Varaico: Literature-Extracted Genetic Variants

Gene:HTR2C
Variant:p.T253T
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HTR2C

NM_000868.4:p.T253T

Associated Papers

Investigation of leptin and leptin receptor gene polymorphisms in schizophrenia: further support for an association with attempted suicide.

Aytac HM et al.

Acta Neuropsychiatrica, 2026

The impact of genetic variability on Alzheimer's therapies: obstacles for pharmacogenetic progress.

Cacabelos R et al.

Expert Opinion on Drug Metabolism & Toxicology, 2025

Phenotype driven molecular genetic test recommendation for diagnosing pediatric rare disorders.

Chen F et al.

Npj Digital Medicine, 2024

39572625 (PubMed )
Supplement: 41746_2024_1331_MOESM2_ESM.xlsx › Supplementary_Data_6

The polymorphisms of candidate pharmacokinetic and pharmacodynamic genes and their pharmacogenetic impacts on the effectiveness of risperidone maintenance therapy among Saudi children with autism.

Shilbayeh SAR et al.

European Journal of Clinical Pharmacology, 2024

The Progress and Pitfalls of Pharmacogenetics-Based Precision Medicine in Schizophrenia Spectrum Disorders: A Systematic Review and Meta-Analysis.

Teng Y et al.

Journal of Personalized Medicine, 2023

Pharmacogenetics of anxiety and depression in Alzheimer's disease.

Cacabelos R et al.

Pharmacogenomics, 2023

Analytical validation of GenoPharm a clinical genotyping open array panel of 46 pharmacogenes inclusive of variants unique to people of African ancestry.

Kanji CR et al.

Plos One, 2023

Serotonin Receptor Gene Polymorphisms Are Associated with Cerebrospinal Fluid, Genetic, and Neuropsychological Biomarkers of Alzheimer's Disease.

Babić Leko M et al.

Biomedicines, 2022

The pharmacogenetics of treatment with olanzapine.

Zubiaur P et al.

Pharmacogenomics, 2021

Effect of 5-HT2C receptor gene polymorphism (HTR2C-759C/T) on metabolic adverse effects in Thai psychiatric patients treated with risperidone.

Vanwong N et al.

Pharmacoepidemiology and Drug Safety, 2021

Metabolic Effects of Aripiprazole and Olanzapine Multiple-Dose Treatment in a Randomised Crossover Clinical Trial in Healthy Volunteers: Association with Pharmacogenetics.

Koller D et al.

Advances in Therapy, 2021

Development and Analytical Validation of a 29 Gene Clinical Pharmacogenetic Genotyping Panel: Multi-Ethnic Allele and Copy Number Variant Detection.

Scott SA et al.

Clinical and Translational Science, 2021

Genetic Polymorphisms Associated With the Pharmacokinetics, Pharmacodynamics and Adverse Effects of Olanzapine, Aripiprazole and Risperidone.

Soria-Chacartegui P et al.

Frontiers in Pharmacology, 2021

Pharmacogenomics Factors Influencing the Effect of Risperidone on Prolactin Levels in Thai Pediatric Patients With Autism Spectrum Disorder.

Hongkaew Y et al.

Frontiers in Pharmacology, 2021

The effects of aripiprazole and olanzapine on pupillary light reflex and its relationship with pharmacogenetics in a randomized multiple-dose trial.

Koller D et al.

British Journal of Clinical Pharmacology, 2020

Pharmacodynamic Gene Testing in Prader-Willi Syndrome.

Forster J et al.

Frontiers in Genetics, 2020

Dopamine (DRD2) and Serotonin (HTR2A, 2C) Receptor Gene Polymorphisms do not influence early response to Risperidone in South Indian Patients with Schizophrenia.

Alladi CG et al.

Fundamental & Clinical Pharmacology, 2019

CALCA and TRPV1 genes polymorphisms are related to a good outcome in female chronic migraine patients treated with OnabotulinumtoxinA.

Moreno-Mayordomo R et al.

The Journal of Headache and Pain, 2019

Association of Serotonin2c Receptor Polymorphisms With Antipsychotic Drug Response in Schizophrenia.

Li J et al.

Frontiers in Psychiatry, 2019

Progress in Genetic Polymorphisms Related to Lipid Disturbances Induced by Atypical Antipsychotic Drugs.

Li N et al.

Frontiers in Pharmacology, 2019

Effects of aripiprazole on pupillometric parameters related to pharmacokinetics and pharmacogenetics after single oral administration to healthy subjects.

Koller D et al.

Journal of Psychopharmacology (oxford, England), 2018

The role of genetics and genomics in clinical psychiatry.

Hoehe MR et al.

Dialogues in Clinical Neuroscience, 2018

Pharmacogenetics of Risperidone-Induced Insulin Resistance in Children and Adolescents with Autism Spectrum Disorder.

Sukasem C et al.

Basic & Clinical Pharmacology & Toxicology, 2018

Effect of Polymorphisms on the Pharmacokinetics, Pharmacodynamics and Safety of Sertraline in Healthy Volunteers.

Saiz-Rodríguez M et al.

Basic & Clinical Pharmacology & Toxicology, 2018

Genetic polymorphisms of HTR2C, LEP and LEPR on metabolic syndromes in patients treated with atypical antipsychotic drugs.

Puangpetch A et al.

The Journal of Pharmacy and Pharmacology, 2018

Pharmacogenetics.

Bishop JR

Handbook of Clinical Neurology, 2018

Drug-naive patients with schizophrenia have metabolic disorders that are not associated with polymorphisms in the LEP (-2548G/A) and 5-HTR2C (-759C/T) genes.

Chen J et al.

International Journal of Clinical and Experimental Pathology, 2018

Identification of genetic correlates of response to Risperidone: Findings of a multicentric schizophrenia study from India.

Kaur G et al.

Asian Journal of Psychiatry, 2017

Enhanced Expression of Serotonin Receptor 5-Hydroxytryptamine 2C is Associated with Increased Feather Damage in Dongxiang Blue-Shelled Layers.

Yao J et al.

Behavior Genetics, 2017

Genetic Determinants of Clozapine-Induced Metabolic Side Effects.

Vasudev K et al.

Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie, 2017

Pharmacogenetic tests for antipsychotic medications: clinical implications and considerations.

Eum S et al.

Dialogues in Clinical Neuroscience, 2016

Association of Polymorphisms within the Serotonin Receptor Genes 5-HTR1A, 5-HTR1B, 5-HTR2A and 5-HTR2C and Migraine Susceptibility in a Turkish Population.

Yücel Y et al.

Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology, 2016

Pharmacogenetics of clozapine response and induced weight gain: A comprehensive review and meta-analysis.

Gressier F et al.

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, 2016

A review of genetic alterations in the serotonin pathway and their correlation with psychotic diseases and response to atypical antipsychotics.

Baou M et al.

Schizophrenia Research, 2016

Association between the HTR2C rs1414334 C/G gene polymorphism and the development of the metabolic syndrome in patients treated with atypical antipsychotics.

Rico-Gomis JM et al.

Peerj, 2016

-759C÷T polymorphism of the HTR2C gene is not correlated with atypical antipsychotics-induced weight gain, among Romanian psychotic patients.

Grădinaru RC et al.

Romanian Journal of Morphology and Embryology = Revue Roumaine De Morphologie Et Embryologie, 2016

SLC6A14 and 5-HTR2C polymorphisms are associated with food intake and nutritional status in children.

Miranda RC et al.

Clinical Biochemistry, 2015

The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with increased body mass index and insulin resistance measures in bipolar disorder and schizophrenia.

Bonaccorso S et al.

Bipolar Disorders, 2015

A double amino-acid change in the HLA-A peptide-binding groove is associated with response to psychotropic treatment in patients with schizophrenia.

Le Clerc S et al.

Translational Psychiatry, 2015

Methylenetetrahydrofolate reductase gene variants and antipsychotic-induced weight gain and metabolic disturbances.

Kao AC et al.

Journal of Psychiatric Research, 2014

Pharmacogenetics of second-generation antipsychotics.

Brennan MD

Pharmacogenomics, 2014

Methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphism is associated with antipsychotic-induced weight gain in first-episode schizophrenia.

Srisawat U et al.

The International Journal of Neuropsychopharmacology, 2014

Pharmacogenetics of antipsychotics.

Brandl EJ et al.

Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie, 2014

31-year-old female shows marked improvement in depression, agitation, and panic attacks after genetic testing was used to inform treatment.

Lawrence S

Case Reports in Psychiatry, 2014

Genetic polymorphisms of serotonin transporter and receptor 1A could influence success during embryo implantation and maintenance of pregnancy.

Palomares AR et al.

Fertility and Sterility, 2013

Genetic variation and the risk of haloperidol-related parkinsonism in elderly patients: a candidate gene approach.

Knol W et al.

Journal of Clinical Psychopharmacology, 2013

Association of the common MC4R rs17782313 polymorphism with antipsychotic-related weight gain.

Czerwensky F et al.

Journal of Clinical Psychopharmacology, 2013

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."