Varaico: Literature-Extracted Genetic Variants

Gene:HTR3B
Variant:p.Y129S
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HTR3B

NM_006028.5:p.Y129S

Associated Papers

Effect of serotonin receptor gene variants on substance use disorders.

Al-Eitan L et al.

Annals of Medicine, 2025

Clinical, ethnic and genetic risk factors associated with postoperative nausea and vomiting in patients undergoing cancer surgery: a case-control study.

Grigio TR et al.

American Journal of Translational Research, 2025

Recurrent somatic mutations of FAT family cadherins induce an aggressive phenotype and poor prognosis in anaplastic large cell lymphoma.

Villa M et al.

British Journal of Cancer, 2024

39478125 (PubMed )
Supplement: 41416_2024_2881_MOESM1_ESM.pdf

Association of HTR3B gene polymorphisms with depression and its executive dysfunction: a case-control study.

Wang L et al.

Bmc Psychiatry, 2023

Role of the Serotonin and GABAA Receptor Gene Polymorphisms in patients with Alcohol Dependence.

Singh R et al.

Asian Journal of Psychiatry, 2023

The serotonin receptor 3E variant is a risk factor for female IBS-D.

Fritz N et al.

Journal of Molecular Medicine (berlin, Germany), 2022

Sensitization of Patient-Derived Colorectal Cancer Organoids to Photon and Proton Radiation by Targeting DNA Damage Response Mechanisms.

Pape K et al.

Cancers, 2022

36291768 (PubMed )
Supplement: cancers-14-04984-s001.zip › Table_S2.xlsx › DD204

Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome: A multicenter retrospective study.

Berens S et al.

World Journal of Gastroenterology, 2022

The Predictive Role of ADRA2A rs1800544 and HTR3B rs3758987 Polymorphisms in Motion Sickness Susceptibility.

Zhang X et al.

International Journal of Environmental Research and Public Health, 2021

Genetic Susceptibility Toward Nausea and Vomiting in Surgical Patients.

Gloor Y et al.

Frontiers in Genetics, 2021

Pharmacogenetics of antiemetics for chemotherapy-induced nausea and vomiting: A systematic review and meta-analysis.

Eliasen A et al.

Critical Reviews in Oncology/hematology, 2020

Pharmacogenetics of Postoperative Nausea and Vomiting.

Aroke EN et al.

Journal of Perianesthesia Nursing : Official Journal of the American Society of Perianesthesia Nurses, 2019

Abnormalities of mucosal serotonin metabolism and 5-HT3 receptor subunit 3C polymorphism in irritable bowel syndrome with diarrhoea predict responsiveness to ondansetron.

Gunn D et al.

Alimentary Pharmacology & Therapeutics, 2019

VMAT2 gene (SLC18A2) variants associated with a greater risk for developing opioid dependence.

Randesi M et al.

Pharmacogenomics, 2019

Association and cis-mQTL analysis of variants in serotonergic genes associated with nicotine dependence in Chinese Han smokers.

Han H et al.

Translational Psychiatry, 2018

Novel human genome variants associated with alcohol use disorders identified in a Lithuanian cohort.

Baronas K et al.

Acta Medica Lituanic, 2018

Renal oncocytoma characterized by the defective complex I of the respiratory chain boosts the synthesis of the ROS scavenger glutathione.

Kürschner G et al.

Oncotarget, 2017

29285300 (PubMed )
Supplement: oncotarget-08-105882-s002.xlsx › nuclear_gene_mutations

The Human Serotonin Type 3 Receptor Gene (HTR3A-E) Allelic Variant Database.

Celli J et al.

Human Mutation, 2017

Common variants of HTR3 genes are associated with obsessive-compulsive disorder and its phenotypic expression.

Kim HW et al.

Scientific Reports, 2016

Single Nucleotide Variant rs2232710 in the Protein Z-Dependent Protease Inhibitor (ZPI, SERPINA10) Gene Is Not Associated with Deep Vein Thrombosis.

Gorski MM et al.

Plos One, 2016

5-HT2A Gene Variants Moderate the Association between PTSD and Reduced Default Mode Network Connectivity.

Miller MW et al.

Frontiers in Neuroscience, 2016

An Analysis of Behavioral and Genetic Risk Factors for Chemotherapy-Induced Nausea and Vomiting in Japanese Subjects.

Mukoyama N et al.

Biological & Pharmaceutical Bulletin, 2016

Association of 5-HT3B Receptor Gene Polymorphisms with the Efficacy of Ondansetron for Postoperative Nausea and Vomiting.

Kim MS et al.

Yonsei Medical Journal, 2015

Susceptibility loci for heroin and cocaine addiction in the serotonergic and adrenergic pathways in populations of different ancestry.

Levran O et al.

Pharmacogenomics, 2015

Genetic influences on response to alcohol and response to pharmacotherapies for alcoholism.

Enoch MA

Pharmacology, Biochemistry, and Behavior, 2014

Association and interaction analyses of 5-HT3 receptor and serotonin transporter genes with alcohol, cocaine, and nicotine dependence using the SAGE data.

Yang J et al.

Human Genetics, 2014

TBX1 mutation identified by exome sequencing in a Japanese family with 22q11.2 deletion syndrome-like craniofacial features and hypocalcemia.

Ogata T et al.

Plos One, 2014

24637876 (PubMed )
Supplement: pone.0091598.s006.pdf

Pharmacogenetic predictors of nausea and vomiting of pregnancy severity and response to antiemetic therapy: a pilot study.

Lehmann AS et al.

Bmc Pregnancy and Childbirth, 2013

Polymorphisms of the serotonin transporter and receptor genes: susceptibility to substance abuse.

Herman AI et al.

Substance Abuse and Rehabilitation, 2012

Replication of functional serotonin receptor type 3A and B variants in bipolar affective disorder: a European multicenter study.

Hammer C et al.

Translational Psychiatry, 2012

Length and amino acid sequence of peptides substituted for the 5-HT3A receptor M3M4 loop may affect channel expression and desensitization.

McKinnon NK et al.

Plos One, 2012

Functional genetic variants that increase synaptic serotonin and 5-HT3 receptor sensitivity predict alcohol and drug dependence.

Enoch MA et al.

Molecular Psychiatry, 2011

Clinical and genetic factors associated with nausea and vomiting in cancer patients receiving opioids.

Laugsand EA et al.

European Journal of Cancer (oxford, England : 1990), 2011

Poor replication of candidate genes for major depressive disorder using genome-wide association data.

Bosker FJ et al.

Molecular Psychiatry, 2011

Are serotonin 3A and 3B receptor genes associated with suicidal behavior in schizophrenia subjects?

Souza RP et al.

Neuroscience Letters, 2011

Pharmacogenetics of antidepressants.

Crisafulli C et al.

Frontiers in Pharmacology, 2011

Triangulation of the human, chimpanzee, and Neanderthal genome sequences identifies potentially compensated mutations.

Zhang G et al.

Human Mutation, 2010

21064102 (PubMed )
Supplement: supplement_1.pdf

A coding variant of the novel serotonin receptor subunit 5-HT3E influences sustained attention in schizophrenia patients.

Lennertz L et al.

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, 2010

Genetic approaches to functional gastrointestinal disorders.

Saito YA et al.

Gastroenterology, 2010

Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia.

Schuhmacher A et al.

Pharmacogenetics and Genomics, 2009

Functional variants of the serotonin receptor type 3A and B gene are associated with eating disorders.

Hammer C et al.

Pharmacogenetics and Genomics, 2009

Pharmacogenetics of selective serotonin reuptake inhibitors and associated adverse drug reactions.

Thomas KL et al.

Pharmacotherapy, 2009

The 5-HT3 receptor--the relationship between structure and function.

Barnes NM et al.

Neuropharmacology, 2009

Characterization of the effects of four HTR3B polymorphisms on human 5-HT3AB receptor expression and signalling.

Krzywkowski K et al.

Pharmacogenetics and Genomics, 2008

Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy.

Fasching PA et al.

Journal of Cancer Research and Clinical Oncology, 2008

Naturally occurring variants in the HTR3B gene significantly alter properties of human heteromeric 5-hydroxytryptamine-3A/B receptors.

Walstab J et al.

Pharmacogenetics and Genomics, 2008

Functional characterization of a -100_-102delAAG deletion-insertion polymorphism in the promoter region of the HTR3B gene.

Meineke C et al.

Pharmacogenetics and Genomics, 2008

High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor.

Krzywkowski K et al.

Proceedings of the National Academy of Sciences of the United States of America, 2008

Genome bioinformatic analysis of nonsynonymous SNPs.

Burke DF et al.

Bmc Bioinformatics, 2007

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."