012G/A polymorphisms of HTR2A and the safety and efficacy of antidepressants in depression: a meta-analysis.

Wan YS et al.

The Pharmacogenomics Journal, 2021

His452Tyr polymorphism in the human 5-HT2A receptor affects clozapine-induced signaling networks revealed by quantitative phosphoproteomics.

Martín-Guerrero SM et al.

Biochemical Pharmacology, 2021

Metabolic Effects of Aripiprazole and Olanzapine Multiple-Dose Treatment in a Randomised Crossover Clinical Trial in Healthy Volunteers: Association with Pharmacogenetics.

Koller D et al.

Advances in Therapy, 2021

Drug-Drug Interactions and Pharmacogenomic Evaluation in Colorectal Cancer Patients: The New Drug-PIN® System Comprehensive Approach.

Roberto M et al.

Pharmaceuticals (basel, Switzerland), 2021

33467633 (PubMed )
Supplement: pharmaceuticals-14-00067-s001.pdf

Common HTR2A variants and 5-HTTLPR are not associated with human in vivo serotonin 2A receptor levels.

Spies M et al.

Human Brain Mapping, 2020

The genetics of drug-related movement disorders, an umbrella review of meta-analyses.

van der Burg NC et al.

Molecular Psychiatry, 2020

The effects of aripiprazole and olanzapine on pupillary light reflex and its relationship with pharmacogenetics in a randomized multiple-dose trial.

Koller D et al.

British Journal of Clinical Pharmacology, 2020

Coevolution of Residues Provides Evidence of a Functional Heterodimer of 5-HT2AR and 5-HT2CR Involving Both Intracellular and Extracellular Domains.

Fongang B et al.

Neuroscience, 2019

Association between serotonin 2A receptor genetic variations, stressful life events and suicide.

Ghasemi A et al.

Gene, 2018

Association of Serotonin Receptors with Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-analysis.

Hou YW et al.

Current Medical Science, 2018

Sperm count and motility are quantitatively affected by functional polymorphisms of HTR2A, MAOA and SLC18A.

Cortés-Rodriguez M et al.

Reproductive Biomedicine Online, 2018

The promoter polymorphisms in HTR2A gene associated with schizophrenia in Chinese of Han ethnicity.

Sun Q et al.

Psychiatry Research, 2018

Novel human genome variants associated with alcohol use disorders identified in a Lithuanian cohort.

Baronas K et al.

Acta Medica Lituanic, 2018

Clozapine Pharmacogenetic Studies in Schizophrenia: Efficacy and Agranulocytosis.

Numata S et al.

Frontiers in Pharmacology, 2018

mRNA Expression and DNA Methylation Analysis of Serotonin Receptor 2A (HTR2A) in the Human Schizophrenic Brain.

Cheah SY et al.

Genes, 2017

Impact of genetic variation in the 5-HT transporter and receptor on platelet function in patients with stable CAD taking aspirin.

Bajrangee A et al.

Thrombosis Research, 2016

Pharmacogenetic tests for antipsychotic medications: clinical implications and considerations.

Eum S et al.

Dialogues in Clinical Neuroscience, 2016

Association of Polymorphisms within the Serotonin Receptor Genes 5-HTR1A, 5-HTR1B, 5-HTR2A and 5-HTR2C and Migraine Susceptibility in a Turkish Population.

Yücel Y et al.

Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology, 2016

A functional 5HT2A receptor polymorphism (His452Tyr) and memory performances in Alzheimer's disease.

Guglielmi V et al.

The International Journal of Neuroscience, 2016

Pharmacogenetics of clozapine response and induced weight gain: A comprehensive review and meta-analysis.

Gressier F et al.

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, 2016

A review of genetic alterations in the serotonin pathway and their correlation with psychotic diseases and response to atypical antipsychotics.

Baou M et al.

Schizophrenia Research, 2016

Effect of polymorphisms of three genes mediating monoamine signalling on brain morphometry in schizophrenia and healthy subjects.

Vijayakumari AA et al.

Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology, 2015

Association of 5-HT2A receptor gene polymorphisms with gastrointestinal disorders in Egyptian children with autistic disorder.

Abdelrahman HM et al.

Research in Developmental Disabilities, 2015

Polymorphism in the serotonin receptor 2a (HTR2A) gene as possible predisposal factor for aggressive traits.

Banlaki Z et al.

Plos One, 2015

Converging translational evidence for the involvement of the serotonin 2A receptor gene in major depressive disorder.

Petit AC et al.

Progress in Neuro-psychopharmacology & Biological Psychiatry, 2014

Family-based clinical associations and functional characterization of the serotonin 2A receptor gene (HTR2A) in autism spectrum disorder.

Smith RM et al.

Autism Research : Official Journal of the International Society for Autism Research, 2014

Association of the T102C polymorphism in the HTR2A gene with major depressive disorder, bipolar disorder, and schizophrenia.

Tan J et al.

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics, 2014

Serotonin 2A receptor gene (HTR2A) regulatory variants: possible association with severity of depression symptoms in children with autism spectrum disorder.

Gadow KD et al.

Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology, 2014

Association of the HTR2A gene with alcohol and heroin abuse.

Cao J et al.

Human Genetics, 2014

Genetics of borderline personality disorder: systematic review and proposal of an integrative model.

Amad A et al.

Neuroscience and Biobehavioral Reviews, 2014

Genes in the serotonin pathway are associated with bipolar affective disorder in a Han Chinese population.

Xiang B et al.

Neuroscience Bulletin, 2014

Clinical significance of pharmacogenomic studies in tardive dyskinesia associated with patients with psychiatric disorders.

Chang FC et al.

Pharmacogenomics and Personalized Medicine, 2014

True but not false memories are associated with the HTR2A gene.

Zhu B et al.

Neurobiology of Learning and Memory, 2013

A pilot study evaluating genetic and environmental factors for postpartum depression.

El-Ibiary SY et al.

Innovations in Clinical Neuroscience, 2013

Family-based study of HTR2A in suicide attempts: observed gene, gene × environment and parent-of-origin associations.

Ben-Efraim YJ et al.

Molecular Psychiatry, 2013

Genetic variation and the risk of haloperidol-related parkinsonism in elderly patients: a candidate gene approach.

Knol W et al.

Journal of Clinical Psychopharmacology, 2013

Association of common genetic variants with risperidone adverse events in a Spanish schizophrenic population.

Almoguera B et al.

The Pharmacogenomics Journal, 2013

Attenuated PLD1 association and signalling at the H452Y polymorphic form of the 5-HT(2A) receptor.

Barclay Z et al.

Cellular Signalling, 2013

Multiple regulatory variants modulate expression of 5-hydroxytryptamine 2A receptors in human cortex.

Smith RM et al.

Biological Psychiatry, 2013

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."